Housing and its indoor environment influence its inhabitants’ comfort, productivity, and health. For this reason, it is becoming increasingly important to investigate the factors that affect indoor environmental quality. Thus, numerous sustainability assessment systems have been developed to evaluate building performance. This paper presents a model for evaluating the indoor environment of housing located in the Biobio region of Chile, integrating aspects that influence its overall quality. The research methodology proposes a strategy to identify appropriate evaluation criteria and contextualized standards. The application of the model made it possible to identify the level of performance of studio dwellings for each category, namely air quality, thermal comfort, acoustics, and lighting, as well as the overall evaluation of the IEQ. The results reflect that the lowest levels of performance in the three houses were with respect to the acoustic evaluation criteria, while the highest levels of performance were for the air quality evaluation criteria.