Cable barriers are one type of road restraint system commonly used on highways across the United States to contain and redirect errant vehicles and to prevent crossover accidents. These systems are typically tested under the provisions from safety manuals considering standard crash conditions (e.g., vehicle speed and impact angle). However, it is desirable to evaluate the effects of non-standard crash conditions, including different vehicle speeds, impact angles, foundation material stiffness, and cable pretension loads, to understand the performance of cable barriers. For that purpose, we created a set of full-scale finite element models in LS-DYNA to assess the effects of non-standard crash conditions on the performance of high-tension cable barrier systems. The results from the models showed that soft soils and under-tensioned systems yield higher transverse vehicle displacements. Moreover, the results indicated that speeding vehicles colliding at non-standard angles increase cable tensions by up to 91% while the transverse deformation increases by 318%. These findings highlight the importance of evaluating cable barrier performance under more severe scenarios outside of traditional standard configurations, which can lead to system failure and more severe collision consequences.