Beam Calibration Research Articles

Clinical radiotherapy application of N-vinylpyrrolidone-containing 3D polymer gel dosimeters with remote external MR-reading

PurposeAdvanced 3D dosimetry is required for verifications of complex dose distributions in modern radiotherapy. Two 3D polymer gel dosimeters, coupled with magnetic resonance (MR) imaging (3 T MRI) readout and data processing with polyGeVero® software, were tested for the verification of calculated 3D dose distributions by a treatment planning system (TPS) and ArcCHECK®–3DVH®, related to eradication of a lung tumour. MethodsN-vinylpyrrolidone-containing 3D polymer gel dosimeters were used: VIC (containing ascorbic acid and copper sulfate pentahydrate) and VIC-T (containing tetrakis(hydroxymethyl)phosphonium chloride). Three remote centers were involved in the dosimeters preparation and irradiation (Poland), and MRI (Austria). Cross beam calibration of the dosimeters and verification of a 3D dose distribution calculated with an Eclipse External Beam TPS and ArcCHECK®–3DVH® were performed. The 3D-to-3D comparisons of the VIC and VIC-T with TPS and ArcCHECK®–3DVH® along with ArcCHECK®–3DVH® versus TPS dose matrixes were performed with the aid of the polyGeVero® by analyzing dose profiles, isodoses lines, gamma index, gamma angle, dose difference, and related histograms. ResultsThe measured MR-relaxation rate (R2 = 1/T2) for the dosimeters relates to the dose, as follows: R2 = 0.0928 ± 0.0008 [Gy−1 s−1] × D [Gy] + 2.985 ± 0.012 [s−1] (VIC) and 0.1839 ± 0.0044 [Gy−1 s−1] × D [Gy] + 2.519 ± 0.053 [s−1] (VIC-T). The 3D-to-3D comparisons revealed a good agreement between the measured and calculated 3D dose distributions. ConclusionsVIC and VIC-T with 3T MRI readout and polyGeVero® showed potential for verifications of calculated irradiation plans. The results obtained suggest the implementation of the irradiation plan for eradication of the lung tumour.

On the use of the absorbed depth-dose measurements in the beam calibration of a surface electronic high-dose-rate brachytherapy unit, a Monte Carlo-based study.

To evaluate the use of the absorbed depth-dose as a surrogate of the half-value layer in the calibration of a high-dose-rate electronic brachytherapy (eBT) equipment. The effect of the manufacturing tolerances and the absorbed depth-dose measurement uncertainties in the calibration process are also addressed. The eBT system Esteya® (Elekta Brachytherapy, Veenendaal, The Netherlands) has been chosen as a proof-of-concept to illustrate the feasibility of the proposed method, using its 10mm diameter applicator. Two calibration protocols recommended by the AAPM (TG-61) and the IAEA (TRS-398) for low-energy photon beams were evaluated. The required Monte Carlo (MC) simulations were carried out using PENELOPE2014. Several MC simulations were performed modifying the flattening filter thickness and the x-ray tube potential, generating one absorbed depth-dose curve and a complete set of parameters required in the beam calibration (i.e., HVL, backscatter factor (Bw ), and mass energy-absorption coefficient ratios (µen /ρ)water,air ), for each configuration. Fits between each parameter and some absorbed dose-ratios calculated from the absorbed depth-dose curves were established. The effect of the manufacturing tolerances and the absorbed dose-ratio uncertainties over the calibration process were evaluated by propagating their values over the fitting function, comparing the overall calibration uncertainties against reference values. We proposed four scenarios of uncertainty (from 0% to 10%) in the dose-ratio determination to evaluate its effect in the calibration process. The manufacturing tolerance of the flattening filter (±0.035mm) produces a change of 1.4% in the calculated HVL and a negligible effect over the Bw , (µen /ρ)water,air , and the overall calibration uncertainty. A potential variation of 14% of the electron energies due to manufacturing tolerances in the x-ray tube (69.5±~10keV) generates a variation of 10% in the HVL. However, this change has a negligible effect over the Bw and (µen /ρ)water,air , adding 0.1% to the overall calibration uncertainty. The fitting functions reproduce the data with an uncertainty (k=2) below 1%, 0.5%, and 0.4% for the HVL, Bw , and (µen /ρ)water,air , respectively. The four studied absorbed dose-ratio uncertainty scenarios add, in the worst-case scenario, 0.2% to the overall uncertainty of the calibration process. This work shows the feasibility of using the absorbed depth-dose curve in the calibration of an eBT system with minimal loss of precision.

