Calcium Citrate Research Articles

SUN-610 Thyroid Storm and Hypoparathyroidism Caused by Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Carcinoma (ATC) has an incidence of ≤ 2/1,000,000 and mean diagnosis age of 65 years (1). Fewer than 10% are <50 years (2,3). Hypoparathyroidism secondary to destruction of the gland from malignant invasion is rare, accounting for ≤0.7% of all cases (4). The estimated incidence of thyroid storm is <0.2/100,000 per year (5). A 48-year-old woman presents with odynophagia, night sweats, exertional dyspnea, diarrhea and swelling of the neck. A CT shows a large solid mass with cystic pockets in the thyroid measuring 12.5 cm, and multiple lung nodules consistent with metastatic cancer. She is admitted with an initial Burch HB-Wartofsky Score (BWS) of 10. TSH is <0.01 mIU/L; free T4, 2.91 ng/dL; and T3, 6.44 pg/mL. Thyroid fine needle aspiration biopsy shows malignancy with a differential diagnosis of ATC versus metastatic squamous cell carcinoma. A subsequent core thyroid biopsy confirms ATC. The patient developed compressive dyspnea that resulted in hypoxic cardiac arrest followed by atrial fibrillation. She experienced persistent tachycardia, hyperthermia (101.7 F), and coma. She is diagnosed with thyroid storm (BWS of 50). Thyroid antibodies were negative. She responds to high-dose glucocorticoids, beta blockers, and propylthiouracil. Three days later, thyroid function tests, tachycardia, and fever improves, but coma persists. The ATC continues to enlarge rapidly. Fourteen days after admission, she develops hypocalcemia (5.2 mg/dL), and intact Parathyroid Hormone (iPTH) was 6.3 pg/mL. Phosphorus and magnesium are normal. Hypoparathyroidism is attributed to malignant infiltration and destruction of the parathyroid glands. She responds to enteral calcitriol and calcium citrate. Her family opts for comfort measures after 19 days of coma. Conclusion: ATC may present with thyrotoxicosis and progress to thyroid storm. Hypoparathyroidism may occur due to invasion of the parathyroid glands.

Absorption Characteristics of Novel Compound Calcium Carbonate Granules: Effects of Gastric Acid Deficiency and Exogenous Weak Acids.

Calcium carbonates are commonly administered as supplements for conditions of calcium deficiency. We report here pharmacokinetic characteristics of a novel formulation, calcium carbonate compound granules (CCCGs), forming complexes of calcium carbonate and calcium citrate in water. CCCGs were compared to a kind of commonly-used calcium carbonate D3 preparation (CC) in the market in 5-week-old mice that had been treated with omeprazole, to suppress gastric acid secretion, and in untreated control mice. The results showed that: (1) CCCGs had better water solubility than CC in vitro; (2) In control mice, calcium absorption rates after CCCGs administration were comparable to those after CC administration; (3) Inhibition of gastric acid secretion did not affect calcium absorption after CCCGs, but moderately decreased it after CC; (4) The presence of phytic acid or tannin did not affect calcium absorption rates after CCCGs but did for CC; and (5) In normal mice, CCCGs did not inhibit gastric emptying and intestinal propulsion, and did not alter the gastrointestinal hormones. The results suggest that CCCGs may be therapeutically advantageous over more commonly used calcium supplement formulations, particularly for adolescents, because of their stable calcium absorption characteristics and their relatively favorable adverse effect profile.

