Burst Strength Research Articles

Worldwide productivity and research trend of publications concerning SIAD: a bibliometric study.

Syndrome of inappropriate antidiuretic(SIAD) occurs secondary to various diseases, which is characterised by hypotonic hyponatremia and impaired urinary diluting capacity. Research on SIAD in both domestic and international contexts has a long history. This study objectively and comprehensively analyses the research trends, hotspots and development of SIAD research of the past 20 years using the method of bibliometric analysis. The 2003-2022 data in the Web of Science Core Collection database were searched. The Bibliometrix software package, VOSviewer and CiteSpace were used to mine, extract and visualise the retrieved literature, and the generated maps were used in analysing the main topics and trends in the field of SIAD research. A total of 1215 articles published in 623 journals were included in the analysis, with a total of 18,886 citations. Results showed that the research output on SIAD has continuously increased in the past 20 years, and the United States had the highest number of publications and citations. Keywords with the highest burst strength in recent years were the most mentioned keywords, in addition to the search terms 'hyponatremia', 'covid-19', and 'mortality'. Thus, the relationship among SIAD, covid-19 and mortality may become research frontiers and trends. Fifteen milestone articles were identified through co-citation analysis, which mainly focused on the pathophysiology and treatment of SIAD. Based on bibliometric analysis and knowledge mapping, this study summarises development trends in the field of SIAD research, providing references for current and future research into SIAD.

Development and characterization of pearl millet (AHB 1200) starch nanoparticle‐based edible films: A paradigm shift in food packaging

AbstractPearl millet, known for its adaptability to challenging agro‐climatic conditions, emerges as a valuable candidate for biopolymer‐based packaging. The AHB 1200 cultivar, distinguished by its high starch content, provides a reliable source for biopolymer extraction. The conversion of pearl millet starch into nanoparticles by acid hydrolysis represents a cutting‐edge method to enhance biopolymeric materials. The inclusion of these nanoparticle concentrations (0.5%, 1%, 5%, and 10%) into the film results in improved mechanical characteristics, reduced water permeability, and increased biodegradability. Furthermore, the lowered water solubility and reduced water vapor transmission rate (WVTR) further underscore their positive contributions. This study comprehensively examines various film properties, encompassing WVTR from 7.23 ± 0.06 to 4.57 ± 0.08 g/m2/s, moisture content, solubility from 35.29 ± 0.51% to 30.09 ± 0.15%, burst strength from 1102.11 ± 0.99 g to 1535.71 ± 0.63 g, thermal stability, and biodegradability from 65.16% to 92.89%. The findings highlight the notable advancements achieved through the integration of starch nanoparticles.Practical applicationsPearl millet (AHB 1200) starch nanoparticle‐based edible films offer a versatile solution for specialized food packaging needs because of their compatibility with various food types, dairy products, fresh produce, and so on. These films act as a protective barrier and maintain product freshness during storage and transit. It also has enhanced mechanical strength and tear resistance and provides vacuum‐sealed packaging, ensuring an extended shelf life. Beyond their functional benefits, these edible films present an opportunity for branding and marketing differentiation. The films made with pearl millet have an earthy, natural appearance that fits with today's customer inclination for sustainable and environmentally friendly goods. This allows manufacturers to leverage the films as a means of conveying their commitment to environmentally friendly practices, enhancing their brand image and consumer loyalty. Furthermore, the biodegradability of these films is preferred over plastic waste. They offer a viable alternative to traditional plastic packaging, aligning with global initiatives to reduce the environmental impact of packaging materials.

Characterization of biodegradable bi‐layer films from thermoplastic starch and poly‐l‐lactic acid

