Called Coronavirus Disease Research Articles

Coronavirus disease 2019 and diabetes mellitus

IntroductionIn late 2019, a new virus severe acute respiratory syndrome coronavirus-2, which causes a new serious disease called coronavirus disease 2019 (COVID-19), spread quickly all over the world. Many complications of diabetes mellitus (DM) such as microvascular and macrovascular complications increase the risk for COVID-19-related severity and mortality.ObjectiveTo assess the effect of DM on outcome and severity of COVID-19.Patients and methodsThis work was a retrospective observation that included confirmed COVID-19-infected patients (PCR positive for COVID-19) who were admitted to Shebin El-Kom Teaching Hospital, Menoufia, Egypt, from March 2021 to March 2022. Laboratory investigations such as age, sex, and sings of severity of COVID-19 were studied. In this study, patients were divided into three main groups as follows: group 1 diabetic patients had known DM, group 2 (hyperglycemic group) patients were without past history of DM but were known to have hyperglycemia with COVID-19, and group 3 (control) had normal blood glucose.ResultsA total of 300 patients were divided into diabetic and hyperglycemic groups and were compared with the control group. It was found that diabetic and hyperglycemic groups were significantly associated with severe and critical disease, long hospital stay, increased number of admissions in critical care unit, increased number of patients under mechanical ventilation, and increased mortality rate from COVID-19 compared with the control group.ConclusionsPatients with DM are more liable for severe acute respiratory syndrome coronavirus-2 infection, ICU admission, and increase in the rate of death. In addition, new hyperglycemia, even without history of DM, increased the severity of COVID-19 infection. Special care should be given for diabetic patients. Therefore, glucose monitoring and tight control of blood glucose are essential for all.

Association of Serum Lactate Dehydrogenase and Qualitative C-Reactive Protein with the Severity of COVID-19 Disease

Introduction: After December 2019, the word “COVID” became the nightmare to the civilisation. As per the nomenclature laid by World Health Organisation (WHO), the disease is called Coronavirus Disease 2019 (COVID-19) and the causative virus is Severe Acute Respiratory Syndrome Corona Virus-2 (SARSCoV-2). By August 11th 2021, the virus caused around 43 lac deaths with an infection burden of approximately 20.3 crore worldwide. Many studies are published from most of the corners of the world regarding clinical features, laboratory parameters and radiological features of the disease to identify the infection at an early stage. Serum Lactate Dehydrogenase (LDH) and C-Reactive Protein (CRP) are among the most commonly studied parameters in COVID-19, though in India, a smaller number of studies were done in this regard. As the disease itself is new to the medical fraternity, maximum studies were done with small sample size which requires more studies to confirm the findings. Aim: To find out the association of on-admission serum LDH and qualitative CRP with the severity of the disease. Materials and Methods: The present study was a retrospective observational study conducted for three months from May to July 2021. A 114 Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) positive COVID-19 patients were included as per the inclusion-exclusion criteria of which 57 were from Intensive Care Unit (ICU), considered as ‘severe’ patients and 57 from ward, taken as ‘non severe’ patients. Required blood parameters including LDH and CRP values were obtained from Laboratory Information System (LIS) and clinical data was obtained from hospital database. The values were analysed using statistical software. Results: Present study showed significant difference in values of LDH among ICU and ward patients (p=0.0001), also significant difference of CRP positive percentage between these two groups (p=0.0003) was observed. Conclusion: Present study concluded that on-admission LDH and CRP can be used as a marker of severity in COVID-19 disease.

SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics

SummarySARS-CoV-2 is a newly identified coronavirus that causes the respiratory disease called coronavirus disease 2019 (COVID-19). With an urgent need for therapeutics, we lack a full understanding of the molecular basis of SARS-CoV-2-induced cellular damage and disease progression. Here, we conducted transcriptomic analysis of human PBMCs, identified significant changes in mitochondrial, ion channel, and protein quality-control gene products. SARS-CoV-2 proteins selectively target cellular organelle compartments, including the endoplasmic reticulum and mitochondria. M-protein, NSP6, ORF3A, ORF9C, and ORF10 bind to mitochondrial PTP complex components cyclophilin D, SPG-7, ANT, ATP synthase, and a previously undescribed CCDC58 (coiled-coil domain containing protein 58). Knockdown of CCDC58 or mPTP blocker cyclosporin A pretreatment enhances mitochondrial Ca2+ retention capacity and bioenergetics. SARS-CoV-2 infection exacerbates cardiomyocyte autophagy and promotes cell death that was suppressed by cyclosporin A treatment. Our findings reveal that SARS-CoV-2 viral proteins suppress cardiomyocyte mitochondrial function that disrupts cardiomyocyte Ca2+ cycling and cell viability.

Söke Bölgesi'nde COVID-19 Pandemi Sürecinde Diş Hekimine Başvuran Bir Grup Türk Hastada Durumluk-Sürekli Anksiyete Seviyelerinin, Dental Anksiyete Seviyelerinin ve Aşıya Karşı Tutumlarının Belirlenmesi: Analitik Araştırma

Objective: A new disease called coronavirus disease2019 (COVID‐19), was discovered in the city of Wuhan in China and has quickly reached many countries. During this period, mental health of people was affected negatively. This study aimed to evaluate the anxiety levels of dental patients during the COVID-19 pandemic, determine the reasons for admission to the dental center, and to investigate the rate of COVID-19 vaccine hesitancy. Material and Methods: A questionnaire consisting of the stated topics and demographic data was completed by the patients. State-Trait Anxiety Inventory (STAI) scales were used to determine anxiety levels and the Corah-Dental Anxiety Scale (DAS) was also used to assess dental anxiety. Results: The DAS scores showed that patients had low levels of dental anxiety, while STAI-State and STAI-Trait scores showed that most patients were moderately anxious. Gender, age, marital status, education, and location of residence were associated with higher DAS and/or STAI scores. Vaccine hesitancy was reported in 28.31% of patients. Side effects and the unknown long-term effects of the COVID-19 vaccine were given as major reasons for vaccine hesitancy (34.13%). Conclusion: Our results reveal that there was a concerning level of anxiety and vaccine hesitancy in a group of Turkish dental patients during COVID-19 pandemic in Soke Region.

SURVEY PERILAKU PENANGGULANGAN UPAYA PENCEGAHAN COVID-19 PADA TATANAN KELUARGA PADA MAHASISWA KEPERAWATAN DAN KEBIDANAN

Corona virus (SARS-cov-2), is a disease called Coronavirus disease 2019 (Covid-19). The behavior of the community towards the prevention of Covid-19 is still low, which is thought to play a role in the increase in cases from time to time. The role of the community is urgently needed to suppress the transmission of Covid-19. The general public, in this case the D-three students of Midwifery and Nursing at the Medan Ministry of Health Poltekkes, need to disseminate information on the transmission of Covid-19. Surveys on student behavior can play a role in socializing the prevention of Covid-19 transmission. This study aims to determine the description of student behavior towards the prevention of Covid-19 transmission in the family setting. The research method with a survey, identifies the characteristics of the D-three Nursing and Midwifery students and their behavior (knowledge, attitudes and actions) towards the prevention of Covid-19 in the family setting. Data collection from March to May 2020. The population is D-three students in Midwifery and Nursing with a total of 595 respondents. The research procedure was carried out by collecting data through google forms such as student characteristics (gender, age, ethnicity, place of residence, level/class), behavior (knowledge, attitudes and actions) regarding overcoming Covid-19 prevention efforts in the family setting. The results of the study: 97.6% of the information regarding the prevention of Covid-19 transmission, the general source of information was through social media, 85.8%, 68.1% of respondents with good knowledge, 79.4% strongly agree, do prevention 68.9%, and in the family setting the attitude of the family strongly agrees 69.6%. There needs to be further learning for students about infectious disease pandemics in the community, especially the prevention of Covid-19 transmission in the family and community settings.