One‐step synthesis of in situ nanocarbon‐containing calcium aluminate cement in reducing atmosphere

AbstractIn order to overcome the problems caused by poor water wettability/dispersion and oxidation resistance of carbons for improving properties of carbon‐containing refractory castables, we prepare in situ nanocarbon‐containing cement through the carbon‐bed sintering method with calcium citrate tetrahydrate (CCT, C12H10Ca3O14·4H2O) and Al2O3 as raw materials, and FeCl3 as a catalyst. In this paper, the carbonization process of CCT was analyzed by X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and thermogravimetric analysis coupled with a FTIR. In addition, the synthesized cement was characterized through XRD, Raman spectroscopy, field‐emission scanning electron microscopy, and high‐resolution transmission electron microscopy. The results show that the in situ carbon was generated through carbonization of calcium aconitic acid which was generated by pyrolysis of CCT, accompanying with overflowing of H2O, CO2, CO, and CH4. Interestingly, as the sintering temperature increases, the freshly generated carbons were transformed into nanofiber and nanoflake carbons under the action of Fe catalyst. After sintering at 1500°C for 4 hours, the phase compositions of the synthesized product approached to that of the commercial cement Secar71, and the in situ carbons with nanofiber and nanoflake morphologies dispersed in calcium aluminate grains.

Hot Pepper viii. Reduction of Microbial Spoilage and Physio-chemical Deterioration in Processed Caribbean Peppers

The quality in the small producers&amp;rsquo; hot pepper industry is affected by microbial and thermal processing which reduces the physio-chemical qualities of the final product particularly colour retention and to a lesser extent pungency. A series of studies explored the causes and evaluated some protocols to reduce microbial infection and the loss of pigment using varying sealant caps of vegetable oil and sodium chloride, in addition to preserving agents (calcium chloride, ascorbic acid, sodium benzoate, sodium chloride, and calcium citrate). The result confirmed that red pepper mash in 100g CaCl2 (calcium chloride) submerged under vegetable oil sealant cap retained &amp;ldquo;L&amp;rdquo;, &amp;lsquo;a&amp;rsquo;, &amp;lsquo;b&amp;rsquo; colour coordinates as the fresh peppers beyond 100 days with no loss of colour, pungency and flavour.

Efficient production of isosorbide from sorbitol dehydration over mesoporous carbon-based acid catalyst

Isosorbide, a renewable platform molecule from biomass-derived sorbitol cyclodehydration has attracted much attention over the years. The high yield production of isosorbide from sorbitol by an efficient heterogeneous catalyst under mild conditions is still a tough challenge. Herein, a mesoporous carbon-based acid MC-PhSO3H was prepared without assistant of additional templates via grafting benzenesulfonic acid groups to carbonized calcium citrate, and used as a recyclable catalyst to catalyze the dehydration of sorbitol to isosorbide under the solvent-free condition. The MC-PhSO3H exhibited highly efficient catalytic ability in isosorbide production with the yield of 82.7% at relatively mild reaction temperature of 160 °C within 1.5 h, which was superior to that of homogeneous H2SO4 and typical strong solid acid SO42−/ZrO2. The various characterization techniques such as N2 adsorption-desorption, NH3-TPD, pyridine-infrared spectroscopy and sulfur elemental analysis revealed that the good catalytic performance of MC-PhSO3H was determined by its mesoporous structure with large surface area and pore volume, suitable hydrophilicity/hydrophobicity character, as well as high density of strong Brønsted acid sites. More importantly, MC-PhSO3H could be readily recovered and reused for five consecutive cycles.

Editorial Comment

This manuscript by Canales et al describes the effects of calcium and vitamin B6 supplementation on oxalate excretion in a rat Roux-en-Y gastric bypass model. Medical advances in the treatment of calcium oxalate stones have only made modest gains over the past several decades and the common misconception that excessive calcium in one's diet exacerbates stone formation has been hard to overcome. While this study deals specifically with enteric hyperoxaluria and Roux-en-Y gastric bypass, it does hold similarities between other calcium oxalate stone forming patients. The primary principles proven in this rat model indicate the importance of oral dietary calcium supplementation in patients with excessive oxalate in the gut. In the case of enteric hyperoxaluria, calcium becomes saponified by excessive fat in the intestine and is therefore unavailable to bind to dietary oxalate. In this study, dietary calcium supplementation decreased urinary oxalate excretion by 28% without a rise in urinary calcium. This same principle is often true in many calcium oxalate stone formers. Dietary supplementation with either milk or calcium-fortified orange juice taken with meals is an important treatment to reduce urinary oxalate. Prescribing calcium citrate to your stone forming patient with hyperoxaluria is also beneficial and should be in the armamentarium of all practicing urologists.