AbstractThis study aimed to enhance the oxygen barrier properties of polylactic acid (PLA) film, a biodegradable packaging material with high oxygen permeability (OP). Bi‐layer films were produced by coating thermoplastic starch (TPS) onto PLA films in various ratios while maintaining constant film thickness. The mechanical, optical, barrier, thermal, hydrophobicity, moisture sorption, and microstructural properties of the films were analyzed. Increasing the TPS ratio elevated moisture content (MC), water uptake, solubility, and opacity while enhancing UV barrier properties. TPS coating reduced tensile and burst strength but increased the burst deformation of the bi‐layer films. Bi‐layer film production resulted in a water vapor permeability increase of 59.26%–94.44% compared with neat PLA while decreasing OP by 2.52%–29.66%. The equilibrium moisture content (EMC) rose with higher TPS ratios, displaying type II isotherms. FTIR analysis indicated no chemical interactions between PLA and TPS. Increasing the TPS ratio decreased PLA crystallinity, supporting the mechanical and barrier properties of the bi‐layer films. Neat and bi‐layer films exhibited smooth, homogeneous surfaces, with a visible interface in the cross‐section of the bi‐layer films. In conclusion, TPS shows promise as an alternative to improve oxygen barrier properties in PLA films without adversely affecting other properties.

Deep eutectic solvent as plasticizing agent for the zein based films

This study explores, the impacts of incorporating of deep eutectic solvent (DES) as plasticizer on the characteristics of zein films. Investigation focused on examining the mechanical, thermal, surface, and microstructural properties of zein films that were plasticized using DES. The findings of the study revealed that by adding DES to zein films, there was an observed improvement in transparency. Additionally, it was observed that up to a 20% addition of DES led to a reduction in water vapor permeability (WVP). However, beyond this level, the WVP increased as the surface hydrophobicity decreased. The films that were plasticized with DES showed higher tensile and burst strength values than control. However, there was a decrease in the elongation at break and burst distance, except for the film containing 30% DES. The addition of DES as plasticizer resulted in smoother surface morphology compared to the control, and all films revealed homogeneous and non-porous surface and cross-section microstructure. The films plasticized with DES displayed three different thermal degradation temperatures resulting in higher thermal stability. The FT-IR spectrum of films showed similar backbone structure including Amide I, II and III bands. However, 5% DES plasticized film showed different secondary structural peaks of Amide I band due to lower α-helix and higher β-sheet and random coil content. The findings of this investigation indicate that the employment of DES as plasticizer in biodegradable polymer films can yield enhanced mechanical and barrier characteristics compared to conventional plasticizers, thus demonstrating its potential for effective use.

Sustainable paper-based packaging from hemp hurd fiber: A potential material for thermoformed molded fiber packaging

Hemp hurd fiber, a low-value waste stream from the hemp industry, has potential downstream applications as an alternative to non-renewable plastics for single-use food service ware and packaging applications. Packaging paper substrates made from chemically pulped hemp hurd, mixed in varying ratios with bleached thermomechanical radiata pine pulp were developed and tested. Handsheets were characterized using several mechanical property tests including tensile strength, tearing resistance, burst strength, short-span compression, ring crush, together with Gurley air resistance, contact angle, and Cobb60 tests. Generally, addition of hemp hurd fibers significantly improved handsheet mechanical properties. Hot-pressing of the handsheets so as to approximate molded fiber thermoforming further enhanced their performance, with pure hemp hurd handsheets having the highest mechanical properties and barrier performance. A prototype was successfully thermoformed from hemp fiber, demonstrating overall feasibility of this fibre source for molded fibre objects.

Multifunctional Wound Curation Dressing Material FemuFrost─An Antioxidant-Loaded Nanoemulsion Frosted Patch of Poly(vinyl alcohol) and Hyaluronic Acid.

The wound curation dressing material should own explicit elements to aggrandize wound cessation. The cryogel of poly(vinyl alcohol) (PVA) and hyaluronic acid (HA) is deemed to promote the angiogenesis, production of extracellular matrix components, granulation, and epithelialization. The research aims to tailor and evaluate the composite PVA/HA cryogel ingrained ferulic acid-loaded nanoemulsion patch labeled as PH-FemuFrost to improve the therapeutic properties and mechanical strength of the patches. The PH-FemuFrost exhibited a water uptake capacity of 268 ± 15.07%, porosity of 70.52 ± 7.4%, and 48.62 ± 2.2% in vitro degradation. The texture analysis revealed the improved mechanical properties of PH-FemuFrost in terms of burst strength and stiffness. The PH-FemuFrost exhibited in vitro antioxidant and antimicrobial activity against Staphylococcus aureus and Candida albicans species. The wound healing efficiency of PH-FemuFrost patches was significantly increased than blank PVA-HA patches. The groups treated with PH-FemuFrost exhibited a dense network of collagen type 1 in comparison to negative and PVA-HA groups. The normal skin and healed skin exhibited parallel arrangement of type I collagen fibers toward the skin. The levels of inflammatory mediators such as IL-6 (p value < 0.0001), IL-22 (p value 0.0098), and TNF-α levels (p value < 0.0001) of PH-FemuFrost is significantly reduced compared to the negative group.

