Background: Occupational burnout is a type of prolonged response and has been regarded to be associated with chronic jobrelated stress and decreased job performance. Objectives: In this study, we aimed to determine the level of occupational burnout and its related factors among medical imaging workers across Bandar Abbas hospitals in Iran. Methods: A questionnaire-based study was conducted among employees of medical imaging departments across Bandar Abbas hospitals, and the Maslach Burnout Inventory (MBI) was used to determine the level of burnout. A total of 150 complete responses were analyzed using independent samples t-test, one-way analysis of variance, and Pearson’s correlation in SPSS version 20. Results: Medical imaging employees had amoderatemean score for all the subscales of burnout, namely emotional exhaustion (EE) (20.7 ± 9.57), depersonalization (DP) (5.46 ± 5) and personal accomplishment (PA) (33.77 ± 7.97), compared to MBI norms. There were significant differences in each of the MBI subscales based on age, work experience, marital status and type of work environment. Also, the correlation between EE and DP scores and gender, DP and PA scores and academic degree and EE and PA scores and work load were significant (P < 0.05). However, there was no significant interrelationship between DP and workload, PA and gender EE and academic degree. Conclusions: Demographic and occupational variables can affect the level of burnout. Occupational burnout, on the other hand, may influence the quality of care. Therefore, modifying the work status and respecting the experience and expertise of radiographers can reduce occupational burnout among medical imaging employees.