Wind stability and design loads of long-span bridges are assessed applying experimental and theoretical methods. The commonly used approach entails the extraction of fundamental aerodynamic data of key structural elements such as the deck, towers, and cables, either experimentally or numerically, and the application of theoretical models for evaluation of structural responses to turbulent winds. This phenomenon called buffeting is extremely complex and, to date, there is no closed-form theoretical model to reproduce how the wind converts to structural responses and loads which the bridge must resist. The objective of this paper is to explore the base of the problem, namely the transformation of wind gusts to actual loads, and the response estimations. The time domain response approach has been adopted for solution of the generalized equations of motion allowing the exploration of details in the performance of various theoretical interpretations. Starting from the classic quasi-static linear model, theoretical simplifications are removed toward a more complete model of buffeting loads. Non-linear and aerodynamic coupling effects on response predictions are examined specifically aiming at improved buffeting load representations within the framework of the currently available experimental data. A new concept called stack state-space analysis has been introduced for the response solution to wind buffeting. Aerodynamic and structural data of Pierre-Laporte Bridge in Québec City, and the IABSE Working Group 10, long-span bridge validation example, are utilized as representative cases in this study. Avenues for further experimental and numerical validations of the presented new solution approach are suggested toward more accurate predictions of wind response and design loads of long-span bridges.