At elevated temperatures, the nickel-base superalloy IN718 is prone to the failure type ‘dynamic embrittlement’. Dynamic embrittlement is assumed to be driven by tensile stress-controlled oxygen grain boundary diffusion. Oxygen embrittles the grain boundaries in front of a crack and results in a fast brittle intercrystalline crack propagation. In order to reveal the mechanism of dynamic embrittlement, high temperature fatigue crack propagation tests were carried out at 650 °C in vacuum and air applying various dwell times and testing frequencies. The crack growth was monitored by the ACPD technique and a far-field microscope. The observations show that at low stress intensity factor ranges, crack propagation mainly occurs in the unloading and loading parts of the cycle and only minor crack propagation takes place during the dwell time. With increasing dwell time, the contribution of the crack propagation at constant stress increases. A mechanism-based model was developed on the basis of these findings which allows for a quantitative description of the effect of dynamic embrittlement on fatigue crack propagation rate. The results of respective simulations correspond very satisfactorily to the experimental data. Hence, the model is suitable for lifetime assessment.