PURPOSES: 1) To examine spatial effects of green space on health outcomes at various levels of geography; 2) To examine the potential mediating effect of physical activity on the relationship between green space and health outcomes. METHODS: Socio-demographic (e.g., sex, race, poverty, age) and health outcome variables (e.g., obesity, diabetes, heart disease, and mental health) were derived from the 2010-2015 Illinois Behavioral Risk Factor Surveillance System (BRFSS). Measures of green-space were created using tree canopy data from the 2011 National Land Cover Dataset (NLCD). Residential area was defined using measures of urban density by counting dwellings per 10 hectares. Green space was calculated for three levels of buffers, specifically 300m, 500m, 1km for each residential unit and the entire county where the residential unit was located. ArcGIS 10.3 (ESRI, CA), was used to geoprocessing all data. Residential green space was used as the primary independent variable while accounting for socio-demographic variables in regression analysis. RESULTS: Due to missing data, only 78 of 102 Illinois counties (76.47 %) were included in the analysis. The amount of green space, regardless of buffer level, has no association with health outcomes. Physical activity explained a significant proportion of variance only for diabetes all measures of green space: 300m, 500m, and 1000m for residential units (β= -.12, p<.03; R2=.30, p<0.001); county level (β= -.14, p<.02; R2=.31, p<.001). CONCLUSIONS: Although county level green space was negatively associated with physical activity, residential green space showed no association. This difference supports the importance of appropriately defining geographical units used for large-scale population-based. Further studies clarifying geographic units of analysis are required.