Event Abstract Back to Event The Microbial Landscape Of Breast Cancer: Examination At The Site Of Disease Caiyun Xuan1, Jaime Shamonki2, Alice Chung3, Peter Sieling1 and Delphine Lee1* 1 John Wayne Cancer Institute, Translational Immunology, United States 2 Saint John's Health Center, United States 3 Cedars-Sinai Medical Center, United States Microbes have been reported to influence various disease states including obesity, diabetes and cancer in humans. Breast cancer is the second leading cause of cancer deaths in women, with over 400,000 deaths annually worldwide. Though some risk factors such as diet, age and genetic predisposition have been identified, the majority of breast cancers have unknown etiology. Given the importance of host-microbiota interactions in human health and disease, we investigated the relationship between the breast microbiota and breast cancer. Here, we characterized and compared the bacterial species found in the breasts of healthy women and women with breast cancer. Quantitatively, we found that healthy tissue harbors more bacteria than tumor tissue (p<0.001). Qualitatively, we found that there were shifts in the microbiota associated with the diseased state, with certain bacterial genera being more abundant in healthy versus tumor tissue. Specifically, the bacterium Sphingomonas yanoikuyae is enriched in matched normal adjacent tissue compared with tumor tissue from the same patient (p<0.01). These data support the hypothesis that the presence of S. yanoikuyae may support a healthy breast environment. Our findings highlight a new area of research into the breast microbiome and its association with breast cancer development and progression. Keywords: microbiome, breast cancer risk, next generation sequencing, Microbiology Research, microbial profiling Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Xuan C, Shamonki J, Chung A, Sieling P and Lee D (2013). The Microbial Landscape Of Breast Cancer: Examination At The Site Of Disease. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00405 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Delphine Lee, John Wayne Cancer Institute, Translational Immunology, Santa Monica, United States, delphine.lee@labiomed.org Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Caiyun Xuan Jaime Shamonki Alice Chung Peter Sieling Delphine Lee Google Caiyun Xuan Jaime Shamonki Alice Chung Peter Sieling Delphine Lee Google Scholar Caiyun Xuan Jaime Shamonki Alice Chung Peter Sieling Delphine Lee PubMed Caiyun Xuan Jaime Shamonki Alice Chung Peter Sieling Delphine Lee Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.