Air Breathing Research Articles

Indikasi Kegagalan Pembangunan Berkelanjutan dari Implementasi Program CSR

The presence of multinational companies entering Indonesia has both positive and negative impacts on the communities around the company. The positive impacts that arise include the emergence of new jobs, new economic growth. The negative impacts that arise include environmental damage, pockets of poverty, crime and others. Efforts made by the company to reduce the negative impacts resulting from company activities through CSR programs. The CSR program run by the company adheres to a sustainable development approach where the company's activities do not interfere with the continuity of life for the next generation. A popular approach is the triple bottom line, namely a balance between people, planet and profit. In reality, the activities carried out through the CSR program have not had a positive impact on society, in fact there are still many negative impacts. This article attempts to examine why the implementation of CSR carried out by companies has not been able to provide positive results to society, especially in sustainable development efforts, what factors are behind sustainable development not being realized. The research method usesSystematic Literature Review (SLR). The results and discussion are that the existence of multinational companies in Indonesia in processing natural resource wealth does have big implications. The CSR concept that is developing with the idea of ​​sustainable development is a breath of fresh air in the development of this nation. But in reality, the CSR program that was implemented then fell short of expectations. The sustainable development campaign promoted by the company in the form of CSR is still limited to perpetuating the company's interests. The idea of ​​strong capitalism by multinational companies must be controlled by this country, especially the role of government and civil society.

Resilience of Personalized Ventilation in Maintaining Acceptable Breathable Air Quality When Combined with Mixing Ventilation Subject to External Shocks

This work evaluates the ventilation resilience of the combined personalized ventilation (PV)-mixing ventilation (MV) system when implemented in a typical office space. This resilience is first evaluated by monitoring the ability of the PV devices when designed at different supply flow rates to maintain acceptable levels of CO2 at the occupant’s breathing zone when the MV system is subjected to a shock. The shock considers a malfunction of the MV system for periods of 3 h and 6 h, and at shutoff percentages of MV fan flow of 100% and 50%. This is followed by evaluating the resilience of the MV system when the PV air handling unit is shutoff for short periods. The following three aspects of resilience were calculated: the absorptivity, the recovery, and the resilience effectiveness. To monitor the CO2 temporal variation at the breathing zone, a computational fluid dynamic model was developed and validated experimentally. It was found that the resilience effectiveness varied between 0.61 (100% MV shutoff for 6 h and PV at 4 L/s) and 1 (50% MV shutoff for 3 h and PV at 13 L/s). Additionally, CO2 build-up and recovery took minutes during MV malfunctions and seconds during PV malfunctions.

Microglial reactivity in brainstem chemosensory nuclei in response to hypercapnia.

Microglia, the resident immune cells of the CNS, surveil, detect, and respond to various extracellular signals. Depending on the nature of these signals, an integrative microglial response can be triggered, resulting in a phenotypic transformation. Here, we evaluate whether hypercapnia modifies microglia phenotype in brainstem respiratory-related nuclei. Adult C57BL/6 inbred mice were exposed to 10% CO2 enriched air (hypercapnia), or pure air (control), for 10 or 30min and immediately processed for immunohistochemistry to detect the ubiquitous microglia marker, ionized calcium binding adaptor molecule 1 (Iba1). Hypercapnia for thirty, but not 10min reduced the Iba1 labeling percent coverage in the ventral respiratory column (VRC), raphe nucleus (RN), and nucleus tractus solitarius (NTS) and the number of primary branches in VRC. The morphological changes persisted, at least, for 60min breathing air after the hypercapnic challenge. No significant changes were observed in Iba1+ cells in the spinal trigeminal nucleus (Sp5) and the hippocampus. In CF-1 outbred mice, 10% CO2 followed by 60min of breathing air, resulted in the reduction of Iba1 labeling percent coverage and the number and length of primary branches in VRC, RN, and NTS. No morphological change was observed in Iba1+ cells in Sp5 and hippocampus. Double immunofluorescence revealed that prolonged hypercapnia increased the expression of CD86, an inflammatory marker for reactive state microglia, in Iba1+ cells in VRC, RN, and NTS, but not in Sp5 and hippocampus in CF-1 mice. By contrast, the expression of CD206, a marker of regulatory state microglia, persisted unmodified. In brainstem, but not in hippocampal microglia cultures, hypercapnia increased the level of IL1β, but not that of TGFβ measured by ELISA. Our results show that microglia from respiratory-related chemosensory nuclei, are reactive to prolonged hypercapnia acquiring an inflammatory-like phenotype.