Assessing Dual-Polarization Radar Estimates of Extreme Rainfall during Hurricane Harvey

AbstractHurricane Harvey hit the Texas Gulf Coast as a major hurricane on 25 August 2017 before exiting the state as a tropical storm on 29 August 2017. Left in its wake was historic flooding, with some locations measuring more than 60 in. (150 cm) of rain over a 5-day period. The WSR-88D radar (KHGX) maintained operations for the entirety of the event. Rain gauge data from the Harris County Flood Warning System (HCFWS) was used for validation with the full radar dataset to retrieve daily and event-total precipitation estimates for the period 25–29 August 2017. The KHGX precipitation estimates were then compared with the HCFWS gauges. Three different hybrid polarimetric rainfall retrievals were used, along with attenuation-based retrieval that employs the radar-observed differential propagation. An advantage of using a attenuation-based retrieval is its immunity to partial beam blockage and calibration errors in reflectivity and differential reflectivity. All of the retrievals are susceptible to changes in the observed drop size distribution (DSD). No in situ DSD data were available over the study area, so changes in the DSD were interpreted by examining the observed radar data. We examined the parameter space of two key values in the attenuation retrieval to test the sensitivity of the rain retrieval. Selecting a value of α = 0.015 and β = 0.600 provided the best overall results, relative to the gauges, but more work needs to be done to develop an automated technique to account for changes in the ambient DSD.

Dynamic calibration method of the laser beam for a non-orthogonal shaft laser theodolite measurement system.

The non-orthogonal shaft laser theodolite (N-theodolite) measurement system is a new kind of instrument applied to large-scale metrology. The system consists of two identical N-theodolites, each of which is made up of a two-dimensional rotary table and one collimated laser. The three axes of the N-theodolite have no strict requirements on their orthogonality and intersection conditions. A novel method, to the best of our knowledge, is proposed to calibrate the N-theodolite measurement system, and the calibration method of the laser beam for N-theodolite is the key innovation aspect of this paper. The laser beam is calibrated through dynamic rotation. Throughout the experiment, the straightness accuracy of the laser beam of the left N-theodolite is 0.08 mm and the right N-theodolite is 0.074 mm. The repeatability of the straightness accuracy is ${\pm 0.032}\,\,{\rm mm}$±0.032mm. The uncertainty of straightness accuracy is 0.040 mm. The measurement experiment results show that the maximum deviation of the measured value of this system is 0.34 mm at a range of 5 m, which is verified to be a feasible method for the calibration of the laser beam.

Technical Note: Comprehensive evaluation and implementation of two independent methods for beam monitor calibration for proton scanning beam.

To clinically implement and comprehensively evaluate two independent methods for beam monitor calibration of scanning proton beam. Seven proton energies that represent the lowest to highest energy proton beams were selected. Single energy layer circular fields of diameter 15cm with 2.5mm spot spacing and 10 times of repainting (FS15cm ) were designed for all energies. The effective measurement points of Bragg peak chamber (BPC), advanced Markus chamber (AMC) and farmer chamber (FC) were all aligned to 2cm depth in water using SSD setup. The BPC and AMC were cross-calibrated with farmer chamber (FC) using the field FS15cm . In order to evaluate BPC's lateral response uniformity, a collimated narrow proton beam (5.8mm diameter) was delivered to the active area and edge of the BPC. The dose area product (DAP) was measured using two methods by two BPCs, one AMC and one FC. For method 1, a single spot proton beam was delivered to the geometric center of the BPC. For method 2, the fields FS15cm were delivered to FC and AMC, respectively. Accumulated charges by these chambers were converted to DAPs, and the quantitative difference of DAPs between both methods was calculated. The causes of the uncertainties were discussed, and the advantages of the two methods were compared. The two BPCs showed different lateral response uniformity. BPC1 has a uniform response from the center up to a radius of 3.5cm. BPC2 has a uniform response only to 2cm and the response dropped 1% to 2% at 3.5cm from center. BPC2 also has significant over-response compared to BPC1. A 2.2% systematic error would be transferred to DAP if the over-response from BPC2 was not considered. The DAPs measured by method 1 with two BPCs and by method 2 with FC and AMC were consistent to 0.5%. The major uncertainty component of method 1 is from the cross-calibration of the BPC. The two independent methods for DAP were shown to give consistent results, given the sources of uncertainties were carefully addressed in the measurements. Direct measurement of DAP with BPC is very efficient, but it may be subject to more than 2% systematic error if the BPC lateral response is not carefully evaluated.