COVID-19 in Children: Update on Diagnosis and Management.

In December 2019, a new infectious disease called coronavirus disease 2019 (COVID-19) attributed to the new virus named severe scute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected. The gold standard for the diagnosis of SARS-CoV-2 infection is the viral identification in nasopharyngeal swab by real-time polymerase chain reaction. Few data on the role of imaging are available in the pediatric population. Similarly, considering that symptomatic therapy is adequate in most of the pediatric patients with COVID-19, few pediatric pharmacological studies are available. The main aim of this review is to describe and discuss the scientific literature on various imaging approaches and therapeutic management in children and adolescents affected by COVID-19. Clinical manifestations of COVID-19 are less severe in children than in adults and as a consequence the radiologic findings are less marked. If imaging is needed, chest radiography is the first imaging modality of choice in the presence of moderate-to-severe symptoms. Regarding therapy, acetaminophen or ibuprofen are appropriate for the vast majority of pediatric patients. Other drugs should be prescribed following an appropriate individualized approach. Due to the characteristics of COVID-19 in pediatric age, the importance of strengthening the network between hospital and territorial pediatrics for an appropriate diagnosis and therapeutic management represents a priority.

Clinical challenges of stress cardiomyopathy during coronavirus 2019 epidemic

A type of viral pneumonia that broke out in Wuhan, China in December 2019, and new strains of it are spreading rapidly around the world, is called coronavirus disease 2019 (COVID-19). The incidence of cardiovascular complications has increased both in the general population and in patients diagnosed with the disease during the COVID-19 epidemic. One of the conditions is stress cardiomyopathy, which may be related to COVID-19. During the COVID-19 epidemic, stress cardiomyopathy may be present as a complication of acute infection or as an indirect consequence of quarantine. These conditions have created complications in patient care that have led to increased adverse outcomes, hospitalization, and medical costs. Stress cardiomyopathy is caused by various emotional and physical stressors such as anger, sadness, happiness, surgery, multiple medications, general anesthesia, and infectious diseases. The outbreak of the new coronavirus has posed an ongoing challenge for these patients with several medical and economic consequences. Providing useful information on stress and COVID-19 to people with heart disease and their families can be very important, and also, education and psychotherapy of heart patients can reduce the number of hospitalization and their complications.

HUBUNGAN KARAKTERISTIK MASYARAKAT DENGAN KEJADIAN COVID 19 DI DESA PAYUNG KECAMATAN WELERI

At this time there is a health problem that is in the spotlight and attention of the world, namely the Covid-19 disease. This disease is caused by a virus called Corona Virus Disease – 19 or more popularly known as Covid-19. In response to this, the government has issued a policy or regulation to prevent the increase in the number of cases, namely in the form of a health protocol for handling Covid-19. The government has issued health protocols for handling Covid-19, including health protocols, borders, communications, education areas, and public and transportation areas, including policies in the form of implementing Large-Scale Social Restrictions (PSBB) in several areas in Indonesia. This study aims to determine the relationship between community characteristics and the incidence of covid 19 in Payung Village, Weleri District. Research design is descriptive correlation with sampling technique using simple random sampling with a sample of 58 respondents. Statistical analysis using chi square. From the results of the study, it was found that there was a relationship between age, gender, education and occupation with the incidence of Covid-19 in Payung Village, Weleri District with a p value <0.05.

