A mathematical model is presented to analyze the magnetohydrodynamic (MHD) convective flow in a rectangular enclosure. Earlier studies on the Tiwai-Das volume fraction nanofluid model did not consider the Buongiorno nanofluid model. This is the focus of the present analysis which examines the laminar mixed convection magnetohydrodynamic flow of a nanofluid in a differentially heated rectangular enclosure with complex boundary conditions under an inclined magnetic field. Buongiorno's two-component nanofluid model is employed, which incorporates the effects of Brownian motion and thermophoretic diffusion of nanoparticles. Magnetic nanofluids have considerable potential for enhancing transport processes in energy systems such as hybrid fuel cells. The study is essential with heat generation/absorption effects. Additionally, the work is highlighted by the general case of an oblique (inclined) magnetic field. The conservation equations for mass, primary and secondary momentum, energy, and nanoparticle concentration with wall boundary conditions are dimensionless using appropriate scaling transformations. A finite-difference computational scheme known as the Harlow-Welch Marker and Cell (MAC) method is employed to solve the dimensionless nonlinear coupled boundary value problem. A mesh independence study is included. Graphical plots are presented for the impact of key control parameters on streamline contours, isotherm contours, iso-concentration (nanoparticle mass) contours, and local Nusselt number. With heat sink (absorption), the Nusselt number is enhanced in magnitude whereas it is suppressed with heat generation since there is a heat reduction transmitted to the boundary. The configurations of streamlines, isotherms, and iso-concentrations are mostly invariant to magnetic field direction changes. The obtained results show interesting behaviors of the flow and thermal fields, which mainly involve the effect of Brownian motion and thermophoresis parameters, as well as unsteady regimes, depending on specific values of the Schmidt number, Richardson number, and Prandtl numbers. Increasing the Schmidt number induces a contraction in the central cooler zone in the enclosure and also reduces the iso-concentration magnitudes in the central region across the enclosure. The core region of the enclosure heats up as the thermophoresis and Brownian motion parameters rise, pushing the previously cooler top and bottom wall zones further away from the center. There is also a decrease in iso-concentration magnitudes in particular at the upper and lower boundaries at higher values of Brownian motion and thermophoresis parameters. At decreasing buoyancy ratios, the left vortex cell first decelerates while the right vortex cell accelerates. However, when the buoyancy ratio increases, the left vortex cell streamlines magnitudes increase with a contraction in vortex size, while the right cell develops. A Very minor alteration is observed in the isotherm and iso-concentration contours with an increasing buoyancy ratio. When the Richardson number increases, the vortex cell structures shift from a strong circulation cell on the left to a weaker cell on the right, resulting in reverse distribution. With the rising Richardson number, significant cooling is also caused in the core zone, as well as a drop in iso-concentrations, with the original dual low-concentration upper and lower zones merging into a single center zone. The original symmetric left and right vortex cells are gradually twisted diagonally towards the right wall as the magnetic field increases, yet the stronger right cell and the weaker left cell are maintained.