Mesoscopic quantitative chemical analyses using STEM-EDX in current and next generation polycrystalline Ni-based superalloys

Quantitative chemical analyses of Ni3Al based hardening precipitates (γ′) in polycrystalline Ni based superalloys have been conducted using energy dispersive X-ray spectroscopy (EDX), coupled with a scanning transmission electron microscope (STEM). The aim of the current investigation is (1) to evaluate the accuracy of calibration (k factor determinations and absorption corrections using a combination of differential X-ray absorption (DXA) and convergent beam electron diffraction (CBED)) by comparing with thermodynamic calculations and (2) to demonstrate the importance of the EDX chemical analysis by taking advantage of its unique capabilities to analyse sub-micron scale chemistries within a mesoscopic field of view under STEM. Our experimental findings show good agreement with the mole fraction ratio of γ′ to the disordered γ matrix predicted using the Lever rule on a thermodynamically stabilised unimodal superalloy, RR1000. The significance of analysing a statistically viable number of samples in thermodynamically metastable superalloys and the chemical fluctuations found in coarse γ′, sized above 200 nm on a scale of a few hundred nanometres in the context of solving a complex morphological evolution of γ′ particles is demonstrated.

A Quasi-Monochromatic Calibration Beam of Secondary Electrons at the Pakhra Accelerator

The characteristics of the quasi-monochromatic calibration beam of secondary electrons at the Pakhra accelerator (Lebedev Physical Institute) on the basis of the SP-57 magnet are presented. The energy resolution of the beam with a copper converter 0.1–5.0 mm thick and an interpolar magnet gap of 6 cm is δ = 10.0–4.5% in accordance with the energy in the electron-beam energy range E = 98–294 MeV.

A Novel Calibration Method of Articulated Laser Sensor for Trans-Scale 3D Measurement.

The articulated laser sensor is a new kind of trans-scale and non-contact measurement instrument in regular-size space and industrial applications. These sensors overcome many deficiencies and application limitations of traditional measurement methods. The articulated laser sensor consists of two articulated laser sensing modules, and each module is made up of two rotary tables and one collimated laser. The three axes represent a non-orthogonal shaft architecture. The calibration method of system parameters for traditional instruments is no longer suitable. A novel high-accuracy calibration method of an articulated laser sensor for trans-scale 3D measurement is proposed. Based on perspective projection models and image processing techniques, the calibration method of the laser beam is the key innovative aspect of this study and is introduced in detail. The experimental results show that a maximum distance error of 0.05 mm was detected with the articulated laser sensor. We demonstrate that the proposed high-accuracy calibration method is feasible and effective, particularly for the calibration of laser beams.

Scanned Proton Beam Performance and Calibration of the Shanghai Advanced Proton Therapy Facility

The Shanghai Advanced Proton Therapy facility (SAPT) is a hospital-based facility that began construction in December of 2014 with commissioning of the first scanned proton beam line starting in October of 2017. Proton beams are extracted from a synchrotron accelerator with energies between 70 and 235 MeV. Beam delivery uses the modulated scanning and energy stacking techniques to produce a maximal scanning area of 40 × 30 cm2 at the iso-center. Prior to clinical use, the beam delivery system was characterized and calibrated following the guidelines of the IEC 62667 medical electronic equipment standard including the spot size in air, spot position, depth dose distributions, and lateral dose profiles, as well as the beam monitor calibrations following the IAEA TRS-398 recommendations with small differences.•The measured dosimetric results showed that the full width at half maximum (FWHM) for the beam spot size in air varied approximately from 6 mm to 13 mm. The dose fall-off (DDF) derived from the measured depth dose in water varied from 4.7 mm at 235 MeV to 0.7 mm at 70 MeV. The homogeneity of the scanned field was better than 2% for various energies as expected.•Furthermore, the beam reproducibility and proportionality delivery accuracy was also stable with the results better than 0.1% and 1% respectively. Finally, the dose monitor calibration factor, its reproducibility and stability were tested. Reproducibility tests exhibited a standard deviation (SD) result of less than 1% during the test period.•All the measured dosimetric parameters showed that the design specifications were well achieved and the results are suitable for being used as a part of the clinical commissioning and quality assurance program for treating patients.