Hair, Nail, and Skin Changes during COVID 19 Era

Background: In December 2019, unexplained cases of viral pneumonia caused by a new coronavirus pathogen (SARS-CoV-2) began to be reported in China, and the disease was called Coronavirus Disease 2019 (COVID-19). Guidelines issued by WHO and other agencies have been consistent about the need for physical distancing, respiratory protection with a face mask, hand wash, and the use of disinfectant to clean frequently touched surfaces daily. Aim to identify the possible effect of the protective measures against COVID19 virus on the hair nail, and skin. Methodology This study was conducted as a prospective cross sectional study using an online questionnaire. The participants were from different Iraqi cities. The study was carried out from the first of June to the end of August, 2020, Results: There were 1893 cases that reported different skin complains, 55% complained of hand dermatitis, and about 64% of cases showed mask marks and rashs. And more than 64% patients complained of notable hair loss. A 56% of participants reported nails brittle and dullness. Conclusion: For balancing the benefits and the harm it is essential to support strategies to protect the skin (using products devoid of common allergens, using products with added moisturizers, and applying moisturizers immediately after hand washing or before gloves use and healthy diet).

Prophylaxis and treatment of pulmonary thromboembolism in COVID-19 patients

In 2019, a completely unique pneumonia, called coronavirus disease 2019 (COVID-19), spread rapidly throughout the planet. This novel global pandemic severely threatened public respiratory health and medical services. To date, apart from the common respiratory symptoms, coagulation disorders, especially Pulmonary Thromboembolism (PTE), has been proven as a crucial complication in severe COVID-19 patients, and therefore the incidence of PTE causes poor clinical outcome and increased fatality. Therefore, it’s important that healthcare providers, including respiratory physicians, medicine specialists, hematologists, cardiologists, communicable disease specialists, and other specialists, recognize that patients with COVID-19 are at increased risk of PTE, and make sure that appropriate prophylaxis is run to the acceptable patients, which they effectively manage PTE when it does occur. The mechanism of PTE in patients with coronavirus pneumonia consists of endothelial injury, activated platelet, cytokine storm, and a suppressed fibrinolytic system. Early prophylaxis, antiviral therapy, anticoagulation, and supportive treatment are beneficial to COVID-19 patients. In this review, we summarize the harm that coronavirus pneumonia wreaks and highlight the clinical relationship between PTE and coronavirus infection. The potential mechanism and therefore the prophylaxis and therapeutic measures also are discussed to involve more effort and research to research the strategies for PTE in COVID-19.

Coronavirus infection in patients with diabetes.

Diabetes mellitus is a complex, multifactorial, chronic disease characterized by impaired metabolism of glucose, fats and proteins. Patients who suffer from it frequently have hyperglycemia and coronary artery disease is the leading cause of death. The comorbidities associated with diabetes are overweight and obesity, systemic arterial hypertension, atherogenic dyslipidemia and in some patients peripheral vascular disease, kidney damage, neuropathy and retinopathy. Chronic lack of control of the disease is associated with increased susceptibility to infections, which generally have few symptoms, but hyperglycemia is generally magnified, which worsens the course of infections. Since December 2019, when the disease caused by one of the coronaviruses (coronavirus 2 of severe acute respiratory syndrome, SARS-CoV-2) was identified and has been called coronavirus disease 2019 (COVID-19), there have been some reports that associate the presence of diabetes with an increased risk of mortality. In this review article we have focused on four specific points: 1) epidemiology of the prevalence and mortality of COVID 19 in the general population and in the population with type 2 diabetes mellitus; 2) pathophysiology related to the binding of SARS-CoV-2 to receptors in subjects with diabetes; 3) the immune response induced by SARS-CoV-2, and 4) the outpatient and hospital treatment recommended in patients with diabetes who become infected with SARS-CoV-2.

