Calcification In Carcinoma Research Articles

Calcified Carcinoma of the Gallbladder with Calcified Nodal Metastasis Presenting as a Porcelain Gallbladder: A Case Report

Porcelain gallbladder is regarded as a risk factor of gallbladder cancer. A porcelain gallbladder with calcified regional lymph nodes was found using computed tomography (CT) and magnetic resonance imaging (MRI) in a 43-year-old man who presented with nausea, vomiting, and abdominal pain. His cholecystectomy specimen showed diffuse wall thickening and contained small gallstones. Histological examination revealed diffuse infiltrative adenocarcinoma with extensive intratumoral calcification (calcified carcinoma). The majority of the calcified material was located within or replaced the tumor glands, and was not found in the stroma. A lymph node was totally replaced with a calcified metastatic adenocarcinoma. To the best of our knowledge, only one case of calcified lymph node metastasis from a calcified carcinoma of the gallbladder has been previously reported in the literature. We herein add a case of calcified carcinoma of the gallbladder with calcified lymph node metastasis, presenting as a porcelain gallbladder on CT and MRI.

CT demonstration of calcification in carcinoma of the lung: Grewal RG, Austin JHM. PHC of North Western Pennsylvania, 1720 Holland St., Erie, PA 16503. J Comput Assisted Tomogr 1994;18:867–871

CT demonstration of calcification in carcinoma of the lung: Grewal RG, Austin JHM. PHC of North Western Pennsylvania, 1720 Holland St., Erie, PA 16503. J Comput Assisted Tomogr 1994;18:867–871

CT demonstration of calcification in carcinoma of the lung.

Our goal was to assess the diagnostic significance of calcification in carcinoma of the lung, as seen on CT. We prospectively identified 500 consecutive patients with the provisional clinical diagnosis of lung cancer, who underwent CT examination of the chest from 1987 to 1991. Fifty-three (10.6%) of the 500 CT examinations revealed intratumoral calcification. When these 53 patients were reviewed retrospectively in 1992, CT examinations were available for 39, each with microscopic proof of primary carcinoma of the lung. Tumors were assessed for histologic subtype, size, and location and compared with a control group of the last 115 noncalcified, proven, primary carcinomas of the lung in the series. Intratumoral calcification seen on chest CT was assessed for location, extent, and pattern. The calcified tumors tended to be large (6.2 +/- 3.0 cm, mean diameter +/- SD) compared with the noncalcified tumors (4.4 +/- 2.3 cm) (p = 0.0001). The calcified tumors were central in 28 (72%) and peripheral in 11 (28%) patients. The noncalcified tumors were central in 52 (45%) and peripheral in 63 (55%) patients (p = 0.007). Punctate pattern of calcification correlated marginally with small cell carcinoma (p = 0.07). Histologic subtype showed no correlation with intratumoral location or extent of calcification. Calcification is identified in 10% of lung cancer, does not predict histologic subtype, and tends to occur in large, central tumors.

Solitary pulmonary nodules: comparison of classification with standard, thin-section, and reference phantom CT.

Standard, thin-section, and reference phantom computed tomography (CT) were performed to evaluate 75 consecutive patients with solitary pulmonary nodules. Follow-up was available for 62 nodules in 59 patients; 53 of the nodules were benign and nine were malignant. Twenty-one of the 62 nodules were assessed as benign with thin-section CT, while 33 of the 62 nodules were assessed as benign with reference phantom CT. Two of the nodules classified as benign with both thin-section and reference phantom CT proved to be malignant (a peripheral, ossified carcinoid and a 3.5-cm-diameter calcified carcinoma). The sensitivity of reference phantom CT (58%) for classification of benign nodules was higher than the sensitivity of thin-section CT (36%). The sensitivity of standard CT was lowest (12%). The presence of fat at thin-section CT was a reliable criterion for benignancy in six hamartomas. While both thin-section and reference phantom CT were useful in the identification of benign pulmonary nodules, reference phantom CT increased sensitivity by 22% compared with thin-section CT.

CT demonstration of calcification in carcinoma of the lung.

Radiologic visualization of calcification within lung cancer is uncommon and may cause confusion and misdiagnosis. For this reason, we reviewed CT records of 353 patients undergoing initial evaluation of lung cancer for the presence of calcification within the tumor, both to document this finding and to estimate its prevalence. Twenty patients (6%) whose records indicated that CT showed calcification were identified, and their chest radiographs and CT scans were analyzed. Patients were included in the study if calcium was seen within the tumor on noncontrast pretreatment CT scans and if pathologic data were available. There were 15 lung and five mediastinal tumors. Fourteen were 5 cm or greater in diameter; three were between 3 and 5 cm, and three were 2 cm or smaller. Cell types of the tumors included small-cell carcinoma (eight patients), squamous cell carcinoma (seven patients), adenocarcinoma (four patients), and undifferentiated carcinoma (one patient). Patterns of calcification were amorphous (eight patients), punctate (10 patients), and reticular (two patients). Extent of tumor calcification and distribution (central, peripheral, or diffuse) did not correlate with cell type or size of the lesion. The visualization of calcium on chest radiographs and CT scans does not alone exclude the diagnosis of bronchogenic carcinoma.

A calcified carcinoma of the lung and intracerebral metastasis

A case of a calcified carcinoma of the lung which later developed a large diffusely calcified brain metastasis is reported. Considerations which caused us to suspect a malignant lesion at presentation, although diffusely calcified, are discussed.

Roentgenographic calcifications in carcinoma of the thyroid.