Hierarchical Porous Carbon Synthesized from Novel Porous Amorphous Calcium or Magnesium Citrate with Enhanced SF6 Uptake and SF6/N2 Selectivity

The emission of greenhouse gases such as CO2 and SF6 is believed to contribute significantly toward global warming. One way to reduce their release is by adsorption at point sources using a suitable adsorbent. In this work we present the synthesis of two hierarchical porous carbon materials (referred to as PC-CaCit and PC-MgCit) with a high uptake of SF6 (5.23 mmol/g, 0 °C, 100 kPa) and a reasonable uptake of CO2 (>3 mmol/g). PC-CaCit and PC-MgCit were obtained by pyrolysis of the most porous calcium citrate and magnesium citrate ever reported, which were synthesized by us. The Langmuir specific surface area of PC-CaCit and PC-MgCit was over 2000 m2/g (BET surface area also close to 2000 m2/g). We characterized PC-CaCit and PC-MgCit using a range of advanced characterization techniques including N2 adsorption, high-resolution electron microscopy, powder X-ray diffraction, and X-ray photoelectron spectroscopy. PC-CaCit and PC-MgCit also showed a SF6-over-N2 selectivity of ∼33 at 0 °C (100 kPa), good cyclic...

Керамика в системе Са2Р2О7—Са(РО3)2, полученная обжигом образцов из твердеющих смесей на основе цитрата кальция и монокальцийфосфата моногидрата

Керамика в системе Са2Р2О7—Са(РО3)2, полученная обжигом образцов из твердеющих смесей на основе цитрата кальция и монокальцийфосфата моногидрата

Iron/Nitrogen co-doped mesoporous carbon synthesized by an endo-templating approach as an efficient electrocatalyst for the oxygen reduction reaction

Abstract Iron/Nitrogen-doped carbon catalysts are considered to be one of the most promising candidates to replace platinum-based catalysts for the oxygen reduction reaction in the cathode of the fuel cell. Herein, we demonstrate a simple and cost-effective strategy for the fabrication of Fe-N-C-mesoporous-carbons involving the carbonization of calcium citrate followed by a post-treatment with urea and ammonium sulfate iron (II). The synthesized materials exhibit high values of surface area, large nitrogen and iron contents. The iron is present in two configurations: i) γ-iron phase and ii) iron coordinated to nitrogen (Fe-Nx). When used as an electrocatalyst in basic electrolyte, the Fe-N-C material predominantly catalyzes the four-electron pathway with an onset potential of 0.91 V and a half-wave potential of 0.81 V. In acidic electrolyte, the optimized catalyst exhibits an onset potential of 0.73 V. The experimental results show that the N-functionalities and the Fe-N coordination sites play a major role in catalytic performance in both kinds of electrolytes and that the ɣ-iron phase has little or no catalytic effect. In this regard, pure N-doped carbon shows to be better catalyst than pure Fe-doped carbon. Hence, these results provide useful guidelines for the development of highly active and cost-effective ORR catalysts.