Tanggung Jawab Pemerintah Memberikan Pelayanan Kesehatan Terhadap Masyarakat Dalam Mengatasi Pandemic Covid-19 Berdasarkan Undang-undang Nomor 36 Tahun 2009 Tentang Kesehatan

Health is one of the basic human needs besides clothing, food and shelter. Healthy humans will be able to carry out all activities that are useful for their lives and vice versa sick humans cannot carry out daily activities properly. To realize a healthy human being is not only a personal responsibility but more broadly the responsibility of the state to its citizens. The government as the holder of executive power in charge of administering the government to achieve the country's goals must quickly respond to what is happening and developing in the community. In 2020 the world was hit by an outbreak of a disease caused by a virus called Corona Virus Disease which was later known as COVID-19. To provide health protection to the public, the government has issued a statutory regulation, namely Law Number 36 of 2009 concerning Health. In this law has been regulated about the government's responsibility in providing health protection as stated in Article 14 to Article 20 of Law No. 36 of 2009 concerning Health. Management of Government Responsibilities in Providing Health Services to the Community in Overcoming the COVID-19 Pandemic Based on Law No. 36 of 2009 concerning Health includes planning, organizing, mobilizing and supervising

An Effective SARS-CoV-2 Electrochemical Biosensor with Modifiable Dual Probes Using a Modified Screen-Printed Carbon Electrode.

Due to the severe acute respiratory syndrome coronavirus (SARS-CoV-2, also called coronavirus disease 2019 (COVID-19)) pandemic starting in early 2020, all social activities ceased in order to combat its high transmission rate. Since vaccination combats one aspect for halting the spread of the virus, the biosensor community has looked at another aspect of reducing the burden of the COVID-19 pandemic on society by developing biosensors that incorporate point-of-care (POC) testing and the rapid identification of those affected in order to deploy appropriate measures. In this study, we aim first to propose a screen-printed carbon electrode (SPCE)-based electrochemical biosensor that meets the ASSURED criteria (i.e., affordable, sensitive, specific, user-friendly, rapid, equipment-free, and deliverable) for POC testing, but more importantly, we describe the novelty of our biosensor’s modifiability that uses custom dual probes made from target nucleic acid sequences. Additionally, regarding the sensitivity of the biosensor, the lowest sample concentration was 10 pM (p = 0.0257) without amplification, which might challenge the traditional technique of reverse transcriptase-polymerase chain reaction (RT-PCR). The purpose of this study is to develop a means of diagnostics for the current pandemic as well as to provide an established POC platform for future epidemics.

Evidence for facial nerve palsy and SARS-CoV-2

Introduction. The World Health Organization (WHO) has recognized a new strain of coronavirus, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), called Coronavirus Disease 2019 (COVID-19). The mildest and most common symptoms include fever, fatigue and cough; however, more severe cases of the disease can cause breathing difficulties, kidney and heart failure and, eventually, death. However, an increasing number of reports of neurological manifestations have emerged. Objective. Provide a comprehensive review of the neurological manifestations of SARS-CoV-2 and especially the relationship between acute facial nerve palsy and COVID-19, as well as their results in mortality and the implications that this has in clinical practice. Method. The search in seven databases (PubMed, Cochrane Library, Lilacs, Scielo, Web of Science, Scopus and Google Scholar) was carried out by two independent reviewers in search of evidence of Facial Nerve Palsy (VII) and SARS-CoV-2 . After screening, data were collected and discussed. Results. Idiopathic facial palsy is called Bell's palsy and studies have shown that facial palsy increased during the COVID-19 pandemic period. There are many reports on the relationship between COVID-19 and facial paralysis, but little real evidence of their relationship. Conclusion. It is still questionable whether these neuroimmune disorders occur directly from viral infection or as autoimmune sequelae. The pathogenesis of the disease behind this manifestation is not yet fully understood. We believe that more research should be carried out to clarify the association raised by this study.

