Brands Of Tablets Research Articles

Quality assessment of nine brands of metformin hydrochloride tablets marketed in Abuja, Nigeria

Metformin is a drug of first choice in management of type II diabetes mellitus and the Nigerian market is flooded with many brands of metformin tablets. The aim of this study is to assess the pharmaceutical quality of nine brands of metformin tablets circulating in pharmacy outlets in Abuja. The brands were assessed for uniformity in weight, hardness, friability, disintegration time and in vitro dissolution using official methods. The content of active ingredient was also determined spectrophotometrically. All the brands had weights within the official limits, hardness was found to differ across the brands with values ranging between 1.20 and 11.50 kgF. Friability values were between 0.00 and 2.25%, disintegration time was between 2.06 and 10.36 min and within official specifications for film-coated tablets. Drug release within 60 min was between 93 and 103%, however, one of the brands fell outside the lower limit of the official specification and therefore, failed the dissolution test. Similarly, all but one of the brands were within the official specification of the percent content of active ingredient. The results highlight the need to routinely carry out market surveillance on drug products so as to safeguard the health of patients.

In Vitro Biopharmaceutical and Physicochemical Evaluation of Different Brands of Ciprofloxacin Marketed in Aden-Yemen

The current study conducted to evaluate the biopharmaceutical and physicochemical equivalence of the three available pharmaceutical dosage forms of ciprofloxacin (CIP) in the local markets (tablets, infusion and eye drops). Three brands for each dosage form were selected and coded as Tablets I, II, III; CIP infusion (Infusion I, II, III) and CIP eye drops (Eye drops I, II, III). Different in vitro quality control tests, physiochemical and determination of active ingredients contents were performed. All brands of tablets have a satisfactory result that complies with the pharmacopeia specification except the hardness of the tablets was more than the recommended value, and the salinity of Infusion II and III was lower than 0.9, the viscosity of the eye drops was lower than the specified value. Post-marketing surveillance is an essential issue to distinguish poor-quality medicines and must be routinely performed to weed out substandard and counterfeit medicine.

Pharmaceutical equivalence study of marketed ibuprofen tablets of UAE using a validated RP-HPLC method

This study was carried out on the development of the RP-HPLC method and its application in the pharmaceutical equivalence study of ibuprofen tablets that are commercially available in the United Arab Emirates pharmaceutical markets. Three local and six imported brands of ibuprofen tablets were included in this study. The physical parameters of all products were recorded. An RP-HPLC system was developed and validated for the identification and quantification of the ibuprofen present within the tablets. The dissolution study was carried out using both UV-spectrophotometry (United State Pharmacopeia 42-National Formulary-37) and the RP-HPLC method with eight sampling data points. The dissolution profiles of eight test products were compared with a reference product (Switzerland), and similarity/ difference factors were calculated. The developed RP-HPLC method was simple, precise, and suitable for the quantification of ibuprofen present within the tablets. The studied products contained 97.46%–107.58% ibuprofen. The products released about 92.44%–110.63% ibuprofen within 60 minutes except one imported product that released only 12.51% of the drug. Based on similarity factor reference ranges (50%–100%), three products exhibited more than 50% similarity in dissolution profiles. In conclusion, the studied products passed the test for physical parameters, drug contents, and dissolution study except for an imported product. Based on calculated similarity factors, three products were a pharmaceutical equivalent to the reference product in respect to dissolution profiles comparison.