Citrate reduced oxidative damage in stem cells by regulating cellular redox signaling pathways and represent a potential treatment for oxidative stress-induced diseases

Chemical substances containing citrate such as calcium citrate, citrate esters and citric acid exhibit anti-oxidant and anti-inflammatory properties in different cells and tissues. However, data on the anti-oxidant and anti-inflammatory properties and mechanisms of action of citrate are insufficient. In this study, we systematically evaluated the anti-oxidant capacity of citrate using chemical, cellular and animal assays. Citrate showed a stable molecular structure and did not directly react with oxides. Citrate exerted protective and anti-apoptotic effects on BMSCs and also showed significant inhibitory effects on the oxidative stress and inflammatory reactions in the rat air pouch model. By using proteomics, we found that PPARγ contributed to the upregulation of various free radical scavenging proteins and the downregulation of diverse components of the inflammatory responses. Citrate-regulated global PPARγ expression was evidenced by the significant increase expression of PPARγ in PC12 cell line. Our results provide novel insights into the role of citrate in regulating cellular redox signaling and the function of PPARγ signaling in this process and also provide basic molecular cell biology information to improve the applications of biomaterials or stem cells as treatments for oxidative stress-induced degenerative diseases and inflammatory diseases.

Co- and self-activated synthesis of tailored multimodal porous carbons for solid-phase microextraction of chlorobenzenes and polychlorinated biphenyls

Highly sensitive solid-phase microextraction (SPME) of broad-spectrum organic micropollutants is a significant challenge due to the limited available pore sizes and pore size distributions (PSDs) of the probes. In this work, we synthesized novel multimodal porous carbons (MPCs) using facile and environment-friendly route for the first time, through direct carbonization of a potassium citrate and calcium citrate mixture. The co-carbonization process formed hierarchical structures with super-high specific surface areas (up to 3270 m2 g−1) and pore volumes (up to 1.79 cm3 g−1). The PSD was easily controlled through adjustment of the mixture ratios of potassium citrate to calcium citrate. Moreover, the MPCs were partly graphitized, and showed great thermal stability (>450 ℃). MPC-coated probes were prepared and applied to extract chlorobenzenes (CBs) and polychlorinated biphenyls (PCBs) with improved performance, higher extraction capacity than commercial carboxen/polydimethylsiloxane probe. Under optimized conditions, a sensitive detection method for CBs and PCBs was developed by a MPC-coated probe coupled with gas chromatography-electron capture detector. Finally, this method was successfully applied to analyze real environmental water samples with satisfactory recoveries (85.56%–104.30%). The findings are expected to broaden our perspectives for improved design of efficient porous materials for broad-spectrum SPME and other applications.

Coupled diffusion in aqueous citric acid + calcium citrate solutions

Taylor dispersion is used to measure ternary mutual diffusion in aqueous citric acid(1) + calcium citrate(2) solutions at 25 °C. Main diffusion coefficients D11 and D22 reach values 25% to 60% larger than the respective binary diffusion coefficients of aqueous citric acid and calcium citrate. Of additional interest, cross-coefficient D12 is large and negative, indicating that each mole of diffusing calcium citrate counter-transports up to two moles of citric acid. Nernst-Planck (NP) equations are used to relate the fluxes of the citric acid and calcium citrate components to the fluxes of the solution species: molecular citric acid (H3Cit) and its dissociation products (H+, H2Cit−, HCit2− and Cit3− ions), Ca2+ ions, and calcium complexes produced by ion association (CaCit−, CaHCit, CaH2Cit+). The NP analysis identifies key roles in the coupled diffusion of citric acid and calcium citrate played by ion association and by ion migration in the electric field generated by hydrogen-ion concentration gradients.

Chronic Ingestion of Sodium and Potassium Bicarbonate, with Potassium, Magnesium and Calcium Citrate Improves Anaerobic Performance in Elite Soccer Players.

