British Participants Research Articles

Disentangling the good, the bad, and the neutral of co-present mobile phone use: A new perspective on “partner phubbing”

Studies show that the use of smartphones in the presence of a partner may result in lower relationship quality, intimacy, and increased conflict. Such co-present phone use, often referred to as “phubbing” or “technoference,” has been problematized in the literature. However, few studies have hitherto explored the possibility that using phones in each other's presence may not cause any relational harm and might even support relationship maintenance. Only recently did the critiques and theoretical frameworks begin to expand our understanding of the broader role of smartphones in dyadic interactions. In this study, we tested whether co-present phone use is always perceived as negative, or if it could also be neutral or positive. We employed quantitative methods and content coding of free responses to understand the participants’ experiences and reasoning in different evaluations. We analyzed the responses of British participants ( N = 383) living with their partner, who were enrolled via Prolific to take part in the study. The analyses revealed that only 15% of participants perceived their partner's phone use as negative, the majority evaluating it as neutral or positive. Most participants reported that their partner's phone use had no impact on their time together or was integrated with other activities. Those who reported a negative impact attributed it to the partner's lack of attention. The present study challenges the existing literature and highlights the need for a conceptual expansion of smartphone-related behaviors in dyads.

Assessing Association Between Circulating Bilirubin Levels and the Risk of Frailty: An Observational and Mendelian Randomization Study.

Bilirubin is a by-product of haemoglobin breakdown and has been reported to be a potent antioxidant recently. While elevated levels of bilirubin have been linked to a reduced risk of various diseases, their role remains unknown in frailty. This study aims to explore the relationship between serum bilirubin levels and the risk of frailty. This cohort study included 442 223 White British participants (aged 39 to 73 years) with an available frailty index at baseline (2006 to 2010) from the UK Biobank. The associations of total/direct bilirubin levels with the continuous frailty index were analysed by multivariable linear regression, and multivariable logistic regression was used after classifying frailty outcomes into non-frailty, pre-frailty and frailty. A Mendelian randomization (MR) analysis was applied to evaluate the association of genetically predicted bilirubin levels with frailty risk. The prevalence rates of both pre-frailty and frailty were 46.17% and 12.49%, respectively, with higher rates observed in women than in men (pre-frailty: 47.33% vs. 44.79%, frailty: 13.64% vs. 11.13%, respectively). There was a non-linear negative association between total bilirubin levels and frailty indexes (p < 0.0001). Mildly elevated total bilirubin levels had protective effects against pre-frailty (OR = 0.863, 95% CI: 0.849 to 0.879, p < 0.001) and frailty (OR = 0.660, 95% CI: 0.641 to 0.679, p < 0.001). Increased total bilirubin levels were more beneficial for women with frailty risk (percent changes per SD μmol/L = -0.37%, 95% CI: -0.40% to -0.34%). The MR analysis revealed a negative association between genetically predicted total/direct bilirubin levels and frailty risk (both p < 0.0001). Circulating total/direct bilirubin levels were negatively associated with frailty risk in White British individuals. Mildly elevated total bilirubin levels were more beneficial for women subpopulation.

“The Voice of Agitation Should Roll across the Broad Atlantic”

Abstract Scholars have provided impressive analyses of the transatlantic slave trade to the Americas and its demise over the past four decades, this led by contributions to the Trans-Atlantic Slave Trade Database ( https://www.slavevoyages.org/ ). England played a decisive role in the suppression of that traffic after prohibition of British participation in 1808, this partly achieved by British interceptions of slave vessels by its West Africa Squadron (1819–1867) and the establishment of Courts of Mixed Commission for the Abolition of the Slave Trade (1819–1871). Given a North Atlantic Ocean current clockwise gyre and South Atlantic counterclockwise gyre, a major northern slave vessel route connected Africa to the Caribbean and a second southern route connected Africa to Brazil.1 Africans disembarked in the Caribbean had diverse origins in West Africa (Sierra Leone, Ghana, Togo, Nigeria) and West Central Africa (Congo, Angola). Brazil received fewer Africans from West Africa (there was a long-term connection between Benin and Bahia), large numbers of African slaves from West Central Africa and a small number from Southeast Africa (Mozambique) at or near Rio de Janeiro. Language difference (Spanish, French, English, Dutch, Danish in the North Atlantic, Portuguese in the South Atlantic) contributed to a conceptual separation of those two regions, particularly evident in historiographies related to slavery and abolition. The Scottish diplomat David Turnbull was one of the few observers of the nineteenth century who connected Caribbean islands with Brazil. Turnbull asserted to the British Foreign Office that subaltern resistance by slaves and free blacks in both the British and non-British Caribbean could aid in England’s quest to extinguish the transatlantic slave trade. Turnbull organized a petition campaign in Jamaica in the late 1840s to pressure England’s Foreign Office to pursue more aggressive actions at sea and on land to halt slave disembarkations in Cuba and Brazil. Foreign Secretary Lord Palmerston’s positive response combined with slave resistance in Brazil contributed to Brazil’s imperial government decision to act decisively to halt further slave disembarkations in 1850–1851.

