In the following case the patient has been under my observation during the past two years, commencing June 21, 1908. The case is a typical one of the severe type and illustrates the remissions which are so characteristic of the condition and also the manner in which the condition for the time being responds to arsenic. Patient.— D. N., unmarried, farmer, Irish, aged 58. His father died at 86; his mother died at 73 of pneumonia. Brothers all alive and well; two sisters died in infancy. History.— He had a broken leg live years ago, otherwise he has always been healthy. He has been an exceptionally hard drinker for a number of years, and is frequently drunk for days at a time. Six months ago he took cold after exposure during a drunken spree and has not recovered. He complains of general weakness especially of the legs, shortness of breath,