Evaluation of Hyponatremia and Predictors of Hyponatremia in Patients Hospitalized with the COVID-19

Aim: The infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), called coronavirus disease-2019 (COVID-19), has been declared by the World Health Organization as a pandemic. Moderate and severe hyponatremia may develop in COVID-19 cases. This study aimed to evaluate the frequency and predictors of hyponatremia in patients hospitalized with COVID-19. Materials and Methods: This retrospective study included patients aged >18 years who were admitted to our hospital between August 1st, 2020, and September 30th, 2020, with positive RNA polymerase chain reaction (PCR) test. Patients' demographic data, comorbidities, vital signs, physical examination findings, laboratory results, sodium levels, and hospital outcomes were evaluated. Results: The study included 760 patients with positive PCR test results. Of all the patients, 47.6% were female, and the median age was 63 years. The in-hospital mortality rate was 11.7%. The median sodium level was 137 (134-140). Hyponatremia was present in 25.7% of the patients, and majority of the patients had mild hyponatremia. Hyponatremia was observed more frequently in patients with advanced age, male gender, diabetes, and severe pneumonia (p=0.041, p=0.003, p<0.001, p=0.002, respectively). Conclusion: In this study, hyponatremia is relatively common in patients admitted with COVID-19 pneumonia, and it is associated with higher disease severity. The incidence of hyponatremia increases in older patients, male patients, patients with severe pneumonia, and patients with diabetes.

Enisamium Inhibits SARS-CoV-2 RNA Synthesis.

Pandemic SARS-CoV-2 causes a mild to severe respiratory disease called coronavirus disease 2019 (COVID-19). While control of the SARS-CoV-2 spread partly depends on vaccine-induced or naturally acquired protective herd immunity, antiviral strategies are still needed to manage COVID-19. Enisamium is an inhibitor of influenza A and B viruses in cell culture and clinically approved in countries of the Commonwealth of Independent States. In vitro, enisamium acts through metabolite VR17-04 and inhibits the activity of the influenza A virus RNA polymerase. Here we show that enisamium can inhibit coronavirus infections in NHBE and Caco-2 cells, and the activity of the SARS-CoV-2 RNA polymerase in vitro. Docking and molecular dynamics simulations provide insight into the mechanism of action and indicate that enisamium metabolite VR17-04 prevents GTP and UTP incorporation. Overall, these results suggest that enisamium is an inhibitor of SARS-CoV-2 RNA synthesis in vitro.

Epigenetic Mechanisms Underlying COVID-19 Pathogenesis.

In 2019, a novel severe acute respiratory syndrome called coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was reported and was declared a pandemic by the World Health Organization (WHO) in March 2020. With the advancing development of COVID-19 vaccines and their administration globally, it is expected that COVID-19 will converge in the future; however, the situation remains unpredictable because of a series of reports regarding SARS-CoV-2 variants. Currently, there are still few specific effective treatments for COVID-19, as many unanswered questions remain regarding the pathogenic mechanism of COVID-19. Continued elucidation of COVID-19 pathogenic mechanisms is a matter of global importance. In this regard, recent reports have suggested that epigenetics plays an important role; for instance, the expression of angiotensin I converting enzyme 2 (ACE2) receptor, an important factor in human infection with SARS-CoV-2, is epigenetically regulated; further, DNA methylation status is reported to be unique to patients with COVID-19. In this review, we focus on epigenetic mechanisms to provide a new molecular framework for elucidating the pathogenesis of SARS-CoV-2 infection in humans and of COVID-19, along with the possibility of new diagnostic and therapeutic strategies.

MENINGKATKAN KESADARAN MASYARAKAT UNTUK MEMATUHI PROTOKOL KESEHATAN DI ERA PPKM DENGAN MEDIA POSTER MELALUI WAGRAM (WHATSAPP, INSTAGRAM DAN YOUTUBE)

