Tridax procumbens is a well-known medicinal herb that has traditionally been used to treat wounds and bronchial catarrh. In the current work, target proteins (EGF, PDGF, TGF, VEGF) implicated in wound healing were analyzed using in silico computational analysis of chosen active phytoconstituents of Tridax procumbens. Studies have shown that these targets are essential in wound healing and injury repair. This study aims to see if Caffeic acid, Epicatechin, Kaempferol, and Tannic acid can bind to and enhance the activity of specific proteins. The current research relies heavily on a computer-based molecular docking tool that simulates the in vivo situation and uses a unique algorithm to evaluate a ligand molecule's binding affinity and pose to a receptor. According to the findings, tannic acid had a great affinity with all of the target proteins studied in this investigation. Thus, this chemical should be investigated further as a potential therapeutic candidate.