Asymmetric adhesive SIS-based wound dressings for therapeutically targeting wound repair

Severe tissue injuries pose a significant risk to human health. Conventional wound dressings fall short in achieving effective tissue regeneration, resulting in suboptimal postoperative healing outcomes. In this study, an asymmetric adhesive wound dressing (marked as SIS/PAA/LAP) was developed, originating from acrylate acid (AA) solution with laponite (LAP) nanoparticles polymerization and photo-crosslinked on the decellularized extracellular matrix small intestinal submucosa (SIS) patch. Extensive studies demonstrated that the SIS/PAA/LAP exhibited higher tissue adhesion strength (~ 33 kPa) and burst strength (~ 22 kPa) compared to conventional wound dressings like Tegaderm and tissue adhesive products. Importantly, it maintained favorable cell viability and demonstrated robust angiogenic capacity. In animal models of full-thickness skin injuries in rats and skin injuries in Bama miniature pigs, the SIS/PAA/LAP could be precisely applied to wound sites. By accelerating the formation of tissue vascularization, it displayed superior tissue repair outcomes. This asymmetrically adhesive SIS-based patch would hold promising applications in the field of wound dressings.

Sodium Carbonate Pulping of Wheat Straw—An Alternative Fiber Source for Various Paper Applications

European paper mills are currently facing the question of whether recovered paper, their main raw material, will be available in sufficient quantities and an acceptable quality in the future. An alternative to recovered paper or wood fiber is the use of agricultural residues such as wheat straw. Sodium carbonate-based straw pulping processes have the advantage of not requiring recausticizing for chemical recovery, which reduces investment and operating costs. With the addition of oxygen, delignification can be significantly improved to provide pulps suitable for bleaching. This study compares the pulping of wheat straw using sodium carbonate, sodium carbonate + oxygen, and sodium carbonate + sodium hydroxide + oxygen. Pulping parameters such as temperature, retention time, and chemical charge were varied, and their influence on pulp properties was studied. The use of sodium carbonate alone produced pulps with high yields of up to 72% and comparably high burst and compressive strength. The addition of oxygen and small amounts of sodium hydroxide produced pulps with a high initial brightness of 42 %ISO and a low kappa number (18), still at high pulp yields of 62%. These pulps were two-stage bleached to achieve brightness levels of up to 73 %ISO.

Optimization of Electrospun Bilayer Vascular Grafts through Assessment of the Mechanical Properties of Monolayers.

Small-diameter vascular grafts must be obtained with the most appropriate materials and design selection to harmoniously display a variety of features, including adequate tensile strength, compliance, burst strength, biocompatibility, and biodegradability against challenging physiological and hemodynamic conditions. In this study, monolayer vascular grafts with randomly distributed or radially oriented fibers are produced using neat, blended, and copolymer forms of polycaprolactone (PCL) and poly(lactic acid) (PLA) via the electrospinning technique. The blending ratio is varied by increasing 10 in the range of 50-100%. Bilayer graft designs are realized by determining the layers with a random fiber distribution for the inner layer and radial fiber orientation for the outer layer. SEM analysis, wall thickness and fiber diameter measurements, tensile strength, elongation, burst strength, and compliance tests are done for both mono- and bilayer scaffolds. The findings revealed that the scaffolds made of neat PCL show more flexibility than the neat PLA samples, which possess higher tensile strength values than neat PCL scaffolds. Also, in blended samples, the tensile strength values do not show a significant improvement, whereas the elongation values are enhanced in tubular samples, depending on the blending ratio. Also, neat poly(l-lactide-co-caprolactone) (PLCL) samples have both higher elongation and strength values than neat and blended scaffolds, with some exceptions. The blended specimens comprising a combination of PCL and PLA, with blending ratios of 80/20 and 70/30, exhibited the most elevated burst pressures. Conversely, the PLCL scaffolds demonstrated superior compliance levels. These findings suggest that the blending approach and fiber orientation offer enhanced burst strength, while copolymer utilization in PLCL scaffolds without fiber alignment enhances their compliance properties. Thus, it is evident that using a copolymer instead of blending PCL and PLA and combining the PLCL layer with PCL and PLA monolayers in bilayer vascular graft design is promising in terms of mechanical and biological properties.