IN VITRO ASSESSMENT OF PHYSICOCHEMICAL PARAMETERS OF FIVE GENERICS AMLODIPINE BESYLATE TABLETS MARKETED IN YEMEN

Objective: The present paper aims to evaluate the quality of five different brands (local and imported) of oral film-coated tablets of generic Amlodipine besylate 5 mg marketed in Sana`a-Yemen, through physiochemical parameters. Methods: Different physicochemical parameters, including the uniformity of tablet weight, hardness, thickness, disintegration time, and an assay of active ingredients, were conducted to validate the quality of generics Amlodipine Besylate 5 mg according to USP specification. Results: From the obtained results, it was observed that all the brands of Amlodipine Besylate 5 mg have passed the tests and met the specifications of USP. Results of weight variation, hardness, thickness, and disintegration time were ranged from-3.8 % to+5.13 % to-1.25 % to+3.25 %, 5.06±0.31 to 13.21±1.5, 2.682±0.04 to 3.676±0.01 and 25 s to 2 min: 30 s, respectively. The dissolution test and the assay results of all the brands are also ranged within the acceptable label claim 93.7±2.24 to 98.4±0.85 and 93.22±0.38 to 100.15±0.33, respectively. However, there is no relation was found between the disintegration time and the dissolution test. Conclusion: According to the finding, all the selected Amlodipine Besylate 5 mg brands are met pharmacopeia standards and USP specifications. Therefore, the local and imported Amlodipine Besylate 5 mg can be used safely to get the desired therapeutic efficiency.

VALIDASI METODE ANALISIS DAN PENGUJIAN FORCE DEGRADATION STUDY PADA MEREK DAGANG YANG MENGANDUNG PARACETAMOL

Paracetamol is the drug most consumed by the public,so it’s necessary to carry out strict quality assurance. Therefore, a forced degradation study was carried out using a UV-Vis spectrophotometer with various degradation conditions recommended by ICH. The research was conducted on five brands of paracetamol tablets that were treated with hydrolysis, oxidation, photolytic, and thermal treatment, which were detected by UV-Vis spectrophotometer at a wavelength of 243nm. The developed method is validated with linearity, selectivity, accuracy, precision, detection limit, and quantification parameters. The results obtained are selective, linear with a regression of 0.99; accurate with %Recovery between 99.4 - 100.9% and %CV <2%; and precision with %RSD <2%; LOD 24.35706967 mg/L; LOQ 79.95750448 mg/L. The five brands of drugs tested were subjected to hydrolysis, oxidation, photolysis, and thermal degradation. Under alkaline and oxidizing conditions, it was found that the degradation was beyond the limit of levels, according to the Indonesian Pharmacopoeia 90% - 110%.

Comparative In Vitro Quality Evaluation of Brands of Propranolol Tablet Marketed in Okada, Edo State, Nigeria.

Propranolol, a beta-blocker is used in the management of cardiovascular conditions such as irregular heart rate and high blood pressure. The study was carried out to examine the in vitro quality control tests for seven brands of propranolol hydrochloride 40 mg tablet formulation, sold in retail pharmacies in Okada, EdoState, Nigeria. The parameters determined were identification, weight variation, friability, hardness, disintegration, dissolution rate, and assay of the tablets. The tablets were evaluated for conformity with British Pharmacopoeia (BP) standards. Results obtained showed tablet weight in the range of 155.63.2 mg to 348.22.0mg, hardness ranged from 1.03 0.17to 10.70 0.90 kg/cm2, friability of < 1 % except for one brand, disintegration time of 1.37 0.15 to 18.05 2.88 min whereby two brands are uncoated tablets and assay of 90.07 1.15 to 102 1.62% with one brand deviating from the specified limit. The seven batches also released more than 80% of their drug content within 30min. Analysis of similarity factor revealed that all brands but PN-7 can be interchangeable with PN-1 in terms of dissolution profile. The study showed that propranolol samples examined passed all the Pharmacopoeial tests for satisfactory quality except PN-6 which did not comply with most of the Pharmacopoeial specifications. Thus, not all brands can be used interchangeably in clinical practice. Keywords: Propranolol; Quality Control; Dissolution; Pharmacopoeial specifications

In vitro quality evaluation of brands of promethazine tablets marketed in Edo State, Nigeria

