Objective To investigate family caregivers′ burden and fatigue condition of home-living patients with Parkinson′s disease and to explore the relationship between the burden of care and the condition of fatigue. Methods By convenience sampling methods, 136 family caregivers, who took care of Parkinson′s disease patients, were investigated. Caregiver burden scale and fatigue self rating scale were used to investigate the burden and fatigue status of primary caregivers of patients with Parkinson′s disease. Results The total score of home caregiver′s burden was (37.54±8.15) and the total score of fatigue was (53.18±11.62). The total score of the care burden was positively correlated with the total score of fatigue of primary caregivers of home Parkinson patients (P<0.05); personal burden and physical fatigue, mental fatigue, fatigue total score was positively correlated (P<0.05); the burden of responsibility and the decrease in the dynamics, mental fatigue was positively correlated (P<0.05). Conclusions The burden of family caregivers of home-living patients with Parkinson′s disease is moderate, and the fatigue condition is in the moderate level of fatigue. Nurses should strengthen the evaluation of the family caregivers′ burden of home-living patients with Parkinson′s disease, in order to relieve their fatigue status. Key words: Parkinson; Caregiver; Burden of care; Fatigue condition