Validation and IMRT/VMAT delivery quality of a preconfigured fast-rotating O-ring linac system.

A fast-rotating O-ring dedicated intensity modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) delivery system, the Halcyon, is delivered by default with a fully preconfigured photon beam model in the treatment planning system (TPS). This work reports on the validation and achieved IMRT/VMAT delivery quality on the system. Acceptance testing followed the vendor's installation product acceptance and was supplemented with mechanical QA. The dosimetric calibration was performed according to the IAEA TRS-398 code-of-practice, delivering 600 cGy/min at 10 cm depth, a 90 cm source-surface distance, and a 10 × 10 cm² field size. The output factors, multileaf collimator (MLC) transmission and dosimetric leaf gap (DLG) were validated by comparing measurements with the modeled values in the TPS. Validation of IMRT/VMAT was conducted following AAPM reports (MPPG 5.a, TG-119). Next, dose measurements were performed for end-to-end (E2E) checks in heterogeneous anthropomorphic phantoms using radiochromic film in multiple planes and using ionization chambers (IC) point measurements. E2E checks were performed for VMAT (cranial, rectum, spine, and head and neck) and IMRT (lung). Additionally, IROC Houston mailed dosimetry audits were performed for the beam calibration and E2E measurements using a thorax phantom (IMRT) and a head and neck phantom (VMAT). Lastly, extensive patient-specific QA was performed for the first patients of each new indication, 26 in total (nrectum = 2, nspine = 5, nlung = 5, nesophagus = 2, nhead and neck = 7, ncranial = 5), treated on the fast-rotating O-ring linac. The patient-specific QA followed the AAPM TG-218 guidelines and comprised of portal dosimetry, ArcCHECK diode array, radiochromic film dosimetry in a MultiCube phantom, and IC point measurements. The measured output factors showed an agreement <1% for fields ≥3 × 3 cm². Field sizes ≤2 × 2 cm² had a difference of <2%. The measured single-layer MLC transmission was 0.42 ± 0.01% and the measured DLG was 0.27 ± 0.22 mm. The AAPM MPPG 5.a measurements were fully compliant with the guideline criteria. Dose differences larger than 2% were found for the PDD at large depths (>25 cm). TG-119's confidence limits were achieved for the VMAT point dose measurements and for both the IMRT and VMAT radiochromic film measurements. The TG-119 confidence limits were not achieved for IMRT point dose measurements in both the target (5.9%) and the avoidance structure (6.4%). All E2E tests had point differences below 2.3% and gamma agreement scores above 90.6%. The IROC beam calibration audit showed agreement of <1%. The IROC lung IMRT audit and head and neck VMAT audit had results compliant with the IROC Houston's credentialing criteria. All IMRT and VMAT plans selected for patient-specific QA were within the action limits suggested by TG-218. The fast-rotating O-ring linac and its preconfigured TPS are compliant with the international commissioning criteria of AAPM MPPG 5.a and AAPM TG-119. E2E measurements on heterogeneous anthropomorphic phantoms were within clinically acceptable tolerances. IROC Houston's audits satisfied the credentialing criteria. This work comprises the first extensive dataset reporting on the preconfigured fast-rotating O-ring linac.

A Fuzzy Inference System for Unsupervised Deblurring of Motion Blur in Electron Beam Calibration

This paper presents a novel method of restoring the electron beam (EB) measurements that are degraded by linear motion blur. This is based on a fuzzy inference system (FIS) and Wiener inverse filter, together providing autonomy, reliability, flexibility, and real-time execution. This system is capable of restoring highly degraded signals without requiring the exact knowledge of EB probe size. The FIS is formed of three inputs, eight fuzzy rules, and one output. The FIS is responsible for monitoring the restoration results, grading their validity, and choosing the one that yields to a better grade. These grades are produced autonomously by analyzing results of a Wiener inverse filter. To benchmark the performance of the system, ground truth signals obtained using an 18 μm wire probe were compared with the restorations. Main aims are therefore: (a) Provide unsupervised deblurring for device independent EB measurement; (b) improve the reliability of the process; and (c) apply deblurring without knowing the probe size. These further facilitate the deployment and manufacturing of EB probes as well as facilitate accurate and probe-independent EB characterization. This paper’s findings also makes restoration of previously collected EB measurements easier where the probe sizes are not known nor recorded.

