Cold-Formed Steel (CFS) members are highly susceptible to several structural instability phenomena, involving either individual (Local — L, Distortional — D and Global — G) or interaction (LD, LG, DG, and LDG) buckling modes. The buckling mode interaction of CFS columns and beams may lead to strength erosion compared to isolated modes and must be considered in structural design. The North American, Australian/New Zealand and Brazilian standards incorporated the Direct Strength Method (DSM) that provides accurate design approach for columns and beams affected by L, D, G, and LG buckling modes. However, the coupled LD, DG, and LDG buckling modes are not currently considered in the DSM and many recent research projects have been focused on these topics. The procedure adopted by DSM estimates the CFS member strength through experimentally calibrated design strength equations and curves, based on the relationship between the member elastic stability and the steel yielding property, respectively the elastic critical buckling load and the plastic load, represented by the slenderness factor. The more accurate the buckling load, the more improved will be the result of the column strength by the DSM equations. In this context, the present paper presents the main results of the investigation, based on both experimental and finite element method numerical results, that conducted to calibrated strength curves for CFS unstiffened sections columns without holes covering LD interaction buckling mode. To take into account the effect of the LD buckling, the proposed procedure for design purposes incorporates the slenderness factor ratio RλDL=λD/λL as the main variable, and λL, λD, λG as the local, distortional and global slenderness factors, respectively.