This paper presents theoretical notions with practical applications for establishing the lifetime of a dental bur (durability and reliability) based on the wear of the active part and considering a series of statistical indicators. To justify applying theoretical notions in practice, a conical–cylindrical dental bur is studied experimentally to obtain a series of data of the work process necessary for statistical calculation. The parameter taken into consideration in this paper is mass lost through the wear of the dental bur active part, based on testing. This is useful for dental bur lifetime establishment and its extension or even optimization in operation. The loss of mass of the dental bur active part is analyzed in the work process using the results and experimental data obtained and validated by statistical–mathematical numerical calculation. The numerical calculation approximates the mass lost through wear at different rotation speeds and operation times, and based on a comparison with the experimentally determined ones, the lifetime was established. The results show that the dental bur works with high yield in the first 20 h of work, after which it should be replaced with a new one. Theoretically, the studied dental bur can work over 21 h. Practically, it can work up to 18 h without major risk of failure, but the lifetime can be extended up to 20 h, at which point the failure risk can reach 10% and it is recommended to replace the bur.