Open charm measurements with the NA61/SHINE experiment at the CERN SPS

The strong interactions programme of the NA61/SHINE experiment at the CERN SPS has been extended through the use of new silicon Vertex Detector, which allows for reconstructing open charm particles. The detector was designed to identify those particles by means of a precise reconstruction of their primary and secondary vertices.An initial version of the Vertex Detector, called SAVD (Small Acceptance Vertex Detector), was installed end of 2016. It was operated in a Pb+Pb calibration beam time in 2016, and with Xe+La in 2017. A further Pb+Pb beam time is scheduled for late 2018. The first indications of a D0 peak were observed in the data obtained from the 2016 Pb+Pb run.This work introduces the physics motivation behind the open charm measurements, and the status of the analysis of the collected data on open charm production. Moreover, the plans of future open charm measurements in NA61/SHINE experiment and the related to upgrades of the vertex detector will be discussed.

Setup and Characterization of a 137CS Dosimetry Calibration Source in a Space-constrained Environment.

Proper characterization of Cs sources used for dosimeter calibration and performance testing is crucial for accurate and precise knowledge of air kerma rate and delivered dose. A 269 GBq Cs source was relocated to a new facility, which had a footprint of approximately 2.8 m × 3.6 m and a 3.4 m high ceiling. A small room size, such as in the new facility, may significantly increase backscatter from the walls or room return. Due to the limited source strength, a relatively close irradiation position of 1.00 m from the source was selected to decrease required exposure times. Proximity to the small but cylindrical source has the potential to alter the 1/r relationship (inverse square law) of air kerma rate with distance associated with point sources. Practical tutorials concerning dosimetry irradiation facilities are largely absent from the archival literature. For those reasons, standard characterization experiments were repeated multiple times, great care was taken with positioning, several experiments were added to the standard ones, an ion chamber and dosimeters were used rather than film for greater accuracy and precision, and practical details of the process were recorded. The impacts of room size and finite source dimensions were quantified and mitigated by the efforts reported here. Recommendations for simple but thorough facility characterization, beam calibration, and quality control resulted.

Monte Carlo and 60 Co-based kilovoltage x-ray dosimetry methods.

This work seeks to investigate new methods to determine the absorbed dose to water from kilovoltage x rays. Current methods are based on measurements in air and rely on correction factors in order to account for differences between the photon spectrum in air and at depth in phantom, between the photon spectra of the calibration beam and the beam of interest, or in the radiation absorption properties of air and water. This work aims to determine the absorbed dose to water in the NIST-matched x-ray beams at the University of Wisconsin Accredited Dosimetry Calibration Laboratory (UWADCL). This will facilitate the use of detectors in terms of dose to water, which will allow for a simpler determination of dose to water in clinical kilovoltage x-ray beams. A model of the moderately filtered x-ray beams at the UWADCL was created using the BEAMnrc user code of the EGSnrc Monte Carlo code system. This model was validated against measurements and the dose to water per unit air kerma was calculated in a custom built water tank. Using this value and the highly precise measurement of the air kerma made by the UWADCL, the dose to water was determined in the water tank for the x-ray beams of interest. The dose to water was also determined using the formalism defined in the report of AAPM Task Group 61 and using a method that makes use of a Co absorbed dose-to-water calibration coefficient and a beam quality correction factor to account for differences in beam quality between the Co calibration and kilovoltage x-ray beam of interest. The dose to water values as determined by these different methods was then compared. The BEAMnrc models used in this work produced simulations of transverse and depth dose profiles that agreed with measurements with a 2%/2 mm criteria gamma test. The dose to water as determined from the different methods used here agreed within 3.5% at the surface of the water tank and agreed within 1.8% at a depth of 2 cm in phantom. The dose-to-water values all agreed within the associated uncertainties of the methods used in this work. Both the Monte Carlo-based method and the Co-based method had a lower uncertainty than the TG-61 methodology for all of the x-ray beams used in this work. Two new dose determination methods were used to determine the dose to water in the NIST-matched x-ray beams at the UWADCL and they showed good agreement with previously established techniques. Due to the improved Monte Carlo calculation techniques used in this work, both of the methods have lower uncertainties compared to TG-61. The methods presented in this work compare favorably with calorimetry-based standards established at other institutions.