Combined Effect of Air Pollution and Genetic Risk on Incident Cardiovascular Diseases.

Whether genetic susceptibility to cardiovascular diseases (CVDs) enhances the vulnerability to adverse cardiovascular outcomes by air pollution is unknown. We assessed the combined effect of air pollution and genetic predispositions on CVD risk. From the UK Biobank cohort, we selected genetically unrelated White British participants without CVD. Levels of ambient particulate matter with a diameter of <2.5 μm (PM2.5) and <10 μm were estimated using land use regression models. An individual's genetic predisposition to CVDs was determined by polygenic risk scores for coronary artery disease, myocardial infarction, stroke, ischemic stroke, heart failure, and atrial fibrillation. We stratified mortality and CVD risk by PM2.5 exposure across high and low genetic risk groups. A total of 249 082 participants (aged 56.9±8.0 years, 46.8% men) were followed for a median of 10.8 years. The combined effect of PM2.5 exposure and the genetic predisposition of CVD demonstrated the highest risk of cardiovascular death in the high genetic risk group with the greatest PM2.5 exposure (adjusted hazard ratios ranging from 1.73 to 2.12 across the polygenic risk score of each CVD). The combination of higher exposure to ambient PM2.5 and high genetic risk was associated with higher incidence of all CVDs, although no significant interactions were observed between genetic risk and PM2.5 exposure on cardiovascular death or CVD events. A combination of greater PM2.5 exposure and higher genetic predisposition to particular CVDs was modestly associated with elevated risks of cardiovascular death and CVDs. Not only alleviating PM2.5 exposure in the general population but also implementing individualized preventive approach for those at high genetic risk might be beneficial.

Ethnic Inequalities in the Functional Dentition Among British Adults: A Multilevel Analysis.

To explore the role of socioeconomic factors, area deprivation and behaviours in explaining ethnic differences in the functional dentition among East London adults using multilevel modelling. Data from a community-based health survey in East London included information on 1898 adults aged between 16 to 65 years old and belonging to 9 ethnic groups. Supervised questionnaires gathered information on demographic characteristics, socioeconomic indicators, dental behaviours and area deprivation (IMD 2007). A functional dentition was defined as having all 6 anterior plus at least 4 posterior contacts in clinical examination. The multilevel logistic regression showed that Black Africans were 75% (95%CI: 1.21-2.52) and Black Caribbean 77% (95%CI: 1.05-2.98) more likely to have a non-functional dentition than White British participants in fully adjusted models. Other factors associated with a non-functional dentition were older age and no educational attainment. Black adults are at greater risk of non-functional dentition independently from sociodemographic characteristics, oral health-related behaviours and area-level characteristics. Proportionate universalism could be effective in reducing these health gaps.

Cross-country variation in psychophysiological responses to traffic noise exposure: Laboratory experiments in India and the UKa).

Traffic noise exposure has detrimental effects on human health, including both auditory and nonauditory impacts. As one such nonauditory factor, individuals and communities in different countries may exhibit different patterns of noise sensitivity and corresponding tolerance levels, leading to a change in overall noise perception. This paper investigated the cross-country differences in psychophysiological responses to traffic noise exposure between Indian and British individuals. A psychophysiological signal-based [heart rate variability (HRV) and skin conductance response (SCR)] listening experiment was conducted in India and the United Kingdom to analyze changes in noise perception and psychophysiological responses resulting from exposure to the same noise stimuli. HRV analysis indicated greater cardiovascular impact in the British group due to a significant increase in heart rate (W = 653, p < 0.01). Also, a significant increase in the SCR (W = 535, p < 0.001) was noted, indicating a greater level of physiological stress among British participants due to traffic noise stimuli. These findings highlight the difference in noise perception due to cross-country variation using psychophysiological responses. Understanding these cross-country differences can inform targeted interventions and policies to mitigate the adverse effects of traffic noise on human well-being.

