“Innovate or die!” is an often-heard statement indicating the urgent need for companies to engage in innovation to survive and grow in a sustainable way (Vanhaverbeke, 2017). The main objective of the project is to develop the education at theme of small and medium entrepreneurs (SMEs) in Visegrad countries (V4). The expected results are strengthening the abilities and competencies of students to launch start-up businesses in V4 regions, stimulating cross-border entrepreneurship cooperation in the V4 region, and building up new business networks for SMEs, start-ups, and research institutions within and outside V4. The primary objective of the project is strengthening the joint mutual representation of the V4 economies through educational development. Based on the tradition of important relations between the members in several fields of economy, the cooperation should be extended with learning of other countries’ economic, social, and cultural dimensions. Participating students will be able to launch new SME businesses within V4. The objective project goal is to strengthen the cooperation among the participating universities’ students in the field of profound understanding of different cultural, technological, and regional economic policies. In terms of coordinated and integrated educational programs, the projects strengthen professional networks of partner universities and support the mobility of students, researchers, and educators to share best practices in the education of business management. The common training and research program includes themes, such as SME-s in general, the profile of the SME sector, main Characteristics of the SME Sector, SME-s in V4, managing SMS-s, understanding environment, macro-economy, regulation, SME finance, strategy, analysis of competencies, strategic planning, project management, operational planning of SME, inventory management, selling activity for SME’s, human resources, performance measurement, staff management and legal environments to launch new business.