Nuclear resonant scattering for γ-beam characterization procedure at ELI-NP

The ELI-NP facility, currently being built in Bucharest, Romania, will deliver an intense and almost monochromatic γ beam with tunable energy between 0.2 MeV and 19.5 MeV in two different beamlines . An articulated beam characterization system will be installed downstream of the collimator of each line. The system will use, as calibration candles, a few selected nuclear levels whose fluorescence condition will be monitored by a Nuclear Resonance Scattering System (NRSS). The NRSS will use a peculiar double-readout approach in order to detect resonant events overwhelming background: both scintillation and Cherenkov photons produced inside the same crystals will be separately read. • The NRS system will play a crucial role in the characterization of the Eli-NP beam. • It will be able to give a precise absolute energy calibration of the gamma beam. • The determination of the resonance will be achieved using a matrix of BaF/LYSO crystals. • A novel double readout technique shows a very good background rejection power.

Gradient Tree Boosting-Based Positioning Method for Monolithic Scintillator Crystals in Positron Emission Tomography

Monolithic crystals are considered as an alternative for complex segmented scintillator arrays in positron emission tomography systems. Monoliths provide high sensitivity, good timing, and energy resolution while being cheaper than highly segmented arrays. Furthermore, monoliths enable intrinsic depth of interaction capabilities and good spatial resolutions (SRs) mostly based on statistical calibrations. To widely translate monoliths into clinical applications, a time-efficient calibration method and a positioning algorithm implementable in system architecture such as field-programmable gate arrays (FPGAs) are required. We present a novel positioning algorithm based on gradient tree boosting (GTB) and a fast fan beam calibration requiring less than 1 h per detector block. GTB is a supervised machine learning technique building a set of sequential binary decisions (decision trees). The algorithm handles different sets of input features, their combinations and partially missing data. GTB models are strongly adaptable influencing both the positioning performance and the memory requirement of trained positioning models. For an FPGA-implementation, the memory requirement is the limiting aspect. We demonstrate a general optimization and propose two different optimization scenarios: one without compromising on positioning performance and one optimizing the positioning performance for a given memory restriction. For a 12 mm high LYSO-block, we achieve an SR better than 1.4 mm FWHM.

Calibration of Therapy Level Ionization Chamber at &lt;sup&gt;60&lt;/sup&gt;Co Teletherapy Beam Used for Radiation Therapy

The accuracy and traceability of absorbed dose to water measurement of radiotherapy beam is a critical issue to achieve the curative outcome of cancer patients. The current dosimetry protocols for radiotherapy beams TRS-398, TG-51 and DIN-6800-2 are based on the calibration factor of ionization chamber in terms of absorbed dose to water for 60Co beam. The accuracy of the calibration factor of ionization chamber as well as output of radiotherapy beam is the primary requirements of precisional dose deliver to the tumor which is the QA part of radiotherapy dosimetry. In the present study, we have calibrated 9 different ionization chambers (8 thimbles and 1 parallel plate) of various active volumes for 60Co beam against reference standard NE2571 and compared with manufacturer’s values. The Percentage Depth Dose (PDD) and Output Factors (OF) of two cobalt units were measured with standard calibration system by following IAEA dosimetry protocol TRS-398 and compare with 6 MV photon beam from medical linear accelerator. The traceability of the dosimetry was verified by the participation of postal dose IAEA/WHO intercomparison program. The aim of the participation was to investigate uncertainties involved in the calibration of Ionization Chamber (IC) and absorbed dose measurement. The percentage of deviation relative to IAEA mean dose was found to be -0.2% (traceable limit ±5%), which shows an excellent agreement of calibration of beam as well as ionization chamber with international standard. The deviation of factors of ionization chambers between the measured and manufacturer’s values were found within 0.07-2.81% with an uncertainty of ±1.5% (k=1).

