The fused silica is an important optical material in the large laser devices, which are often subject to laser induced damage in the laser systems. In this work we studied nanosecond laser induced damage in JGS1 fused silica at the three harmonic wavelengths of the 1064 nm, 355 nm and 248 nm. Under 1064nm/10ns, 355nm/10ns and 248nm/22.8ns laser irradiation, the bulk damage threshold is 150 J/cm2, 15 J/cm2 and 7 J/cm2, respectively. The results showed that the weakest point of bulk damage threshold among the three tested wavelengths is 248 nm. And the damage threshold decreases sharply with the decrease of wavelength.