Debunking the corporate paint shop: Examining the effects of misleading corporate social responsibility claims on social media

Misinformation thrives on social media, prompting much research into social media interventions such as debunks. This paper tests debunking’s effectiveness against an understudied but prominent form of online misinformation: misleading organizational claims of corporate social responsibility, or CSR-washing. British participants ( N = 657) took part in a preregistered experiment with a 2 (debunk: present, absent) x 3 (CSR-washing: greenwashing, bluewashing, purplewashing) between-subjects design. They saw an Instagram ad from a fictional clothing company that showcased its dedication to environmental sustainability, gender equality in the workplace, or the elimination of child labor. Half of the participants then received a debunk. Unlike most previous research which showed continued influence of misinformation after debunking, we found that the debunks were very effective: they reversed the persuasive effects of CSR-washing, resulting in negative brand attitudes and low purchase intentions. Several explanations for this finding are discussed, highlighting CSR-washing’s distinctiveness from many other forms of misinformation.

Ultra-processed food consumption and risk of coronary heart diseases: UK Whitehall II cohort study

Abstract In recent decades, ultra-processed foods (UPFs) intake has increased drastically, sparking concerns about their potential impact on cardiometabolic diseases. However, large-scale cohort studies tracking UPF consumption at multiple time points remain limited. This study explores the prospective association between repeated measures of UPF intake and the risk of coronary heart disease (CHD), along with its secondary endpoints, within the UK Whitehall II study. The analytical sample tracked 7,138 midlife British participants without CHD from baseline. UPF consumption was measured using validated food frequency questionnaire (127 items) and classified by the NOVA system during three phases: 1991/1994 (phase 3), 1997/1999 (phase 5), and 2002/2003 (phase 7). This study assessed the onset of CHD and its secondary endpoints, including CHD and all-cause mortality, through medical exams and hospital records up to 2016 and 2021, respectively. Cox proportional hazards regression models adjusted for socio-demographics, lifestyle factors and total energy intake were used to explore the prospective association between cumulative average UPF intake (in quintiles) and CHD outcomes. During a median follow-up of 13 and 19 years, 589 cases and 1,314 deaths were documented. In multivariable adjusted cox models, the highest UPF consumption quintile versus the lowest quintile was associated with higher CHD incidence [HR:1.26; 95% Confidence Interval (CI): 1.02-1.55; p = 0.03]. Additional adjustment of total energy intake increased the CHD risk by 28% [HR:1.28; 95% CI: 1.03-1.58; p = 0.02]. No significant relationships were found between cumulative average UPF intake and CHD or all-cause mortality. In UK midlife adults, higher UPF intake is prospective associated with increased CHD risk. Although additional research is warranted, these findings emphasize the importance of public awareness and food policy interventions to reduce UPF intake for alleviating the population burden of CVD. Key messages • Our study suggests the need for increased efforts to implement population wide strategies on regulating food processing, such as taxation and front of package warning labelling of UPF. • Our study emphasizes UPF’s role in cardiovascular prevention, highlighting the need for nutrition counseling on UPF consumption for those at risk of CVD.

Differences in ambulatory versus home blood pressure levels by ethnicity: data from the United Kingdom and Japan.