The world is surprised by the presence of new virus called Corona virus new type (SARS-CoV-2) whic its illness is called Corona virus Disease (Covid-19) in the beginning of 2020. To prevent the spread of Covid-19, the government has conducted various prevention efforts. Starting from the prevailing of area quarantine, PSBB (Big Scale of Social Restriction), PPKM (Implementation of Rectrictions on Community Activities), and so on. As a form of community service, the authors in community service activity (KKN) conducted one of work program related to PPKM. The writing of this paper focuses on the effort to increase the community awareness to obey health protocol in PPKM era with poster media through whatsapp group, instagram, and youtube. The method used was descriptive method. The issuance of this PPKM policy aims to control the community activity which has potential to enlarge the transmission of Covid-19. It it is not done, sooner or later it will impact on various sectors either social, culture, or economic growth will experience difficulty, industry will not run as it should be, or the community will lost their livelihood. As a result, by the presence of this socialization by using poster media through whatsapp group and instagram the community can stay productive by considering health protocol during Covid-19 pandemic. Therefore, the community must start to adapt with new life habit during PPKM

COVID-19 in Continental America

Background: In late December 2019, a coronavirus outbreak first occurred in Wuhan, China, and then spread worldwide, which became a major global emergency. This severe respiratory illness called coronavirus disease 2019 (COVID-19) is transmitted through respiratory droplets and contaminated surfaces. Objectives: This study aimed to investigate the epidemiology of COVID-19 in continental America. Methods: This study was an ecological study describing the epidemiological features of COVID-19 in the Americas. The data of identified definitive cases and deaths from this disease and other information were extracted from the reports of the World Health Organization and transferred to SPSS software (version 24). Furthermore, the case fatality rate was separately calculated for each country. Results: The highest number of COVID-19 reported cases and the highest COVID-19 mortality rate were in the United States, with 72,186,963 and 1,896,955 cases, respectively. Moreover, the highest case fatality rate was reported as 9.38% in Peru. Conclusions: The prevention of COVID-19 transmission in countries is possible with general vaccination and observation of social distancing. These measures reduce the transmission of COVID-19 and are effective ways to control this global health problem.

Statistic Assessment of Spreading Cases (Total Confirmed, Recovered, Death) From Different AreasContain Novel Coronavirus (2019-n Cov)

Background: In Wuhan, Hubei Province, China 31, December 2019 were discovered several cases ofpneumonia of unknown causation and correlated to Wholesale Market Huanan Seafood.And caused acuteviral respiratory diseases called Coronavirus Disease 2019 (COVID-19).Aim: The aim of this study is statistic assessment of cases (total confirmed, recovered, death) from differentareas in world, Arab nation and in Iraq contain 2019-n CoV.Methods:The first study include collected data from Center for System Science and Engineering (CSSE)at John’s Hopkins University and Iraqi Ministry of Health website daily reports from 29 st February to 31thDecember 2020 of people infected with 2019- nCoV.Results: From this statistics the prevalence of 2019-nCoV the spreadingcases (83.561.252 totalconfirmed,47.136.188 global recovered and 1.820.668 global death) from 191 countries in the world.The most distribution confirmed cases represent in (19.975.250 US, 10.286.709 India, 7.675.973 Brazil,3.153.960 Russia, 2.677.806 France, 2.496.231 United Kingdom, 2.208.652 Turkey, 2.107.166 Italy). Alsoglobal recovered represent in (9.883.461 India, 6.848.844 Brazil, 2.553.467 Russia, 2.100.650 Turkey,1.508.419Colombia, 1.463.111 Italy, 1.426.676 Argentina, 1.355.384 Germany). And global death representin (345.844 US, 194.949 Brazil, 148.994 India, 125.807 Mexico,74.159 Italy, 73.622 United Kingdom,64.760 France, 56.798 Russia).From this result the Arab nation including 3.139.205 total confirmed cases,2.783.448 recovered cases and 55.326 death cases from 21 countries infected with 2019-n CoVbetweenthis result the Iraqi infected patients represent 595.291 total confirmed cases, 537.841 recovered cases and12.813 death cases.Conclusions: In concluded, the percentage of 2010-n CoV increase in all the global confirmed cases indifferent areas of the world and become pandemic.In Iraq show the infection is mild to moderate in spite ofno special antiviral and vaccine is present.