Anaerobic power and anaerobic capacity significantly influence performance in many sport disciplines. These include prolonged sprints in athletics, swimming, or cycling, and other high intensity intermittent sports, such as soccer or basketball. Considering the association of exercise-induced acidosis and fatigue, the ingestion of potential buffering agents such as sodium bicarbonate, has been suggested to attenuate metabolic acidosis and improve anaerobic performance. Since elite soccer players cover from 200 to 350 m while sprinting, performing 40–60 all out sprints during a game, it seems that repeated sprint ability in soccer players is among the key components of success. In our experiment, we evaluated the effectiveness of chronic supplementation with sodium and potassium bicarbonate, fortified with minerals, on speed and speed endurance in elite soccer players. Twenty-six soccer players participated in the study. The subjects were randomly divided into two groups. The experimental group was supplemented with sodium bi-carbonate and potassium di-carbonate fortified with minerals, while the control group received a placebo. The athletes were tested at baseline and after nine days of supplementation. Anaerobic performance was evaluated by the Repeated Anaerobic Sprint Test (RAST) protocol which involved 6 × 30 m max sprints, separated by 10 s of active recovery. Resting, post ingestion and post exercise concentrations of HCO3− and blood pH were measured as well as lactate concentration. The current investigation demonstrated a significant increase in RAST performance of elite soccer players supplemented with sodium and potassium bicarbonate along with calcium phosphate, potassium citrate, and magnesium citrate ingested twice a day over a nine-day training period. The improvements in anaerobic performance were caused by increased resting blood pH and bicarbonate levels.

Calcium lactate as an attractive compound to partly replace salt in blue-veined cheese

In addition to their high sodium content, cheeses are thought to induce an acid load to the body, which is associated with deleterious effects on consumers' health. Our objective was to explore the use of alkalinizing salts in partial substitution of NaCl to reduce both the sodium content and the acid-forming potential of cheese, without altering its sensory properties. Blue-veined cheeses were produced under industrial conditions, using brine salting followed by dry salting with a 4:1 (wt/wt) mixture of calcium lactate:NaCl or calcium citrate:NaCl. Sodium chloride was used in 2 granulometries: coarse (control treatment) and fine, to obtain homogeneous mixtures with the organic salts. Cheeses were then ripened for 56 d. No major appearance defects were observed during ripening. Calcium lactate substitution decreased the Na content of the cheese core by 33%, and calcium citrate substitution increased the citrate content of the cheese core by 410%, respectively, compared with fine NaCl. This study highlighted the substantial role of salt granulometry in sodium content, with the use of the coarse salt reducing the sodium content by 21% compared with fine salt. Sensory profiles showed nonsignificant differences in bitter and salty perceptions of salt-substituted cheeses with calcium lactate and calcium citrate compared with control cheeses. The use of calcium lactate should be considered to reduce the sodium content and improve the nutritional quality of cheeses while maintaining the sensory quality of the products. Alkalinizing organic salts could replace the acidifying salts KCl or CaCl2, which are currently used in salt replacement and are not recommended for consumers with renal disease. The method described here should be considered by cheese-making producers to improve the nutritional quality of cheese. Additional nutritional optimization strategies are suggested.

New Sources of Calcium (Chicken Eggshells, Chelates) - Preparation of Raw Material and Tablets.

There are many calcium supplements available in the market, especially those containing calcium in the form of carbonate, which unfortunately is not absorbed by the body to a sufficient degree. Therefore, an attempt was made to prepare new sources of calcium, consuming the chicken eggshells as natural raw materials, which were used in preparation of tablets containing calcium carbonate and calcium citrate as well as tablets with calcium carbonate and calcium bisglycinate. The influence of raw material properties on the pharmaceutical availability of calcium from the obtained tablets was investigated. Based on the obtained calcium release profiles from the prepared tablets, it was found that the optimal source of calcium is a preparation containing calcium from chicken eggshells. It was found that both chicken eggshells and calcium bisglycinate (chelate) may be new, prospective sources of calcium. Calcium citrate prepared using eggshells as starting materials and bisglycinate is completely released within no more than 150 minutes. In turn, calcium carbonate added to calcium bisglycinate statistically significantly prolonges the release of calcium ions to 4 hours.

Effect of calcium citrate vs calcium carbonate on elevated parathyroid hormone after Roux-en-Y gastric bypass. A double-blinded, randomized trial.