This study tested the hypothesis that differences in ethnicity impact the level of agreement between ambulatory blood pressure (ABP) and home BP (HBP) levels. A retrospective analysis of cross-sectional data from the UK and Japan was performed. Participants underwent office BP, daytime ABP, and HBP measurements. The ABP-HBP difference was compared between ethnic groups by multiple linear regression analysis. Diagnostic disagreement was defined as a disparity between the hypertension diagnoses obtained using ABP and HBP, since both measures share common thresholds of 135/85 mmHg for hypertension. Definite diagnostic disagreement was assigned where such a difference exceeded ±5 mmHg for either systolic BP (SBP) or diastolic BP (DBP). A total of 1 408 participants (age 62.1 ± 11.1 years, 48.6% males, 78.9% known hypertensive, White British 18.9%, South Asian 11.2%, African Caribbean 12.0%, Japanese 58.0%) were eligible. More Japanese participants showed higher ABP than HBP compared to White British: SBP + 3.09 mmHg, 95% confidence interval (CI) + 1.14, +5.04 mmHg; DBP + 5.67 mmHg, 95%CI + 4.51, +6.84 mmHg. More Japanese participants than African Caribbean participants exhibited diagnostic disagreement in SBP (33.2% vs. 20.7%, p = 0.006). Furthermore, Japanese participants had a higher percentage of definite diagnostic disagreement in SBP compared to White British (9.3% vs. 4.5%, p = 0.040) and African Caribbean participants (9.3% vs. 3.0%, p = 0.018). In conclusion, Japanese participants showed greater disparity between ABP and HBP compared to White British participants. Complementary use of ABP and HBP monitoring may be more beneficial for assessing cardiovascular disease risk in Japanese participants compared to other ethnic groups.

A phenome-wide association study of polygenic scores for selected childhood cancer: Results from the UK Biobank

The aim of this study was to scan phenotypes in adulthood associated with polygenic risk scores (PRS) for childhood cancers with well-articulated genetic architectures: acute lymphoblastic leukemia (ALL), Ewing sarcoma, and neuroblastoma to examine genetic pleiotropy. Furthermore, we aimed to determine which single nucleotide polymorphisms (SNPs) could drive associations. Per-SNP summary statistics were extracted for PRS calculation. Participants with white British ancestry were exclusively included for analyses. SNPs were queried from the UK biobank genotype imputation data. Records from the cancer registry, death registry, and inpatient diagnoses were abstracted for phenome-wide scans. Firth logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) alongside corresponding p-values, adjusting for age at recruitment and sex. A total of 244,332 unrelated white British participants were included. We observed a significant association between ALL-PRS and ALL (OR: 1.20e+24, 95% CI: 9.08e+14-1.60e+33). In addition, we observed a significant association between high-risk neuroblastoma PRS and nonrheumatic aortic valve disorders (OR: 43.9, 95% CI: 7.42-260). There were no significant phenotype associations with Ewing sarcoma and neuroblastoma PRS. Regarding individual SNPs, rs17607816 increased the risk of ALL (OR: 6.40, 95% CI: 3.26-12.57). For high-risk neuroblastoma, rs80059929 elevated the risk of atrioventricular block (OR: 3.04, 95% CI: 1.85-4.99). Our findings suggest that individuals with genetic susceptibility to ALL may face a lifelong risk for developing ALL, along with a genetic pleiotropic association between high-risk neuroblastoma and circulatory diseases.

Compliance with COVID-19 government guidance and rules by disabled people and people from minoritised ethnic groups: Qualitative findings from the CICADA study.

Within the 2020/21 CICADA (Coronavirus Intersectionalities: Chronic Conditions or Disabilities and Migrants and other Ethnic minorities) study, we explored full, partial or noncompliance with government COVID-19 infection-containment measures by people from minoritised ethnic groups with a disabling health condition or impairment. We used an assets-based intersectional approach and purposive sampling, included non-disabled and White British comparators, and trained community co-researchers to help us reach undocumented migrants and asylum seekers. We undertook 271 semi-structured qualitative interviews, followed by participatory workshops with interviewees to explore data and changes in experiences five and 10 months after the interviews. Perceiving their vulnerability to COVID-19, most participants quickly and often zealously adopted infection-containment behaviours, and continued this after restrictions were lifted. This could reduce mental wellbeing, especially in community-facing cultures, and could create family conflict. Various structural inequities impeded compliance. Many, especially undocumented migrants, felt imprisoned. The intersection of gender, citizenship, socioeconomic status and culture impacted disclosures of COVID-19 infection, support seeking and use. Many were unclear what was safe as well as unsafe. People complained that disability and cultural considerations were omitted from policymaking. Participants mostly had taken the COVID-19 vaccine by October 2022, but ethnic minority participants needed time to deliberate and trusted, community-embedded information whereas White British participants were mostly influenced by mass media. The intersection of health condition or impairment, poverty, and living alone led to more non-compliance with general rules, and more vaccine hesitancy than did misinformation spread through ethnic community channels. Many participants were reluctant to reintegrate in May 2022 because of continued perceived vulnerability to COVID-19 but by September 2022 = seemed more concerned about the economic crisis. We add two new 'types' to existing compliance typologies: deliberators (who eventually decide to follow the rules), and 'necessity-driven non-compliers' who are totally unable to comply because of their disabilities.

