Purpose: Case Report: A 38-year-old white female with past medical history of mental retardation, seizure disorder, hypothyroidism, and osteoporosis was admitted with complaints of apparent painful abdominal distention, fever and vomiting. Patient was on PEG tube feedings for several years. There was no history of alcohol use and medication list included levothyroxine, phenytoin, docusate sodium and calcium carbonate. The patient was febrile (T-103 F), hypotensive (87/49) and tachycardic (P-122). On examination, patient's abdomen was distented, mildly firm with decreased bowel sounds but no guarding or rigidity. Laboratory work-up showed H/H of 17.3/50.4, WBC count 27500, amylase and lipase of 1602 and 1903 respectively. The liver function test, serum triglyceride level, serum calcium level and IgG subclass 4 were normal. Ultrasound of the abdomen did not reveal any gallstone, sludge or biliary dilatation. A subsequent CT scan of the abdomen with oral and intra-venous contrast showed peri-pancreatic fat stranding suggestive of pancreatitis; the stomach was filled with fluid and the gastrostomy tube balloon was noted to be impacted in the second part of the duodenum. The PEG tube was pulled back then externally secured to allow drainage of fluid and air. Patient was managed with aggressive hydration, ventilatory support and antibiotics. Her clinical condition improved with amylase and lipase returning to normal. Discussion: PEG tube feeding is considered a safe, efficient and convenient method of long term enteral nutrition. It is generally associated with minor complications like abdominal pain, infection, leakage, buried bumper syndrome, gastrointestinal bleeding and ulceration. Acute pancreatitis is an extremely rare complication of gastrostomy tube insertion mainly due to migration and direct mechanical ampullary obstruction at the level of the second duodenum. To our knowledge, this is the third case of PEG-induced pancreatitis reported throughout the medical literature. It is important to recognize this life threatening complication in patients with PEG tube presenting with abdominal pain and vomiting.Figure 1: Computed tomography showing PEG tube and acute pancreatitis.