Unnatural nature – visual, spatial, and temporal contexts controlling our air

The article is the result of the collaboration of a sociologist and librarian who have photodocumented the Sagamore Hill National Historic Site for decades to study the changed ecology, revaluation of landscape, and the sense of nature, changing overtime. The research methods included archival research, field interviews, and comparative documentation. The visual, spacial, and temporal contexts controlling the air we breathe include: the historic contexts of natural formations, the stewardships by the Roosevelt Family, TR Association, the National Park Service management, and the dynamic interactions of people on the site. The documents are studied to theorize the larger socio-cultural changes, altering our visions and the social construct of nature. The aspects of breathing air and life itself, and the desirability of safe, healthy enjoyable public spheres emerge and make this case study useful for comparative analysis.

Inovasi Pelayanan Publik Menggunakan Co Creation

Public service is a motivation for the public. The existence of a public service can be a control over arbitrariness in the hands of policy makers. Innovation in public services helps the government further upgrade the conditions of its territory. Law No. 25 of 2009 concerning Public Services is a breath of fresh air in efforts to provide good public services. This law mandates that public service is an activity or series of activities in order to fulfill service needs in accordance with statutory regulations for every citizen. Public service innovation cannot be separated from community participation. Public service innovation is also used in Bandung where co-creation methods are used to improve public services. This method is used by the Bandung Dukcapil Office. The application of co-creation is a new breakthrough in data openness and also the accuracy of data from the government

Impact of cadmium chloride’s toxicity on oxygen consumption in an air breathing teleost Heteropneustes fossilis (Bloch)

Metabolic demand of oxygen maintained by the utilization of dissolved oxygen from aquatic medium by respiratory organs in piscian fauna. Heteropneustes fossilis is an air breathing teleost are able to use dissolved oxygen in water through gills and atmospheric oxygen through its accessory respiratory organs known as suprabranchial chamber and air sacs. Contamination of heavy metal, cadmium chloride through industrial discharge in water body, produce histological alteration and toxicological impact on gills and accessory respiratory organs which decrease the efficiency of oxygen consumption and leads serious threat for survival of fish. By acquiring the effect of toxic pollutant in aquatic medium, its discharge into nearby water resources may be regulated to protect aquatic life and its effect on the human consumption.

Numerical analysis of thermal performance of breathing air cooler based on granular phase change material

In this paper, we propose to use granular phase change material (PCM) as a heat accumulating material in a thermal protective respirator also called a heat exchanger to cool the breathing air. Such device is needed to protect human respiratory system from thermal injuries at indoor fires. Using the original solver for OpenFOAM software developed and validated previously, the ability of the commercially available granular PCM in the respirator to cool hot air for breathing during the time required for the human evacuation has been shown numerically: mass of 130 g is enough to cool the air from 177 °C to a temperature of less than 50 °C within 10 min. This result gives hope that such cooling element can be combined with “conventional” gas-and-smoke protective element, resulting in the creation of respirators for the protection of a person from both hot air and toxic combustion products. A parametric study of the performance of the thermal protective respirator is carried out in the paper: effect of PCM melting temperature, time variation of the outlet air flow rate and partial closure of the outlet from the cooling element have been analyzed. It has been shown that an increase in the PCM melting temperature while keeping the other parameters unchanged worsens the thermal performance of the breathing air cooler. The cooling efficiency is also worsened when the cooling element is narrowed or its outlet is partially closed, as this leads to an increase in the maximum temperature of the inhaled air. It has been shown that the time variation of the inhaled air flow rate, which is used in the calculations of the thermal protective respirator, must be close to the parameters of real human breathing, and the use of the assumption of constant air flow rate is unacceptable, since this can significantly affect the output characteristics of the respirator.

