Effects of bromide (Br) and iodide (I) concentrations, chlorine (Cl2) doses, pH, temperature, ammonia nitrogen concentrations, reaction times and water characteristics on formation of iodinated trihalomethanes (I-THMs) during oxidation of iodide containing water with chlorine were investigated in this study. Results showed that the yields of I-THMs increased with the high bromide and iodide level during chlorination. The elevated pH significantly increased the yields of I-THMs during chlorination. The formation of I-THMs was higher at 20°C than 4°C, 10°C and 30°C. In chloramination study, addition of ammonium chloride (NH4Cl) markedly increased the formation of I-THMs. Among the water samples collected from seven water sources including wastewater treatment plant (WWTP) effluent water (EfOM water), prepared humic containing water (HA water) and algal organic matter (AOM) containing water (AOM water), EfOM water generated the highest yields of I-THMs (12.31 μg/mg DOC), followed by HA water (4.96 μg/mg DOC), while AOM water produced the lowest yields of I-THMs (0.99 μg/mg DOC). SUVA254 values of EfOM water , HA water and AOM water were 1.38 L/mg・m, 4.96 L/mg·m and 0.97 L/mg·m, respectively. The I-THMs yields had a low correlation with SUVA254 values (r = 0.002).