The article systematizes theoretical approaches to the concept of “ecosystem”, including business ecosystem, economic ecosystem, innovation ecosystem, entrepreneurial ecosystem, industrial ecosystem. The article also considers the prerequisites and retrospective evolution of the transition to the work format according to the principle of ecosystems when companies build their business models. The authors proposed the definition of the ecosystem of innovative development of the industrial sector as a set of interacting business entities (real sector, business), authorities, public organizations, scientific and educational organizations, which realize the implementation of joint functional tasks based on the joint use of the resource potential of all participants (actors) in order to achieve a synergistic effect. The component composition of the ecosystem of innovative development of enterprises is proposed. Differentiation of the benefits of the participants from the application of the ecosystem approach (economic, social, institutional, infrastructural) is provided. The concept of the innovation ecosystem was studied for the analysis of dynamic open environments, which include organizations, individuals and institutions that interact in the formation, use and dissemination of innovations. The key components of innovative ecosystems are defined and their interaction is highlighted. The importance of using information and digital platforms to optimize business processes in the ecosystem is emphasized. The characteristics that are typical for innovation ecosystems and modern innovation processes are highlighted. An algorithm for the introduction of an ecosystem approach to the model of innovative development of the industrial sector has been developed. Significant attention is paid to defining the differences between digital ecosystems and traditional business alliances. The risks arising during the transition of work to this business format, as well as prospects, are considered in detail development and society’s readiness to work in ecosystems on the basis of accumulated customer service experience.