A breath of toxic air: The relationship between appraised air pollution, abusive supervision, and laissez-faire leadership through the dual-mediating pathways of negative affect and somatic complaints.

Air pollution has become a global public health hazard leading to debilitating effects on physical, mental, and emotional health. Management research has just begun to explore the effects of air pollution on employees' work life. Drawing from the transactional theory of stress (Lazarus & Folkman, 1984) and crossover theory (Westman, 2001), we argue that appraisal of air pollution is an important factor that influences leaders and their behavior with subordinates. Specifically, we propose that when leaders appraise severe air pollution, they are more likely to behave abusively toward their subordinates and engage in laissez-faire leadership. We also propose that this relationship is mediated by leaders' experience of somatic complaints and negative affect. We test our model using an experience sampling study in India of leaders and followers who were located in different cities from each other. Overall, our results highlight how air pollution appraisals can harm not only the leader experiencing the pollution but also subordinates of those leaders. In other words, our counterintuitive finding is that subordinates may be harmed by air pollution to which they are not even directly exposed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Potential Pollutants and Indoor Air Quality Variables Association towards Implementation of the Breathing Architecture Concept: A Review

Indoor air quality is essential in improving indoor well-being since most people spend their time there. The breathing Architecture concept promotes a strategy for designing indoor space to maintain the indoor air quality. This concept has various challenges, such as indoor pollutants determining the indoor environment to be healthy and decent. This study aims to identify the relationship between IAQ variables related to Breathing Architecture and air pollutants based on secondary sources of past and existing research ten years ago. The review identified 16 articles collected by selecting several relevant keywords in ScienceDirect and screening the title and abstract. Content analysis was conducted to analyze the relationship between IAQ variables and pollutants and their potential association with the breathing architecture concept. The results show that air exchange rate, volume of spaces, relative humidity, and indoor-outdoor temperature are the most potential variables and have a possible relationship while implementing the BA concept. Using these variables, the optimal condition might be perceived since the possibility of lower pollutant contamination might be lower, and the purpose of breathing architecture might be obtained. However, the relationship between other variables and pollutants requires future studies since it is undescribed or may impact other variables.

Improvement and optimization of spacecraft environmental control and life support systems

Environmental control and life support systems (ECLSS) are essential for the triumph of human spaceflight missions, furnishing astronauts with crucial resources like breathable air, purified water, nourishment, and protection from radiation. The unique and challenging space environment, coupled with the critical nature of ECLSS components, necessitates a high degree of reliability to prevent catastrophic failures. This paper conducts a comprehensive examination of various ECLSS subsystems, including air revitalization, water processing, food storage, waste management, and radiation shielding. Gaining perspectives from historical missions like Apollo, Skylab, and the International Space Station (ISS), the research outlines strategic approaches to improve the fault tolerance of ECLSS. The implementation of advanced simulation modeling, strategic component redundancy, and improved subsystem interconnectivity are posited as pivotal measures to bolster the reliability of ECLSS. These improvements are vital to guarantee the safety and viability of prolonged space missions to the Moon, Mars, and beyond, thereby facilitating humanitys ongoing exploration of the universe.

Structure and Function of Canine SP-C Mimic Proteins in Synthetic Surfactant Lipid Dispersions.

Lung surfactant is a mixture of lipids and proteins and is essential for air breathing in mammals. The hydrophobic surfactant proteins B and C (SP-B and SP-C) assist in reducing surface tension in the lung alveoli by organizing the surfactant lipids. SP-B deficiency is life-threatening, and a lack of SP-C can lead to progressive interstitial lung disease. B-YL (41 amino acids) is a highly surface-active, sulfur-free peptide mimic of SP-B (79 amino acids) in which the four cysteine residues are replaced by tyrosine. Mammalian SP-C (35 amino acids) contains two cysteine-linked palmitoyl groups at positions 5 and 6 in the N-terminal region that override the β-sheet propensities of the native sequence. Canine SP-C (34 amino acids) is exceptional because it has only one palmitoylated cysteine residue at position 4 and a phenylalanine at position 5. We developed canine SP-C constructs in which the palmitoylated cysteine residue at position 4 is replaced by phenylalanine (SP-Cff) or serine (SP-Csf) and a glutamic acid-lysine ion-lock was placed at sequence positions 20-24 of the hydrophobic helical domain to enhance its alpha helical propensity. AI modeling, molecular dynamics, circular dichroism spectroscopy, Fourier Transform InfraRed spectroscopy, and electron spin resonance studies showed that the secondary structure of canine SP-Cff ion-lock peptide was like that of native SP-C, suggesting that substitution of phenylalanine for cysteine has no apparent effect on the secondary structure of the peptide. Captive bubble surfactometry demonstrated higher surface activity for canine SP-Cff ion-lock peptide in combination with B-YL in surfactant lipids than with canine SP-Csf ion-lock peptide. These studies demonstrate the potential of canine SP-Cff ion-lock peptide to enhance the functionality of the SP-B peptide mimic B-YL in synthetic surfactant lipids.