Following Roux-en-Y gastric bypass (RYGB), elevated parathyroid hormone (PTH) levels potentially harmful to bone health are commonly observed. Owing to assumed superior absorption, calcium citrate is often recommended over calcium carbonate following RYGB for the treatment of elevated PTH. We aimed to investigate the impact of either calcium carbonate or calcium citrate (1200mg elementary calcium) in patients with elevated PTH levels following RYGB. Clinical, double-blinded, randomized controlled trial of a 12-week duration at a Danish University Hospital. Thirty-nine (no drop out) RYGB operated patients with elevated PTH levels (PTH>6.9pmol/L) and normal plasma levels of calcium and 25-hydroxyvitamin D were randomized to either calcium carbonate or calcium citrate (1200mg elementary calcium/daily). We assessed change in PTH as the primary outcome. The effect of the two calcium formulations on change in PTH was comparable and neutral: -1.9% (calcium citrate) vs +0.9% (calcium carbonate), P=0.680. Compared to the carbonate-treated group, the following bone turnover markers decreased significantly in the citrate-treated group: procollagen I N-terminal propeptide (-16.6% vs -3.2%, P=0.021), osteocalcin (-17.2% vs -4.3%, P=0.007) and bone-specific alkaline phosphatase (-5.9% vs 3.7%, P=0.027) and remained significantly decreased after multivariable adjustment. Increasing the dose of calcium supplementation in RYGB operated patients with slightly elevated PTH levels does not normalize PTH levels, regardless of the type of supplement. Our results do not support recommending supplementation with calcium citrate over calcium carbonate in RYGB patients.

Bread Staling: Changes During Storage Caused by the Addition of Calcium Salts and Inulin to Wheat Flour

The objective of this work was to study changes in staling parameters of wheat bread formulated with different calcium salts (carbonate, citrate, or lactate) and inulin. The moisture content and texture of crumbs were studied. Moreover, the effect of calcium and inulin levels on crumb firmness during storage was estimated by fitting the Avrami equation. Starch retrogradation and the amylose-lipid complex were evaluated by differential scanning calorimetry (DSC) and X-ray diffraction. Crumbs with high inulin content retained water during storage, regardless of the nature of the calcium salt used. In addition, they presented lower loss of elasticity and cohesiveness than the control crumb. Crumbs with calcium citrate and low inulin content produced the lowest increase in crumb firmness. In addition, elasticity and cohesiveness of crumbs containing low amount of inulin and organic salts were almost maintained. The salt that favored the retrogradation process was calcium lactate with high inulin content, evidenced by the shorter half-time obtained with the kinetic studies. Also, the increase in crystallinity of B-type starch in crumbs with organic calcium salts and high inulin content, correlates with the highest values of retrogradation enthalpy obtained by DSC.

CT-Based Diagnosis of Low Vertebral Bone Mineral Density Is Associated with Hypercalciuria and Hypocitraturia on Opportunistic Imaging

Studies have demonstrated associations between nephrolithiasis and systemic conditions, including low bone mineral density (BMD), which may correlate with hypercalciuria in kidney stone formers (KSFs). Traditionally, low BMD is diagnosed with dual-energy X-ray absorptiometry. As a noncontrast CT (NCCT) scan is typically part of a stone evaluation, our objective was to evaluate the association of NCCT-based vertebral BMD with 24-hour urine parameters in KSF. This is a retrospective analysis of 99 KSFs who had CT imaging and 24-hour urine studies. For each patient, BMD was estimated at the L1 vertebral body and CT attenuation measured in HU. A threshold of 160 HU was chosen to distinguish normal from low BMD. Univariate and multivariate logistic regression analysis was performed to compare patients with low and normal BMD. Multivariate linear regression was performed to assess for variables associated with 24-hour urine parameters. Patients with low BMD had higher 24-hour urine calcium (219 vs 147 mg/day, p < 0.0001) and larger stone volume (259 vs 78.4 mm3, p = 0.009). Multivariate analysis demonstrated age >60 years (odds ratio [OR] 9.3, p < 0.0001) and hypercalciuria (OR 4.34, p = 0.004) correlated with low BMD. Linear regression demonstrated that lower BMD was associated with higher urinary calcium (β-coefficient -0.268, p = 0.009) and lower urinary citrate (β-coefficient 0.332, p = 0.01). CT-based diagnosis of low mineral bone density is associated with derangement in 24-hour urine calcium and citrate in KSFs, as well as larger stone volumes.