Worldwide research trends on tumor burden and immunotherapy: a bibliometric analysis.

Various immunotherapy has been greatly applied to comprehensive treatment of malignant cancer under different degrees of tumor burden. Scientific researchers have gained considerable progress in the relationship between immunotherapy and tumor burden in recent years. This review aimed to explore the prospect and developing trends in the field of tumor burden and immunotherapy from a bibliometric perspective. Articles about tumor burden and immunotherapy were collected from the Web of Science Core Collection (WoSCC) (retrieved on 3 January 2023). The R package 'Bibliometrix' analyzed the primary bibliometric features and created a three-filed plot to display the relationship between institutions, countries, and keywords. VOSviewer was used for co-authorship analysis, co-occurrence analysis, and their visualization. And CiteSpace calculated the citation burst references and keywords. A total of 1030 publications were retrieved from 35 years of scientific researches. The United States (US) and China published the most articles. The most productive journals were Cancer Immunology Immunotherapy and Journal for ImmunoTherapy of Cancer . The top one institution of the highest output was University of Texas MD Anderson Cancer Center. The hot keywords of strong citation burst strength in recent years were 'nivolumab', 'tumor microenvironment', and 'immune checkpoint inhibitor'. The most popular tumor type is melanoma. This bibliometric analysis mapped a basic knowledge structure. The field of tumor burden and immunotherapy is entering a rapid growing stage and keeping it value for future research.

Influence of Electrospinning Parameters on the Morphology of Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Fibrous Membranes and Their Application as Potential Air Filtration Materials.

A large number of non-degradable materials have severely damaged the ecological environment. Now, people are increasingly pursuing the use of environmentally friendly materials to replace traditional chemical materials. Polyhydroxyalkonates (PHAs) are receiving increasing attention because of the unique biodegradability and biocompatibility they offer. However, the applications of PHAs are still limited due to high production costs and insufficient study. This project examines the optimal electrospinning parameters for the production of PHA-based fibrous membranes for air filtration. A common biodegradable polyester, Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), was electrospun into a nanofibrous membrane with a well-controlled surface microstructure. In order to produce smooth, bead-free fibers with micron-scale diameters, the effect of the process parameters (applied electric field, solution flow rate, inner diameter of hollow needle, and polymer concentration) on the electrospun fiber microstructure was optimized. The well-defined fibrous structure was optimized at an applied electric field of 20 kV, flow rate of 0.5 mL/h, solution concentration of 12 wt.%, and needle inner diameter of 0.21 mm. The morphology of the electrospun PHBV fibrous membrane was observed by scanning electron microscopy (SEM). Fourier transform infrared (FTIR) and Raman spectroscopy were used to explore the chemical signatures and phases of the electrospun PHBV nanofiber. The ball burst strength (BBS) was measured to assess the mechanical strength of the membrane. The small pore size of the nanofiber membranes ensured they had good application prospects in the field of air filtration. The particle filtration efficiency (PFE) of the optimized electrospun PHBV fibrous membrane was above 98% at standard atmospheric pressure.