EDUKASI PERILAKU PENCEGAHAN PENYAKIT TUBERKULOSIS DI RS. WOODWARD

Tuberculosis (TB or TBC) is an infectious disease caused by the germ Mycobacterium tuberculosis. These germs usually enter the human body through breathing air into the lungs, then these germs can spread from the lungs to other parts of the body through the circulatory system, lymphatic system, through the respiratory tract (bronchus) or spread directly to other parts of the body.This community service aims to increase public knowledge and awareness in preventing the transmission of pulmonary tuberculosis. The counseling method uses leaflet media and will be carried out on December 9 2023 at the hospital. Woodward, Palu City. As a result of community service, the material presented was able to increase their knowledge as evidenced by the evaluation session, the community was asked questions and on average the community was able to answer correctly according to the material provided. Conclusion: Community service activities have been carried out. It is hoped that the excellent presence and enthusiasm of the residents can prevent the occurrence of Tuberculosis.

NOx emissions estimation methodology for air-breathing reusable access to space vehicle in conceptual design

With an expected global revenue exceeding 1 trillion USD by 2040, the space industry is one of the world's fastest-growing sectors. Given the booming investment in the space industry and the anticipated space tourism era, it is crucial to assess the impact of already operative launch assets as well as to adopt design-to-sustainability strategies for the under-development and future launchers. This paper discloses an integrated methodology to estimate nitrogen oxides emissions of a hydrogen-fuelled air-breathing concept. The proposed strategy combines multi-fidelity propulsive system modelling with 0D chemical-kinetic air/hydrogen combustion numerical simulations to define a high-fidelity emissive database representative of various on-ground and in-flight operative conditions. The propulsive and emissive databases are then used to suggest an analytical formulation able to predict nitrogen oxides emission indices in any in-flight conditions, perfectly fitting the conceptual design needs. Throughout the paper, the Skylon spaceplane and its Synergetic Air Breathing Rocket Engine are used as case study. The methodology disclosed allows proving the high competitiveness of this air-breathing space launchers with respect to famous past and current competitors, as the Space Shuttle and the Falcon 9.

Comparison of particles in exhaled air and multiple breath washout for assessment of small airway function in children with cystic fibrosis.

The introduction of modulator therapy for cystic fibrosis (CF) has led to an increased interest in the detection of small airway disease (SAD) as sensitive marker of treatment response. The particles in exhaled air (PExA) method, which records exhaled particle mass (PEx ng/L) and number (PExNR), detects SAD in adult patients. Our primary aim was to investigate if PExA outcomes in children with CF are different when compared to controls and associated with more severe disease. Secondary aims were to assess feasibility and repeatability of PExA in children with CF and to correlate PExA to multiple breath nitrogen washout (MBNW) as an established marker of SAD. Thirteen healthy children (HC), 17 children with CF with normal lung function (CF-N) (FEV1 z-score ≥ -1.64) and six with airway obstruction (CF-AO) (FEV1 z-score < -1.64) between 8 and 18 years performed MBNW followed by PExA and spirometry. Children with CF repeated the measurements after 3 months. PEx ng/L and PExNR/L per liter of exhaled breath were similar between the three groups. The lung clearance index (LCI) was significantly higher in both CF-N and CF-AO compared to HC. All participants, except one, were able to perform PExA. Coefficient of variation for PEx ng/l was (median) 0.38, range 0-1.25 and PExNR/l 0.38, 0-1.09. Correlation between LCI and PEx ng/l was low, rs 0.32 (p = .07). PExA is feasible in children. In contrast to LCI, PExA did not differentiate healthy children from children with CF suggesting it to be a less sensitive tool to detect SAD.

