Purpose: Case 1: 36-year-old man presented with 8 months of intermittent nausea, vomiting, epigastric pain and a 30-pound weight loss. EGD revealed a large, sessile lipoma-like mass in the duodenal bulb. EUS was not useful due to movement of the mass back and forth within the distal duodenum. The mass was injected with epinephrine and removed with a hot snare; Roth basket was used for retrieval. Two clips were placed at the resection site with no evidence of bleeding or perforation. Pathology revealed a Brunner's Gland hamartoma (BGH) that measured 2.6 cm in greatest dimension. Case 2: 59-year-old woman presented with a long history of intermittent epigastric pain, postprandial nausea and a 15-pound weight loss over several months. EGD with EUS revealed a 4 cm heterogeneous, pedunculated mass in the duodenal bulb arising from both deep mucosa and submucosa. The mass ball-valved into the antrum, intermittently obstructing the pylorus. The mass was injected with epinephrine and removed with a hot snare; Roth basket was used for retrieval. The site was clipped without complication. Pathology was diagnostic and revealed a BGH measuring 4 cm. Case 3: 43-year-old man presented with 7 months of reflux without nausea or vomiting and intermittent melena after treatment for H. pylori. He had a 40-pound weight gain. EGD/EUS revealed a lobulated, pedunculated polypoid mass in the apex of the duodenal bulb which originated from the submucosa. Ulceration was noted on the underside of the lipoma-like mass, and it was removed with a hot snare. A clip was placed for minimal oozing after resection. Pathology revealed a 3 cm BGH. Discussion: A number of reports describing the removal of BGH by endoscopy have been published. We report the second series of endoscopic resection of BGH with EUS. Brunner's Glands are in highest concentration in the duodenal bulb and secrete alkaline substances in response to acid. Adenomas arising from these glands are referred to as Brunner's Gland hamartoma, Brunner's Gland hyperplasia or Brunneroma. Larger lesions can cause abdominal pain, bleeding and intermittent obstruction with nausea, vomiting or bloating. Options for removal include surgical resection or endoscopic polypectomy. Biopsies taken during EGD are often normal because normal mucosa overlies the hyperplasia. More recently, EUS has been used to differentiate BGH from other similarly appearing tumors of the duodenum. Traditionally felt to require surgical resection, large Brunner's Gland hamartomas can be safely and effectively removed by endoscopic resection, particularly with the aid of EUS. Endoscopic removal should be considered as first-line therapy if technically possible.