Abstract The conventional method of fixed boundaries for predicting erosion inadequately reflects the erosion characteristics of centrifugal pumps under realistic operating conditions. In this research, we employ the dynamic boundary method, considering the influence of changes in wall morphology due to erosion on the flow field. We utilize the Euler-Lagrange approach and the E/CRC erosion model, incorporating a dynamic boundary geometry reconstruction strategy, to predict the erosion characteristics of the IS80-50-315 single-stage single-suction centrifugal pump. Solid-liquid two-phase flow calculations are conducted on the pump to predict erosion characteristics under varied operating conditions. The results show that the dynamic boundary-based progressive erosion prediction method realistically forecasts the erosion characteristics of the overflow wall and captures the evolution of blade morphology with erosion time. Erosion intensity on the blade suction surface significantly surpasses that on the pressure surface, guided by particle distribution characteristics in the centrifugal pump flow channel. Particle diameter primarily influences the erosion position of centrifugal pump blades; smaller particles induce erosion in the middle region of the blade, while an increase in particle diameter shifts the severe erosion position towards the impeller outlet direction. At a consistent particle diameter, higher particle concentrations correspond to elevated erosion rates in the blade area. We establish a relationship between the blade mass loss rate and erosion time during 2500 hours of pump operation at the design condition, introducing the blade mass loss rate for convenient assessment and prediction of blade damage in the centrifugal pump.