The Origins of the Peloponnesian War, Chapter IV, and the Development of Spartan Historical Studies

Abstract This article examines the impact on Spartan historiography of Chapter IV of de Ste. Croix’s Origins of the Peloponnesian War, focusing on his discussions of Spartan politics and society in Sections v–vi. These sections fit oddly within the overall chapter, but they blew a breath of fresh air into Spartan studies through their revisionist approach, intimations of the socio-economic bases of policy-making, and extended accounts of ‘real-life’ political episodes across the classical period. Along with Moses Finley’s near-contemporary article on Sparta, OPW significantly influenced the following generation of British historians (including the author), although they often adopted different interpretations or developed new perspectives on Spartan society only hinted at by de Ste. Croix. OPW also had an important impact on Western European historiography on Spartan politics. Its combination of constitutional and societal approaches gives it an enduring currency in the context of developing Historical Institutionalist approaches to political studies.

Breath of fresh air: Investigating the link between AGEs, sRAGE, and lung diseases.

Advanced glycation end products (AGEs) are compounds formed via non-enzymatic reactions between reducing sugars and amino acids or proteins. AGEs can accumulate in various tissues and organs and have been implicated in the development and progression of various diseases, including lung diseases. The receptor of advanced glycation end products (RAGE) is a receptor that can bind to advanced AGEs and induce several cellular processes such as inflammation and oxidative stress. Several studies have shown that both AGEs and RAGE play a role in the pathogenesis of lung diseases, such as chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, cystic fibrosis, and acute lung injury. Moreover, the soluble form of the receptor for advanced glycation end products (sRAGE) has demonstrated its ability to function as a decoy receptor, possessing beneficial characteristics such as anti-inflammatory, antioxidant, and anti-fibrotic properties. These qualities make it an encouraging focus for therapeutic intervention in managing pulmonary disorders. This review highlights the current understanding of the roles of AGEs and (s)RAGE in pulmonary diseases and their potential as biomarkers and therapeutic targets for preventing and treating these pathologies.

The comprehensive impact of thermal-PM2.5 interaction on subjective evaluation of urban outdoor space: A pilot study in a cold region of China.

Urban outdoor space has a very important impact on the quality of people's outdoor activities, which has influenced people's health and moods. Its influence is the result of the combined action of various factors. Thermal and air quality environment are important factors affecting the overall comfort of the urban outdoor space. At present, there are few research on interaction with thermal and air quality environment. Therefore, a meteorological measurement and questionnaire survey have been conducted in a representative open space in a campus in Xi'an, China. The following are the research results:(1) Mean physiological equivalent temperature (MPET) is a significant factor affecting thermal sensation vote (TSV) and thermal comfort vote (TCV). PM2.5 has no significant effect on thermal comfort vote (TCV), but it is a considerable factor affecting thermal sensation vote (TSV) when 10.2°C ≤ MPET<21°C (P = 0.023 *). (2) PM2.5 is a significant factor affecting air quality vote (AQV) and breathing comfort vote (BCV).Mean physiological equivalent temperature (MPET) has no significant impact on air quality vote (AQV), but it is a considerable factor affecting breathing comfort vote (BCV) when 10.2°C ≤ MPET<21°C (P = 0.01 **). (3) Mean physiological equivalent temperature (MPET) is a significant factor affecting overall comfort vote (OCV), but PM2.5 is not. In general, When 10.2°C ≤ MPET<21°C (-0.5 < -0.37 ≤ TCV ≤ 0.12 <0.5), the interaction between thermal and PM2.5 environment is significant on thermal sensation vote (TSV) and breathing comfort vote (BCV). This study can provide experimental support for the field of multi-factor interaction, which has shown that improving the thermal environment can better breathing comfort, while reducing PM2.5 concentration can promote thermal comfort. And can also provide reference for the study of human subjective comfort in urban outdoor space in the same latitude of the world.

