Passive design strategies (PDS) are a fitting solution to reduce the ever-growing energy cost of residential high-rise buildings in tropical regions. However, PDSs’ building energy saving potential significantly varies with local climate conditions, but it has been sparsely investigated. Hence, this study investigated the energy-saving efficiency of eight common PDSs integrated into a typical residential high-rise building in three sub-climates: extremely hot humid (0A), very hot humid (1A), and warm humid (3A) defined by ASHRAE for the tropical climate. This study developed a Building Performance Analysis (BPA) workflow with a BIM-based simulation framework and local and global sensitivity analyses for the building energy analysis. The global sensitivity analysis revealed that low e-coating on glasses is the most influential PDS for 0A and 1A climates, but it has a negative effect in the sub-climate zone 3A. The low-conducting exterior walls are the most effective PDS in the sub-climate zone 3A, but they are poorly performed in the other two sub-climate zones. Based on the energy calculation and sensitivity analysis, this study proposes the best PDS groups, saving up to 40.1%, 63.5%, and 31.7% of average annual building consumption in the sub-climate zones, 0A, 1A, and 3A climates.