“Until COVID-19 Do Us Part”: A Qualitative Study on Perceived Sexual Intimacy and Mental Health in Heterosexual Older Couples During The Covid-19 Pandemic

AbstractThis study aims to explore the influence of the COVID-19 pandemic on heterosexual older couples’ sexual intimacy and in relation to their mental health. A content analysis of the ideas and insights shared by 391 older persons (between 65 and 87 years of age) from three different countries was most instructive. The most frequent themes were less sexual satisfaction (68%) and less sexual desire (67%). In terms of mental health, the most frequent themes included less anxiety and distress (78%) and greater attention to negative emotional states (55%) Cultural differences emerged, with Brazilian and Portuguese participants more frequently reporting negative themes compared to British participants, who emphasized stronger emotional bonds. As the COVID-19 pandemic continues to unfold, ongoing research and interventions should prioritize understanding and addressing the implications of reduced physical contact and heightened emotional stress on sexual intimacy.

Are ethnic inequalities in adult oral health-related quality of life modified by immigration status?

To explore ethnic inequalities in oral health-related quality of life (OHRQoL) and the role of nativity status on them. Data from 1868 adults (16-65 years) of 9 ethnic groups participating in a community-based health survey in East London. Participants completed a supervised questionnaire including the Oral Health Impact Profile (OHIP-14) to calculate prevalence, extent and severity of oral impacts. Associations between ethnicity and nativity status (individually and combined) with OHRQoL were assessed in regression models, crude and adjusted for socio-demographic factors and clinical oral health indicators. Black others showed higher prevalence (OR: 1.91; 95%CI 1.05-3.46), severity (IRR: 2.87, 95%CI 1.63-5.06) and extent of oral impacts (IRR: 1.86, 95%CI 1. 35-2.59). Oral impacts were more severe among Black Caribbeans (IRR: 2.85, 95%CI 1.31-6.18) and Bangladeshis (IRR: 3.08, 95%CI .07-8.91); whereas impacts were more extensive among Pakistanis (IRR: 1.54, 95%CI 1.05-2.25) and Bangladeshis (IRR: 1.87, 95%CI 1.16-3.00). Nativity status individually showed no association with OHRQoL, although when combined with ethnicity resulted in many minority groups showing worse OHRQoL than White British participants. Ethnicity and nativity status have a combined and important role in OHRQoL: ethnic minority groups showed worse OHRQoL even when controlling for clinical oral status.

Depression in older adults and its associations with sleep and synaptic density

BackgroundDepression among older adults is a global concern, contributing to disability and overall illness burden. Understanding its trajectory, associated risk factors, and implications for mortality is essential for effective intervention. Moreover, the relationship between depression, sleep disturbances, and synaptic density in the ageing brain remains complex and poorly understood. MethodsUsing data from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age cohort, comprising 6375 participants, we conducted comprehensive assessments of depression trajectories using generalized linear mixed models and mortality risks using Cox mixed-effects models. Generalized structural equation modelling was performed to explore longitudinal associations between sleep duration and depression. Lastly, associations between post-mortem synaptic density and depression were investigated. ResultsOur findings revealed that depression rates declined until age 80 before increasing again. Depression was associated with a 10 % increased risk of mortality in older adults. Reduced sleep was correlated with depression, and depression measured early in the study predicted future reduced sleep. Post-mortem analysis showed a global reduction in synaptic density associated with depression, particularly pronounced in the frontal lobe. LimitationsLimitations include recall bias, limiting generalizability due to dominantly including White British participants and difficulty in establishing causation between synaptic density and depression. ConclusionOur study underscores the significance of addressing depression in older adults, not only for mental health but also for mortality risk and neurobiological health. Early detection and intervention strategies are crucial for improving outcomes in elderly populations, potentially mitigating adverse effects on sleep, synaptic density, cognitive health, and longevity.

