ObjectiveThe issue of burnout-depression overlap remains contentious. In this study, the question of whether burnout symptoms form a syndrome that is distinct from depression was reexamined. MethodsThe study involved 332 employed individuals (65% female; mean age: 34). Burnout symptoms were assessed with the Shirom-Melamed Burnout Measure (SMBM). The SMBM operationalizes burnout based on three interconnected components, namely, physical fatigue, cognitive weariness, and emotional exhaustion. Depressive symptoms were assessed with the PHQ-9, a scale that covers the main manifestations of major depression. Confirmatory factor analysis (CFA) and exploratory structural equation modeling (ESEM) bifactor analysis were conducted. ResultsOn average, the factors underlying burnout's components correlated more strongly with the Depressive Symptom factor than with each other. Remarkably, such results were obtained even when fatigue-related items were excluded from the depression scale. Second-order CFA revealed that the factors underlying burnout's components and the Depressive Symptom factor were reflective of the same higher-order factor. ESEM bifactor analysis indicated that the general factor accounted for about 2/3 of the common variance extracted. ConclusionConsistent with a growing corpus of research, this study suggests that the burnout-depression distinction is untenable. Because the burnout-depression distinction tends to convey the idea that burnout is not as serious a problem as depression, many people struggling with depression might underestimate the gravity of their condition and not seek help when self-identifying as “burned out.” Maintaining a line of demarcation between burnout and depression may thus be problematic from both a scientific and a health management standpoint.