In this study, a simulation platform for an integrated navigation algorithm for hypersonic vehicles based on flight mechanics is designed. In addition, the generation method of inertial measurement unit data and satellite receiver data is introduced. First, the interface relationship between a high-precision six-degree-of-freedom (6DoF) model and the simulation platform in the launch-centered Earth-fixed frame is introduced. Three-axis theoretical specific force and angular velocity are output by the 6DoF model. Accelerometer and gyroscope error models are added, and integral processing of the specific force and angular velocity is performed to obtain velocity increment of the accelerometer and the angular increment of the gyroscope. These data are quantified to obtain the accelerometer and gyroscope pulses. The satellite’s pseudo-range and pseudo-range rate as well as its position and velocity are obtained from the theoretical position, velocity, the attitude of the hypersonic vehicle’s 6DoF model output, and the global positioning system (GPS) satellite broadcast ephemeris. The simulation data can be used for the verification of the loose and tight coupling integrated navigation algorithms. The simulation test verifies the accuracy of the designed method.