Evidence Against Effects of Cultural Group and Prior Knowledge on Feature Binding in Working Memory.

Feature binding is the process of integrating features, such as colour and shape, into object representations. A persistent question in the literature concerning whether feature binding is an automatic or resource-demanding process may depend on unitisation, that is, whether the to-be-bound information is intrinsic (belonging to) or extrinsic (contextual). Given extensive evidence showing that Easterners may process information more holistically than Westerners, such cultural differences may be useful to understand the fundamental processes of feature binding in visual working memory (WM). Accordingly, we recruited British and Chinese participants to complete a visual WM task wherein to-be-remembered colours were integrated within (i.e., intrinsic binding) or as backgrounds (i.e., extrinsic binding) of to-be-remembered shapes (Experiments 1 and 2). Experiment 2 further investigated the role of prior knowledge in long-term memory to facilitate feature binding in WM. During retrieval, participants decided among three probes: a target, a lure (i.e., recombination of the presented features), and a new colour/shape. Hierarchical Bayesian multinomial processing tree models were fit to the data to estimate parameters representing binding and item memory. The current results suggest that intrinsic and extrinsic binding memory are similar between the two cultural groups, with no prior knowledge benefits for either intrinsic or extrinsic binding for either cultural group. This result conflicts with the Analytic and Holistic framework and suggests that there are no cultural differences or prior knowledge benefits in feature binding.

The Effect of Climate Change Threat on Public Attitudes towards Ethnic and Religious Minorities and Climate Refugees

How does climate change threat affect attitudes towards ethnic and religious minorities and climate change refugees? We show that threatening climate change can have deep psychological effects even among social majority groups in relatively prosperous and peaceful societies. Using three survey experiments with self-identified White British participants ( N = 616, N = 587, and N = 535), we demonstrate that social majority members who are exposed to threatening information about climate change (vs. neutral information) and, at the same time, feel little national efficacy over climate change, evaluate more negatively certain ethnic and religious minorities, especially Muslims and Pakistanis. We found the same trend in the evaluation of climate refugees, although it reached statistical significance only in one of the experiments. We explain these reactions as pertaining to groups that are perceived as threatening the salient ingroup and its collective agency. Our research significantly contributes to the literature on the social and political implications of (climate change) threat, especially by focusing on boundary conditions, namely the perception of collective control in case of complex and large threats.

Thought contagion? Conspiracy beliefs boost paranoid thoughts.

Conspiracy theories accusing specific groups of secret malevolent actions can foster a perception of the world as a dangerous place. In our research, we contend that both adherence and exposure to conspiracy beliefs can serve as a potential cause of certain psychological problems in the form of paranoid thoughts. This hypothesis was tested in three studies conducted among Polish and British participants. In Study 1 (longitudinal, N = 603), we found that conspiracy beliefs exerted a positive overtime effect on paranoid thoughts. Experimental studies 2 (N = 384) and 3 (N = 445), showed that being exposed to conspiracy theories (vs. control stimuli) heightened paranoid thoughts. In Study 3, we proposed a potential mechanism explaining this effect, according to which exposure to conspiracies increased paranoid thoughts via only negative intense emotions. Our work adds to the discussion on the consequences of conspiracy beliefs and has implications for mental health research, underlining the importance of designing interventions limiting the adverse effects of conspiracy beliefs.

Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis

BackgroundComputer gaming has recently been suggested to be associated with benefits for cognition, but its impact on incident dementia remains uncertain. We aimed to investigate the observational associations of playing computer games with incident dementia, cognitive functions, and brain structural measures, and further explore the genetic associations between computer gaming and dementia.MethodsWe included 471,346 White British participants without dementia at baseline based on the UK Biobank, and followed them until November 2022. We estimated the risk of dementia using Cox proportional hazard models, and assessed the changes of cognitive functions and brain structural measures using logistic regression models and linear regression models. Mendelian randomization (MR) analyses were performed to examine the association between genetically determined computer gaming and dementia.ResultsHigh frequency of playing computer games was associated with decreased risk of incident dementia (HR, 0.81 [95% CI: 0.69, 0.94]). Individuals with high frequency of playing computer games had better performance in prospective memory (OR, 1.46 [1.26, 1.70]), reaction time (beta, -0.195 [-0.243, -0.147]), fluid intelligence (0.334 [0.286, 0.382]), numeric memory (0.107 [0.047, 0.166]), incorrect pairs matching (-0.253 [-0.302, -0.203]), and high volume of gray matter in hippocampus (0.078 [0.023, 0.134]). Genetically determined high frequency of playing computer games was associated with a low risk of dementia (OR, 0.37 [0.15, 0.91]).ConclusionsComputer gaming was associated with a decreased risk of dementia, favorable cognitive function, and better brain structure, suggesting that computer gaming could modulate cognitive function and may be a promising target for dementia prevention.