Reducing Indoor Air Pollution through Personalized Ventilation for Occupants in Office Environments and Confined Spaces

With the increasing focus on indoor environmental quality, driven by the growing amount of time people spend in enclosed spaces, this study presents an approach to enhancing air distribution in office environments and confined spaces. A novel low-induction air diffuser is designed to deliver fresh, clean air in close proximity to occupants while maintaining their thermal comfort. Clean, unpolluted air is pivotal to healthy and productive workplaces. Yet, this paper underscores the importance of not sacrificing thermal comfort in the pursuit of improved indoor air quality. Inadequate thermal comfort may lead occupants to deactivate ventilation systems, negating the benefits of improved air quality. Inefficient temperature control can also result in discomfort, distractions, and reduced productivity. The innovative low-induction air diffuser resolves this issue, enhancing air quality near occupants without causing thermal discomfort. By directing air gently and efficiently, this solution is prepared to transform personalized ventilation systems, mitigating the discomfort associated with traditional jet flows while delivering high-quality breathable air. This research serves as a bridge between improved indoor air quality and thermal comfort, for office environments. It introduces a practical, energy-efficient solution that satisfies the core requirements of a healthy workspace—clean air and comfortable conditions.

A NUMERICAL MODEL FOR SCRAMJET AND RAMJET EFFICIENCY STUDY DURING DUAL AND INDIVIDUAL MODES OF OPERATION

Hypersonic airbreathing propulsion, specifically scramjet technology, represents a transformative advancement in high-speed flight. This literature review examines critical studies and technological developments that have contributed to our understanding and implementation of scramjet systems. The primary reference is the comprehensive resource provided by Utah State University, which offers detailed insights into various propulsion systems. Acknowledgements are due to Dora E. Musielak, Ph.D., for her contributions through the AIAA Training Course on Hypersonic Air Breathing Propulsion in 2018. Foundational efforts by Heiser and Pratt (1995) laid the groundwork for theoretical and practical aspects of hypersonic propulsion. Significant advancements include the development and testing of the X-43A vehicle, achieving Mach 10, and subsequent studies addressing materials, thermal protection, and aerodynamic heating challenges. Further research has optimized scramjet performance through advanced design techniques and computational simulations. This review highlights contributions from notable works on scramjet inlets, combustion systems, propulsion system airframe integration, and numerical simulations of thermodynamic nonequilibrium. The innovative design of the Rectangular-to-Elliptical Shape Transition (REST) scramjet inlet/engine is also discussed, showcasing the progress in hypersonic propulsion technology. In addition to reviewing the literature, this study presents a Python code developed for modeling scramjets or ramjets with options for normal shocks or combined shocks. The code allows users to study one of three models and analyze efficiency against inlet Mach number or turning angles. It also demonstrates the difference in performance under dual nature ramjet/scramjet operations, providing a practical tool for evaluating and comparing propulsion system efficiencies.

Multi-scale analysis of respiratory droplets transport within the breathing cloud

Infectious diseases are transmitted primarily through pathogen laden droplets commonly exhaled during respiratory events such as breathing, coughing, or sneezing. The transport and evaporation of droplets are governed by the fundamental laws of fluid mechanics and convection-diffusion. From these, analytical models can be created helping in better understanding pathogens transmission from a mechanical perspective. The droplet transport within the humid air breath cloud and the local ventilation are crucial for accurately predicting the droplet fate. Different levels of complexity are possible for modelling the breath cloud, from simple 1D models to complex unsteady 3D simulations including discrete phase models for the droplets simulation. The former are too simple to capture the fluid dynamics of intermittent jets in detail, while the latter are too computationally expensive. The current work presents a novel multi-scale approach where an analytical model of the droplet transport and evaporation is coupled to unsteady CFD simulations of warm humid puffs of exhaled air. The proposed model has the advantage of the accuracy of an analytical model and the computational cost of a relatively standard unsteady CFD simulation, and can be used to predict the trajectory of the exhaled droplets for a variety of respiratory events.