The increasing number of multisource pharmaceuticals has necessitated the need for continuous quality assessment of products available for atients’ consumption. Promethazine is an anti-histamine used in cases of nausea, vomiting, motion sickness etc. The study was to examine the in vitro quality parameters for ten brands of promethazine hydrochloride tablets sold in retail pharmacies in Edo State, Nigeria. The parameters determined were identification, weight variation, friability, hardness, disintegration, dissolution rate and assay. All samples were evaluated for conformity with British Pharmacopoeia (BP) 2017 standards. Results obtained showed tablet weight ranging from 0.08 g ± 1.77 % to 0.255 g ± 3.557 %, hardness from 4.36 ± 0.58 to 8.33 ± 3.21 kg/cm2, friability of &lt; 1 %, disintegration time of 2.47 ± 0.90 to 69.66 ± 7.23 min and assay of 61.32 ± 2.04 to 183.19 ± 0.11%. The ten batches but one released more than 80 % of their drug content within 30 min. Analysis of similarity factor revealed other samples but PR-7 can be interchangeable with PR-1 based on dissolution profile. The results showed that not all samples examined passed all the pharmacopoeia tests for satisfactory quality. Thus, they all cannot be used interchangeably in clinical practice.&#x0D; Keywords: Promethazine; Quality Control; Dissolution; Pharmacopoeial specifications

EVALUATION OF PHARMACEUTICAL EQUIVALENCE OF VARIOUS LOCAL BRANDS OF METFORMIN HCL TABLETS IN PAKISTAN

Present study aimed to assess pharmaceutical equivalence of five different local brands of Metformin tablets in Pakistan. The brands were treated for different quality attributes according to the BP and USP pharmacopeial and non-pharmacopeial methods. Shelf life was determined by R-Gui software while model independent and dependent approaches were used for in-vitro dissolution profile study. Among all brands, A (2.83) and D (3.5) passed claimed shelf life of 3 years. Moreover, only one out of five brands that is brand A (f2= 53.58 and f1= 5.98) showed equivalence release to innovator (brand C) at each time point in BP mentioned pH 6.8 media, falling in standard range of f2=50-100 and f1=0-15 therefore they are interchangeable (P&lt;0.01). However, the other 3 brands showed insignificant similarity. Present findings supports the need to conduct post-quality evaluation by regulatory authority for locally available pharmaceutical products.

Dissolution Profile Evaluation of Eight Brands of Metformin Hydrochloride Tablets Available in Jimma, Southwest Ethiopia.

BackgroundDissolution is the critical quality control parameter and used to predict an in vivo oral bioavailability, and it is used to support bio-waiver.AimTo evaluate and compare the dissolution profile of eight brands of metformin HCL 500 mg tablets available in Jimma town, Southwest Ethiopia.MethodsThe study was conducted in Jimma town, Ethiopia. Eight (seven brands and one comparator) metformin HCL 500 mg tablets were included. The dissolution study was conducted as per United States Pharmacopeia, and the dissolution profile was compared by one-way ANOVA, model-dependent and model-independent approaches.ResultsAll of the included tablet brands complied with single-point dissolution study specification. Statistical comparisons of the dissolution profile by one-way ANOVA revealed that all brands had similar dissolution profiles (p=0.89). All of the brands had a similarity factor (f2) >50% and the difference factor (f1) <15. The entire brands followed the Weibull curve approach (the highest coefficient of determination and lowest Akaike Information Criteria) for the release of an active pharmaceutical ingredient.ConclusionAll of the brands complied with single point dissolution study and all of them could be used interchangeably with the innovator drug. All brands followed the Weibull method for the release of the drug substance.

