Data management is essential to understand hematopoietic stem cell transplantation (HSCT) activity and outcomes in a country, and to design strategies to improve results. Most developing countries, however, have neither a national registry, nor data managers knowledgeable to understand the complicated medical information involved in HSCT. The best strategy to treat patients is not the same in different regions, where social conditions and education may have profound implications on transplant results. Physicians may take part in specific projects, but only trained professional data managers make registries possible and reliable. Designing registries and forms is also extremely challenging. More than 2,500 HSCT are performed in Brazil annually, most of them payed by the government. Understanding the urgent need of knowing HSCT outcomes, the Brazilian government has approved a public grant (Pronon) to train Data Managers to start a Brazilian HSCT Registry (RBTMO). Objectives: To develop a training program to capacitate new data managers in all HSCT Centers performing unrelated donor transplants. Methods: A grant developed by Ameo, a Brazilian Non-Governmental Organization, was approved by the Brazilian government. It includes to: 1) select 3 health-care professionals fluent in English, 2) train them to understand HSCT-related issues, 3) translate the CIBMTR forms to Portuguese, 4) translate and adapt the CIBMTR manual, 5) prepare teaching material; 6) contract the public centers performing unrelated donor HSCT to hire a health care professional who will be paid by the grant to be trained, and to register the patients, 7) provide a laptop with internet access; 8) online web-based training in Portuguese for 2 months withclasses and discussions 3 hours/day, 3 days/week, pre and post-evaluations and documentation of participation; 9) visit each public contracted center for at least 3 days within 3 months for personal contact, teaching and understanding local characteristics and difficulties; 10) weekly meetings to maintain and improve data managers' skills, solve questions, and to build up cooperation among data managers from the different centers, 11) 2 more cycles will follow including auditing patient registration, 12) develop a portal in Portuguese to retrieve transplant outcomes with no patient or center identifiers. Results and conclusion: Three nurses are being trained and preparing the teaching materials. The contracts will be done in 2018, and the Data Manager training will start in early 2019. By the end of 2020, we expect to have a large team of data managers trained in Brazil and a strong cooperation with the CIBMTR to use the enhanced data back to center model to have the Brazilian HSCT Registry.