Calcifications were detected on roentgenography of the neck in a 5-year-old girl with a thyroid nodule. The lesion was subsequently found to be a papillary adenocarcinoma of the thyroid containing psammoma bodies. We found roentgenography of the neck to be useful in the differential diagnosis of thyroid nodules.

Mammography in Singapore.

Summary An analysis is made of 223 cases of mammography seen in the Outram Road General Hospital, Singapore, from October 1967 to May 1971. All cases had histological confirmation. There were 90 (40‐36%) cases of carcinoma. The mammographic diagnosis, when combined with clinical examination, was 93% correct. The diagnosis based on the reading of mammograms alone was 71 % correct. Calcification in carcinoma occurred in 27% of cases, but only 11 % showed fine sand‐like calcifications. The skin was thickened in 22% of cases. There were 56 cases (25‐11%) of fibroadenoma. The accuracy of mammography taken in conjunction with clinical findings was 32%; mammography alone gave a 30% accuracy. Calcification was seen in 11 % of cases. Forty cases (17–94%) of mammary dysplasia were seen. Mammography in association with clinical examination was 32% correct; mammography alone was 30% correct. Thus the accuracy rates for both fibroadenoma and for mammary dysplasia were much lower than for carcinoma. An assortment of other non‐malignant conditions numbered 37 cases (16–59%). The accuracy rate was the lowest for this group, coming to 16% when mammography was combined with clinical examination, and only 8% when mammograms alone were read. Approximately 20% of all non‐malignant conditions were incorrectly interpreted as carcinoma from mammograms. Mammography is found to be a useful procedure in the detection of cancer of the breast in Asian women. Unpublished data from the Singapore Cancer Registry shows that cancer of the breast is the commonest malignant tumour in the female. It is therefore anticipated that mammography will be increasingly employed in the developing countries of South‐East Asia in the years to come.

Calcified carcinoma of the colon superimposed on chronic ulcerative colitis.

A case of calcified colonic carcinoma superimposed on ulcerative colitis is reported. Only 10 cases of colonic carcinoma with radiographically visible calcification have been reported previously in the English-language literature. None of these has been associated with ulcerative colitis. Histologically, all of the previously reported cases have been mucoid adenocarcinoma.

THE SOLITARY CIRCUMSCRIBED BRONCHOGENIC CARCINOMA. A RADIOLOGICAL STUDY OF 100 CASES.

The Solitary Circumscribed Bronchogenic Carcinoma. A Radiological Study of 100 CasesEric M. BatesonEric M. BatesonThe United Sheffield Hospitals*Present address: X-ray Dept., University College Hospital, Mona, Kingston, Jamaica.Search for more papers by this authorPublished Online:29 May 2014https://doi.org/10.1259/0007-1285-37-440-598SectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail AboutAbstractAn analysis of 100 solitary, circumscribed, bronchogenic carcinomas has been carried out with correlation of their radiological features with their histological type, clinical features and prognosis. Previous article Next article FiguresReferencesRelatedDetailsCited byRespiratory tractRespiratory TractEVALUATION AND MANAGEMENT OF SOLITARY AND MULTIPLE PULMONARY NODULESClinics in Chest Medicine, Vol. 13, No. 1The Solitary Pulmonary NoduleA calcified carcinoma of the lung and intracerebral metastasisJournal of Computed Tomography, Vol. 11, No. 4Evaluation of Pulmonary and Mediastinal MassesMedical Clinics of North America, Vol. 68, No. 6The Solitary Pulmonary NoduleRadiologic Clinics of North America, Vol. 21, No. 4Gutartige Primärtumoren der Bronchien und LungenSurvival rates in peripheral bronchogenic carcinomas up to four centimeters in diameter presenting as solitary pulmonary nodulesThe Journal of Thoracic and Cardiovascular Surgery, Vol. 57, No. 1Radiology of the aspergillomaClinical Radiology, Vol. 18, No. 4 Volume 37, Issue 440August 1964Pages: 565-644 © The British Institute of Radiology History ReceivedOctober 01,1963Published onlineMay 29,2014 Metrics Download PDF

Calcification in carcinoma of the colon

Summary 1. A case of calcification in a mucoid adenocarcinoma of the colon has been described. 2. Calcification in carcinomata of the gastrointestinal tract is rare. To date 13 cases have been reported and they have all shown evidence of mucoid degeneration. 3. Previous authors have suggested that the pattern of the calcification in these cases may be diagnostic. The present case did not conform to the previous descriptions.

Calcification in carcinoma of the stomach.

Calcification in carcinoma of the stomach.

Calcification in Carcinoma of the Stomach

Calcification in Carcinoma of the Stomach

Calcification in carcinoma of the rectum

The first case of calcification in carcinoma of the rectum is reported. The relation to five reported cases of ossification in carcinoma of rectum and colon is discussed. The significant factor in this case appears to be that the primary tumour grew throughout 38 weeks of pregnancy. In a large recurrence which developed after pregnancy was completed there was no evidence of calcification.

Roentgenographic diagnosis of calcification in carcinoma of the breast.

Abnormal calcification of tissue has attracted study from the earliest days of roentgenology, but, so far, calcifying processes in the breast have received little attention. Not until 1949 did an observation appear dealing with the diagnostic importance of punctate calcification in carcinoma of the breast. The significance of this report by Leborgne 1 has become evident to us after comparative x-ray and histological examination of the breasts of 425 patients. The use of the whole breast slicer technique of Ingleby 2 and of routine histological examinations have served to check accurately the roentgenographic findings, which are now based on recently improved techniques. 3 We suspect that we may have overlooked many cases of carcinomatous calcification in the films made by older techniques. The present method of examination, patterned after that of Leborgne, 1 takes advantage of fine grain, non-screen films and the small focal spot of the latest model, rotating