Study on the Burst Failure Mechanism and Residual Strength of Casing With Compound Wear Based on Extended Finite Element Method

Abstract Based on the data of wear casing for ShunNan 501 well in Northwest oilfield and the stress–strain intrinsic relationship of P110 tubing, a two-dimensional mechanical model of casing with compound wear is established by using the nonlinear extended finite element method (XFEM) and the burst failure criterion of damage evolution with due consideration of wear type, angle between crescents, overlap depth of crescents, and wear depth caused by drill pipe body and tool joint. The accuracy and reliability of model are verified by the full-scale burst test data. The effects of wear types, angle between crescents, overlap depth of crescents, and wear depth on the internal pressure yield strength (IPYS), burst strength and failure behavior for casing with compound wear are analyzed, by which it is found that casing with compound wear exist stress interference and complex interaction between stress interference and stress concentration, and the burst failure mechanism of casing with compound wear is revealed. Based on the gray correlation analysis result of wear parameters, a prediction model of the residual strength for P110 casing with compound wear is established by 1stOpt software and universal global optimization (UGO) algorithm.

Development of multifunctional sustainable packaging from acetylated cellulose micro-nanofibrils (CMNF)

Cellulose micro-nanofibrils (CMNF) with different fibrillation levels were partially acetylated while preserving their morphological and native crystalline structure. The morphological changes due to fibrillation and chemical modification were observed using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and optical profilometry. The change in tensile and burst strength, barrier, and biodegradability profile were investigated which revealed that the mechanical properties of the unmodified CMNF films increased with increase in extent of fibrillation. However, the mechanical strength of the acetylated film decreased with the increase in degree of acetylation. The stretching or folding property of the film increased with the increase in both the fibrillation and acetylation. The contact angle value increased due to a higher degree of fibrillation and acetylation because they increased the hydrophobicity and consequently enhanced the air and water vapor resistance of the unmodified and modified CNF films. Furthermore, all films exhibited the highest resistance against oil and grease, and the biodegradability test substantiated that CNF films were compostable in soil. In total, this work expresses new pathways to enhance the barrier properties of biodegradable CNF films by regulating the degree of fibrillation and acetylation, thus can emerge as sustainable alternatives for packaging and agriculture applications.

Production of filter material from various natural fibers

In this study, a composite filter paper was fabricated using cellulose derived from Flax and cotton linters, along with the incorporation of basalt fiber. The aim was to develop a filter paper with enhanced filtration performance and mechanical strength.The composition and properties of the mineral filler employed in the preparation of the filter paper were thoroughly investigated. The mineral filler, which played a crucial role in influencing the properties of the composite, was carefully selected and characterized. Its particle size, surface area, and chemical composition were analyzed to understand its impact on the filtration efficiency and mechanical integrity of the filter paper.To evaluate the performance of the composite filter paper, comprehensive testing methods were employed. The filtration efficiency, pressure drop across the filter, and mechanical strength properties such as tensile strength and burst strength were assessed. These tests provided quantitative data to determine the effectiveness of the composite filter paper in capturing particles of varying sizes and its structural stability during the experimental investigation were presented in graphical form to provide a clear visual representation of the data. These graphs allowed for easy interpretation and comparison of the properties and performance of the composite filter paper under different conditions.

A Bibliometric Review of Maturity Model Studies in the Construction Industry

Maturity models have become one of the most used organisational maturity assessment tools in the construction industry. However, bibliometric and visual analysis for this field is still scarce. This study used CiteSpace to analyse 278 articles on maturity models employed in the construction industry from 2000 to 2022 in the Web of Science (WoS) core database. The categories in the WoS database divided the filtered articles into eight categories, which could be roughly divided into three fields: (1) Construction and Engineering, (2) Green Sustainability and Environment, and (3) Integrated Management. The keyword cooccurrence analysis based on frequency, centrality and burst strength revealed that “Building information modelling (BIM)”, “System” and “Impact” were relatively significant terms. This finding indicated that maturity models are a systematic assessment tool often used in the BIM domain. The analysis of the evolution of keywords also revealed that maturity-related research could be divided into five stages and that the application of maturity models at each stage focused on different areas within the construction industry. The analyses of the current review direct future research to focus more on the integration of green sustainability with other topics, explore new technologies, investigate the applicability of maturity theories and validation studies and conduct more action-oriented guided research. The results of this study guide researchers to utilise maturity models in the effort to systematically understand current research efforts and future trends of the tool in the construction industry, as well as provide references for managers of building construction companies and government personnel who develop policies for the construction industry.