Quality Attributes Comparison of Selected Brands of Rosuvastatin Calcium Tablets Marketed in the US and Bangladesh

Aims: This study investigated whether locally marketed rosuvastatin calcium tablets in Bangladesh have comparable physical and chemical attributes, including in vitro bioequivalence profiles, to the proprietary brand.&#x0D; Methodology: Nine generic products (G1-G9) containing 10 mg of rosuvastatin calcium were compared to the proprietary brand Crestor® (R1) and an FDA approved generic rosuvastatin calcium tablet (R2). Weight variation, diameter, thickness, friability, drug content, disintegration time and dissolution profiles were tested according to United States Pharmacopeia (USP) guidelines. In vitro bioequivalence requirements were assessed by calculating difference (f1) and similarity (f2) factors.&#x0D; Results: The generic products complied with the pharmacopeial requirements for weight variation, disintegration time and friability. All the tablets had drug ranging between 92%-105% and released more than 80% of rosuvastatin within first 15-30 minutes. However, for brands G5, G7 and G8 the f1 values were 15.7%, 15.82% and 25.21% respectively and their f2 values were 41.8, 41.6 and 32.6 respectively whereas for G9 the f2 value was 43.4. These brands have thus failed to meet in vitro bioequivalence requirements.&#x0D; Conclusion: We conclude that few substandard generics of rosuvastatin calcium has somehow found its way to the market and further studies are required to ascertain their noncompliance.

Bioequivalence study of different brands of vildagliptin in healthy human subjects

BackgroundVildagliptin is a dipeptidyl peptidase-4 inhibitor used to treat diabetes mellitus. No bioequivalence study data have been published for the Indian population comparing bioequivalence of vildagliptin brands Galvus, Zomelis, and Jalra. This study aimed to evaluate the bioequivalence between three brands of vildagliptin 50 mg tablet (test 1, Zomelis; test 2, Jalra; and reference, Galvus) and to compare these test formulations with the reference formulation to meet the regulatory requirements of bioequivalence of CDSCO, India. The study was conducted in the clinical research center of the college after enrolling 12 healthy volunteers. This study was a single-dose, randomized, open-label, balanced, three treatment, three period, under fasting condition in 12 adult healthy volunteers. After overnight fasting, the subjects received a single dose of either of any three brands of the vildagliptin tablet (T1—test 1; T2—test 2; and R—reference). The washout period was 7 days. Randomization was in the way of T1T2R in the first period, T2T1R in the second period, and RT1T2 in the third period. Blood samples were collected, after that drug concentration in the plasma was measured with the help of HPLC. Outcome measures 90% confidence interval of the geometric mean ratios (test/reference) for the LnCmax, LnAUC0-t, and LnAUC0-∞ was calculated.ResultsThe AUC0-t was 1390.03, 1401.50, and 1409.37 ng h/ml for the T1, T2, and R, respectively. Cmax was 287.89, 287.41, and 285.17 ng/ml for the T1, T2, and R, respectively. AUC0-∞ was 1452.03, 1467.59, and 1473.53 ng h/ml for the T1, T2, and R, respectively. No significant difference was observed in the pharmacokinetic parameters between the T1, T2, and R. The geometric mean ratios for T1/R for LnCmax, LnAUC0-t, and LnAUC0-∞ were 1.0014 (90% CI, 1.0002–1.0026), 0.9992 (90% CI, 0.9971–1.0013), and 0.9994 (90% CI, 0.9973–1.0016), respectively. For the T2/R, geometric mean ratios for LnCmax, LnAUC0-t, and LnAUC0-∞ were 1.0003 (90% CI, 0.9992–1.0013), 0.9988 (90% CI, 0.9969–1.0008), and 0.9985 (90% CI, 0.9961–1.0010), respectively.ConclusionIn this single-dose study involving Indian healthy volunteers under fasting conditions, the three brands of vildagliptin (Zomelis, Jalra, and Galvus) were bioequivalent as per the bioequivalence criterion of CDSCO, India.