Kidney Volume and Risk of Incident Kidney Outcomes.

Low total kidney volume (TKV) is a risk factor for chronic kidney disease (CKD). However, evaluations of nonlinear relationships, incident events, causal inference, and prognostic utility beyond traditional biomarkers are lacking. TKV, height-adjusted TKV, and body surface area-adjusted TKV (BSA-TKV) of 34,595 White British ancestry participants were derived from the UK Biobank. Association with incident CKD, acute kidney injury (AKI), and cardiovascular events were assessed with Cox proportional hazard models. Prognostic thresholds for CKD risk stratification were identified using a modified Mazumdar method with bootstrap resampling. Two-sample Mendelian randomization was performed to assess the bidirectional association of genetically predicted TKV with kidney and cardiovascular traits. Adjusted for eGFR and albuminuria, a lower TKV of 10 mL was associated with a 6% higher risk of incident CKD (hazard ratio [HR] 1.06, 95% confidence interval [CI] 1.03 to 1.08, P = 5.8 x 10-6) in contrast to no association with incident AKI (HR 1.00, 95% CI 0.98 to 1.02, P = 0.66). Comparison of nested models demonstrated improved accuracy over the CKD Prognosis Consortium Incident CKD Risk Score with the addition of BSA-TKV or prognostic thresholds at 119 (10th percentile) and 145 mL/m2 (50th percentile). In Mendelian randomization, a lower genetically predicted TKV by 10 mL was associated with 10% higher CKD risk (odds ratio [OR] 1.10, 95% CI 1.06 to 1.14, P = 1.3 x 10-7). Reciprocally, an elevated risk of genetically predicted CKD by 2-fold was associated with a lower TKV by 7.88 mL (95% CI -9.81 to -5.95, P = 1.2 x 10-15). There were no significant observational or Mendelian randomization associations of TKV with cardiovascular complications. Kidney volume was associated with incident CKD independent of traditional risk factors including baseline eGFR and albuminuria. Mendelian randomization demonstrated a bidirectional relationship between kidney volume and CKD.

Shifting norms, static behaviour: effects of dynamic norms on meat consumption.

While decreasing their meat consumption is one of the most impactful behaviours an individual may carry out to reduce their carbon emissions, it is still a minority behaviour in many parts of the world. Research suggests that communicating information about changing 'dynamic' norms may be a useful tool for changing attitudes and behaviours in the direction of those currently held by the minority. This study uses a 2 × 2 mixed design (norm type [dynamic/static] × visual cue [present/absent, and a no-task control), and a follow-up assessment after one week to investigate the effect of making dynamic norms salient on various meat consumption outcomes: attitudes towards meat consumption, interest in reducing one's own meat consumption, intentions to reduce one's own meat consumption and self-reported meat consumption. We used an online sample of British participants (N = 1294), ranging in age 18-77 (M age = 39.97, s.d.age = 13.71; 55.8% female). We hypothesized that: (i) dynamic norms will positively influence meat consumption outcomes; (ii) visual cues will accentuate the difference between norm conditions; (iii) using a visual cue will enhance the effect of dynamic norms; and (iv) any effects of dynamic norms will endure over a period of one week. We found no positive effect of dynamic norms (versus static norms) on any outcome at time 1, and no positive effect on changes in outcomes from time 1 to time 2. However, we found a positive interaction of norm type and visual cue at time 1 (although not from time 1 to time 2): the addition of a visual cue to dynamic norm messages enhanced the positive effect of the message at time 1 (but did not enhance the changes occurring from time 1 to time 2). Analyses for changes in self-reported meat consumption did not reach our evidential threshold. We discuss the practical and theoretical implications of these findings.