Knowledge structure and global trends of machine learning in stroke over the past decade: A scientometric analysis

ObjectiveMachine learning (ML) models have been widely applied in stroke prediction, diagnosis, treatment, and prognosis assessment. We aimed to conduct a comprehensive scientometrics analysis of studies related to ML in stroke and reveal its current status, knowledge structure, and global trends. MethodsAll documents related to ML in stroke were retrieved from the Web of Science database on March 15, 2023. We refined the documents by including only original articles and reviews in the English language. The literature published over the past decade was imported into scientometrics software for influence detection and collaborative network analysis. Results2389 related publications were included. The annual publication outputs demonstrated explosive growth, with an average growth rate of 63.99 %. Among the 90 countries/regions involved, the United States (729 articles) and China (636 articles) were the most productive countries. Frontiers in Neurology was the most prolific journal with 94 articles. 234 highly cited articles, each with more than 31 citations, were detected. Keyword analysis revealed a total of 5333 keywords, with a predominant focus on the application of ML models in the early diagnosis, classification, and prediction of “acute ischemic stroke” and “atrial fibrillation-related stroke”. The keyword “classification” had the first and longest burst, spanning from 2013 to 2018. ‘Upport vector machine’ got the strongest burst strength with 6.2. Keywords such as ‘mechanical thrombectomy’, ‘expression’, and 'prognosis' experienced bursts in 2022 and have continued to be prominent. ConclusionThe applications of ML in stroke are increasingly diverse and extensive, with researchers showing growing interest over the past decade. However, the clinical application of ML in stroke is still in its early stages, and several limitations and challenges need to be addressed for its widespread adoption in clinical practice.

Mapping the landscape of PSC-CM research through bibliometric analysis.

The discovery of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) has not only deepened our understanding of the pathogenesis and progression of heart disease, but also advanced the development of engineered cardiac tissues, cardiac regenerative therapy, drug discovery and the cardiotoxicity assessment of drugs. This study aims to visualize the developmental trajectory of PSC-CM research over the past 18 years to identify the emerging research frontiers and challenges. The literature on PSC-CMs from 2007 to 2024 was retrieved from the Web of Science and PubMed databases. Bibliometrix, VOSviewer and CiteSpace software were used for statistical analysis and visualization of scientific literature. Previous clinical trials were summarized using data from the ClinicalTrials.gov database. A total of 29,660 authors from 81 countries and regions published 6,406 papers on PSC-CMs over the past 18 years. The annual output of PSC-CM research experienced a general upward trend from 2007 to 2021, reaching its peak in 2021, followed by a notable decline in 2022 and 2023. The United States has emerged as the most influential nation in this field, with Stanford University being the most prolific institution and Joseph C. Wu standing out as the most productive and highly cited scholar. Circulation Research, Circulation, and Nature have been identified as the most co-cited journals. Organ-on-a-chip, 3D bio-printing, cardiac microtissue, extracellular vesicle, inflammation, energy metabolism, atrial fibrillation, personalized medicine etc., with a longer burst period, and maturation of PSC-CMs, with the highest burst strength of 27.19, are the major research focuses for rigorous investigation in recent years. Cardiac organoid is emerging as a promising key research frontier. While the clinical trials of stem-cell-mediated treatment for heart diseases shows promise, significant challenges remain. Further research is imperative to optimize protocols, enhance cell delivery methods, and establish standardized practices to improve clinical outcomes. In conclusion, several major research hotspots, including engineered cardiac tissue and maturation, exosome-based regenerative therapy, inflammation response, energy metabolism, atrial fibrillation, and personalized medicine etc. will continue to attract substantial interest from investigators worldwide. Cardiac organoids to in vitro recapitulate the intricate human heart is emerging as a promising key research frontier. Significant challenges persist in the clinical trials of stem-cell-mediated therapies for heart diseases.