Calibration of Therapy Level Ionization Chamber at &lt;sup&gt;60&lt;/sup&gt;Co Teletherapy Beam Used for Radiation Therapy

The accuracy and traceability of absorbed dose to water measurement of radiotherapy beam is a critical issue to achieve the curative outcome of cancer patients. The current dosimetry protocols for radiotherapy beams TRS-398, TG-51 and DIN-6800-2 are based on the calibration factor of ionization chamber in terms of absorbed dose to water for 60Co beam. The accuracy of the calibration factor of ionization chamber as well as output of radiotherapy beam is the primary requirements of precisional dose deliver to the tumor which is the QA part of radiotherapy dosimetry. In the present study, we have calibrated 9 different ionization chambers (8 thimbles and 1 parallel plate) of various active volumes for 60Co beam against reference standard NE2571 and compared with manufacturer’s values. The Percentage Depth Dose (PDD) and Output Factors (OF) of two cobalt units were measured with standard calibration system by following IAEA dosimetry protocol TRS-398 and compare with 6 MV photon beam from medical linear accelerator. The traceability of the dosimetry was verified by the participation of postal dose IAEA/WHO intercomparison program. The aim of the participation was to investigate uncertainties involved in the calibration of Ionization Chamber (IC) and absorbed dose measurement. The percentage of deviation relative to IAEA mean dose was found to be -0.2% (traceable limit ±5%), which shows an excellent agreement of calibration of beam as well as ionization chamber with international standard. The deviation of factors of ionization chambers between the measured and manufacturer’s values were found within 0.07-2.81% with an uncertainty of ±1.5% (k=1).

P206] Gafchromic and alanine detectors for verification of field junctions in craniospinal proton irradiation

Purpose Radiotherapy is one of essential methods of treatment for medulloblastoma – a primitive neuroectodermal tumor growing in cerebellum. Proton craniospinal irradiations are recommended because of sparing of intermediate-to-low-dose to healthy tissues and reduction of side effects, including secondary cancers. Two laterally opposed cranial fields and several posterior spine fields are usually used for irradiation in medulloblastoma as well in conventional radiotherapy as in proton one. In this field configuration a potential dose inhomogeneity at the field junctions can appear. We have investigated the dose homogeneity in the junction areas using Gafchromic films and alanine detectors. Methods A clinical plan for an anthropomorphic phantom of a 5-year-old child have been prepared. There were two opposed lateral brain fields and 2 posterior spine fields. Therefore two field junctions were investigated. Then the phantom was equipped with alanine detectors and Gafchromic films at chosen positions mainly in junction areas and irradiated. Alanine doses were assessed using proton beam calibration (5–20 Gy). The calibration curve was designed upon developed protocol based on ISO/WD 15566.1 document. Alanine doses were then compared with doses in the treatment plan. Gafchromic films were analyzed using in-house developed AnalyseGafchromic software allowing to calculate dose based on triple channel calibration and apply corrections on scanner spatial inhomogeneity and scan-to-scan instability. Finally, the measured 2D dose distributions were compared with dose planes exported from TPS (Treatment Planning System) using gamma index analysis. Results The compatibility of alanine doses and TPS doses was at the level of 1%. For all the dose planes measured with Gafchromic passing rates of gamma index test (3%/3 mm) was higher than 95%. Conclusions Patients with medulloblastoma may benefit greatly from proton radiotherapy, however the main condition for a successful treatment is a careful and accurate field junctions, where all the uncertainties of beam model in TPS, CT calibration curve and Patient Positioning may affect the dose delivered to the patient. We have proved that Gafchromic films and alanine detectors can be successfully used for complex system check for ability to irradiate the target with sufficient accuracy.

CdZnTe detectors for gamma spectroscopy and x-ray photon counting at 250 × 106 photons/(mm2 s)

Using the traveling heater method, we have developed commercial CdZnTe (CZT) crystal growth, fabrication, and in-house test technologies for both, photon-starved gamma spectroscopic sensors and high-flux x-ray photon-counting for medical imaging and other applications. We compare the performance of different CZT material types for gamma spectroscopy and for high-flux x-ray imaging. We demonstrate single-threshold photon counting and basic imaging capability of pixelated CZT detectors at the highest x-ray fluxes we could generate in-house, i.e., ∼250 × 106 photons/(mm2 s). We show that the test system can be used for universal, absolute flux calibration of x-ray beams based on an accurate pile-up fitting algorithm. The detectors also perform spectroscopically under high-flux, when tested with energy discriminating electronics. A brief investigation on the effects of leakage, photo, and excess currents including their temporal behavior is also presented. Sub 1% uncorrected single-pixel resolution of the 662 keV 137Cs full energy peak was achieved with the gamma spectroscopy optimized material, fabricated into pixelated sensors.