In vitro Comparative Quality Evaluation of Formulated and Marketed Losartan Potassium 25 Mg Tablets

Background: The outcome of the drug therapy depends largely on the quality of the drug product. The lower quality of the drug product can be the reason for therapeutic failure. The present study was designed to evaluate the quality standard of Losartan Potassium tablet brands available in Bangladesh market to get an idea of quality standard of drug product people consuming in this country.&#x0D; Materials and methods: Three brands of losartan potassium were chosen randomly. Tablets of each brand were collected from individual retail outlets to gauge the qualitative evaluation and compare them by in-vitro drug release study. They were subjected to various quality control tests to measure the hardness, thickness, weight variation, friability, disintegration time, potency, stability, and dissolution profile. All these tests were performed according to the U.S. Pharmacopeia (USP) specification. Researchers further formulated a batch of tablet of Losartan Potassium and compared them with the existing brands. The formulation was prepared by optimizing the existing one available in the USP. Test results of the existing brands were taken into consideration during the optimization of the formulation.&#x0D; Results and discussion: Two brands passed the weight variation test, while one brand exceeded the range (±5%). The potency was determined instantly and 15 days after keeping the tablets in a stability chamber at 75% humidity and 60oC temperature. The potency of two brands degraded below the lower limit specified by the USP, while that of the remaining one was within the limits. Results of other tests were within the specified limits. Tablets prepared in the lab using an optimized formulation showed a better dissolution rate than the existing brands.&#x0D; Conclusion: Some of the brands failed to meet the desired quality, so the quality control system of that companies should be upgraded and a proper monitoring system should be developed by the drug administration.

Comparative in-vitro evaluation of two brands of carvedilol uncoated tablets

Comparative in-vitro evaluation of two brands of carvedilol uncoated tablets

Comparative in-vitro evaluation of two brands of carvedilol uncoated tablets

Comparative study is just a comparison study, according to formal properties, function, purpose and effectiveness. The main purpose of comparative study is, to compare a particular drug of different brands with the help of their stability, efficacy and evaluation parameters. Here we compare the carvedilol drugs different two marketed. It acts as anti-hypertensive agent so, it mainly preferred for arterial fibrillation, inhibits tachycardia, prevention of stroke, heart failure, it also works by blocking a natural substance like epinephrine, which results to cause lowers the heart rate, blood pressure and strain on the heart. In comparative studies we determined their efficacy and effectivity on the basis of various in-vitro tests like weight variation, friability, hardness, dissolution and disintegration. It can be concluded that standard quality control parameters always should be maintained not only for carvedilol or its combination but also for all kinds of medicine for getting better drug products. The parameters in this comparative study between these two brands showed somewhat variation because every brand have their own method or processing or manufacturing and formulation properties. Mainly these parameters can show the different efficacy and effectivity and made them unique from each other.

RELATIVE COMPARISON OF STABILITY AND DEGRADATION OF METHYLCOBALAMIN TABLETS OF DIFFERENT BRANDS AT DIFFERENT STORAGE SETTINGS

Objective: To assess relative comparison of stability and degradation of Methylcobalamin tablets of different brands at various storage circumstances.&#x0D; Methods: The comparative in vitro study of Methycobal (innovator brand) with its other 5 different brands Cobalamin, Neuromet, Incobal, Qbal and Mecobal was organized for evaluation of physicochemical features of hardness, thickness, friability, weight variation, disintegration time and accelerated stability at 3 temperatures, 25 °C, 30 °C±65 % and 40 °C±75 % respectively for 3 mo. Later all brands were passed through HPLC for checking the extent of degradation of drug products.&#x0D; Results: All tablet brands were within the weight variation specified limits except Mecobal with a relative standard deviation of 6.83%. The weight variation values of Methycobal, Cobalamin, Neuromet, Incobal, Qbal and Mecobal were 0.29%, 0.11%, 0.09%, 0.13%, 0.09% and 0.14% after friability test respectively as per standard limits. The average thickness of Cobalamin, Incobal and Mecobal were not within specified limits. The average hardness of all trades was within limits except Cobalamin and Mecobal exceeding 6kp. The disintegration time of all companies was as per specifications.&#x0D; Conclusion: Qbal was found economical and cost-effective. However, study facts unveiled no noteworthy variety in the Q. C assessments of Methylcobalamin brands.