Calcium citrate insolubilization drives the fouling of falling film evaporators during the concentration of hydrochloric acid whey

When dairy powders are produced, the mineral fraction undergoes strong modifications during the vacuum concentration step, leading to the fouling of falling film evaporators. The objective of this study was to determine the nature of the deposits formed during the vacuum concentration of two fouling and highly mineralized products: hydrochloric acid whey and lactic acid whey. These products mainly differ in terms of their mineral composition: lactic acid whey contains a high level of lactic acid and traces of citrate, whereas hydrochloric acid whey contains citrate and no lactic acid. Concentrates at different concentration factors were produced using a pilot-scale falling film evaporator. The compositions of the fouling deposits as well as the precipitates present in the concentrates were deduced from the analytical determination of the composition of the concentrates and their respective diffusible phases. The behavior of the mineral fraction of both acid wheys during concentration was shown to be very different. In the case of hydrochloric acid whey, experimental results suggested a deposition of calcium and citrate ions in the evaporator as well as their precipitation in the highly concentrated products. On the contrary, neither mineral deposition nor precipitation occurred during the concentration of lactic acid whey. This study underlined the key role of citrate ions in the fouling of evaporators during the concentration of hydrochloric acid wheys.

EFFECT OF FOLIAR SPRAY WITH SOME PLANTS EXTRACTS AND DIFFERENT CALCIUM SOURCES ON PRODUCTIVITY AND QUILTY OF STRAWBERRY FRUITS. I. VEGETATIVE GROWTH , PRODUCTIVITY AND FRUIT QUALITY

ABSTRACT: Two pots experiments were conducted in Baramoon Res. Station, Dakahlia Governorate, Egypt during of 2014/2015 and 2015/2016 seasons to study the effect of some exogenous plant extracts and different calcium sources on growth , productivity and fruit quality of strawberry. Three available plants extract namely, green tea, thyme and mushroom at 2 ml /l of each as well as chitosan at 1% and different calcium sources, i.e., calcium chloride (1 %), calcium citrate (2.5 ml/l) and calcium nitrate ( 0.5 ml /l) were evaluated plus control treatment ( spraying with tap water) . The obtained results could be summarized as follows: All treatments of plant extracts, chitosan and different calcium sources had significantly increased vegetative growth, yield and its components and fruits quality of strawberry than control treatment ( sprayed with tap water) in both seasons. Spraying strawberry plants with green tea extract at 2 ml / l gave the maximum values of all vegetative growth parameters, such as plant height, fresh weight/ plant, number of leaves per plant and leaf area, concentrations of chlorophyll a and total chlorophyll in leaf tissues, both number of runners, flowers and crown / plant, crown diameter/plant and total yield/ plant as well as average fruit weight, also the highest fruit quality , i.e., pectin, Vit. C , TSS, total sugars, reducing and nun reducing and lowest values of total acidity, followed by spraying with mushroom extract at 2 ml / l or calcium nitrate at 0.5 ml/l . The increases in total yield/ plant were about 78.94 and 68.48 % for spraying plants with green tea extract and 55.93 and 62.56 % for spraying plants with calcium nitrate over unsprayed plants (control treatment ) in the 1st and 2nd seasons, respectively. Conclusively, from the foregoing results of this study, it could be concluded that, under the same conditions , spraying strawberry plants with plants extracts such as green tea or mushroom extracts at 2 ml / l or calcium nitrate at 0.5 ml/l were the best treatments for increasing growth , yield and gave the best fruits quality .