We prove the existence of a bounded H ∞-calculus in weighted L p -Sobolev spaces for a closed extension A T of a differential operator A on a conic manifold with boundary, subject to a differential boundary condition T, provided the resolvent (λ − A T )−1 exists in a sector Λ ⊂ ℂ and has a certain pseudodifferential structure that we describe. In case A T is the minimal extension of A, this condition reduces to parameter-ellipticity of the boundary value problem . Examples concern the Dirichlet and Neumann Laplacians.