A new bromopyrrole alkaloid (1) along with (+/-)-2 and (+/-)-longamide (3) has been isolated from the Japanese marine sponge Homaxinella sp. The structures of the compounds were proposed on the basis of spectroscopic data. The optical resolution of (+/-)-2 by chiral HPLC was successful and afforded the two enantiomers, (+)-2 and (-)-2.