Hotspots and Trends in Meningioma Research Based on Bibliometrics, 2011–2021

Meningiomas, the most prevalent benign intracranial neoplasms, have been studied extensively for many years, but significant problems remain. To date, there is a scarcity of detailed studies elucidating the hotspots and future directions of meningiomas research. A comprehensive search and screening strategy was used to collect relevant studies published between 2011 and 2021 in the Web of Science Core Collection database. Thorough and systematic coauthorship and co-occurrence keyword maps were generated, and tables of statistics summarizing countries, organizations, authors, and keywords were created. A total of 1544 articles meeting the screening criteria were collected. The countries producing the most publications between 2011 and 2021 were the United States, Germany, and China, with 586, 244, and 197 records, repectively. The cooperation networks also revolved mainly around these 3 countries, particularly the United States. The most frequently used keyword was "surgery," followed by "recurrence" and "management," with the frequencies of 248, 212, and 163, respectively. The most prominent cluster during the last decade was the #0 methylation cluster, and several keywords, including "survival," "brain invasion," and "magnetic resonance imaging," exhibited significant burst strength. This study aimed to provide a comprehensive analysis of the research landscape and to identify potential research directions. Our findings disclose productive individuals and institutions. The current research focuses on the molecular pathology of meningiomas, improvements in techniques, and advances in diagnosis by magnetic resonance imaging. In particular, the improvements in molecular pathology might direct future research directions.

Freeze Drying and Vial Breakage: Misconceptions, Root Causes and Mitigation Strategies for the Pharmaceutical Industry

Vial breakage during or following freeze drying (lyophilization) is a well-known and documented phenomenon in the pharmaceutical industry. However, the underlying mechanism and probable root causes are not well characterized. Mostly, the phenomenon is attributed to the presence of crystallizing excipients, such as mannitol in the formulation, while other potential factors are often underestimated or not well studied. In this work we document a systematic multipronged approach to characterize and identify potential root cause(s) of vial breakage during lyophilization. Factors associated with formulation, product configuration, primary container and production process stress conditions were identified and their impact on vial breakage was studied in both lab and manufacturing scale conditions. Studies included: 1) strain gauge and lyophilization analysis for stress on glass vials with different formulation conditions and fill volumes, 2) manufacturing fill-finish process risk assessment (ex. loading and frictive force impact on the vials), and 3) glass vial design and ruggedness (ex. glass compression resistance or burst strength testing). Importantly, no single factor could be independently related to the extent of vial breakage observed during production. However, a combination of formulation, fill volume, and vial weakening processes encountered during at-scale production, such as vial handling, shelf loading and unloading, were identified to be the most probable root causes for the low levels of vial breakage observed. The work sheds light on an often-encountered problem in the pharmaceutical industry and the results presented in this paper argue against the simplistic root-cause explanations reported in literature. The work also provides insight into the possibility of implementing mitigative approaches to minimize or eliminate vial breakage associated with lyophilized drug products.

Application of medical imaging in ovarian cancer: a bibliometric analysis from 2000 to 2022.

Ovarian cancer (OC) is the most lethal tumor within the female reproductive system. Medical imaging plays a significant role in diagnosis and monitoring OC. This study aims to use bibliometric analysis to explore the current research hotspots and collaborative networks in the application of medical imaging in OC from 2000 to 2022. A systematica search for medical imaging in OC was conducted on the Web of Science Core Collection on August 9, 2023. All reviews and articles published from January 2000 to December 2022 were downloaded, and an analysis of countries, institutions, journals, keywords, and collaborative networks was perfomed using CiteSpace and VOSviewer. A total of 5,958 publications were obtained, demonstrating a clear upward trend in annual publications over the study peroid. The USA led in productivity with 1,373 publications, and Harvard University emerged as the most prominent institution with 202 publications. Timmerman D was the most prolific contributor with 100 publications, and Gynecological Oncology led in the number of publications with 296. The top three keywords were "ovarian cancer" (1,256), "ultrasound" (725), and "diagnosis" (712). In addition, "pelvic masses" had the highest burst strength (25.5), followed by "magnetic resonance imaging (MRI)" (21.47). Recent emergent keywords such as "apoptosis", "nanoparticles", "features", "accuracy", and "human epididymal protein 4 (HE 4)" reflect research trends in this field and may become research hotspots in the future. This study provides a comprehensive summary of the key contributions of OC imaging to field's development over the past 23 years. Presently, primary areas of OC imaging research include MRI, targeted therapy of OC, novel biomarker (HE 4), and artificial intelligence. These areas are expected to influence future research endeavors in this field.