Synthesis, characterization, and electropolymerization of a novel Cu(II) complex based on 1,10-phenanthroline for electrochemical determination of amoxicillin in pharmaceutical tablet formulations

UV–Vis and FT-IR results confirmed synthesis of a novel complex, aquachlorobis(1,10-phenanthroline)copper(II) iodidemonohydrate (ACP2CuIH), following a simple ion exchange reaction. CV and EIS results of potentiodynamically fabricated novel poly(ACP2CuIH)/GCE revealed modification of the electrode surface by a conductive, and electroactive polymer film leading to an increased effective electrode surface area. In contrast to the unmodified electrode, appearance of an irreversible oxidative peak at much reduced potential with five folds current enhancement at poly(ACP2CuIH)/GCE showed catalytic effect of the modifier towards oxidation of amoxicillin (AMX). DPV current response of poly(ACP2CuIH)/GCE showed linear dependence on concentration of AMX in the range 5 × 10−7 - 1.0 × 10−4 M with LOD and LOQ of 1.3 × 10−8, and 4.6 × 10−8 M, respectively. The AMX level in selected four tablet brands were in the range 95.2–101.8% of their nominal values. Spike recovery results of 98.8–100.6%, interference recovery results with less than 4.5%error, lower LOD and wider dynamic range than most of the previously reported methods validated the potential applicability of the present method based on the novel poly(ACP2CuIH)/GCE for determination of AMX in real samples with complex matrix.

Comparative Study of Different Products of Carbamazepine Tablets Available in Iraqi Market

Carbamazepine (CBZ) is a widely used antiepileptic drug to control grand mal epilepsy, as well as for the treatment of peripheral neuralgia. According to the biopharmaceutical classification system (BCS), CBZ is considered a class II drug. CBZ is characterized by a slow and irregular gastrointestinal absorption, with irregular oral bioavailability; due to its low water solubility. Therefore, the release of the drug from the dosage form (tablets in this study) and the subsequent step of dissolution represent the most important parameters that decide whether a sufficient plasma concentration will be achieved or not. In the current study, the FTIR study for the pure API, CBZ, and the different commercially available brands of CBZ conventional tablets, available in the Iraqi drug market (Mosul city as an example), were examined. Subsequently, various quality control parameters such as the weight variation, content uniformity, friability, and hardness of the conventional CBZ tablets were conducted. Moreover, the disintegration and the dissolution tests of the different brands of CBZ available in the Iraqi drug market were performed.&#x0D; Keywords: Antiepileptic Drug, Bioequivalence; Epilepsy; Generic; Brand vs generic; IVIVC; QC

A Comparative Study on In-vitro Quality Control Parameters of Different Brands of Loratadine Tablets Commercially Available in Bangladesh

Loratadine, a second generation H1-receptor antagonist, works by blocking the action of histamine and is widely prescribed for itching, runny nose, watery eyes, and sneezing from "hay fever" and other allergic conditions. To ensure quality the main requirements for a medicinal product are safety, potency, efficacy and stability. This research work aimed to compare and assess the quality levels of different local brands of loratadine tablets available in the drug market of Bangladesh. Six different brands of loratadine 10 mg tablet manufactured by the local companies were used for the analysis. The evaluation was performed through the determination of weight variation, hardness, friability, percent potency, disintegration time, and dissolution profile in accordance with USP-NF specifications. All brands showed acceptable weight variation and % friability. The percent potency for tested samples by UV method ranges from 97.02%-108%, showing none of the brands contains less than 90% of the active principle as per the specification. The result of the physical and chemical studies, such as in-vitro dissolution, disintegration, hardness, etc., has been found to differ but lie within the specified limit. After analyzing the data obtained from the tests, it can be claimed that loratadine 10 mg tablets manufactured and marketed by several local companies in Bangladesh meet the quality standard required to achieve the desired therapeutic outcomes.

Rapid and accurate verification of drug identity, purity and quality by 1H-NMR using similarity calculations and differential NMR

The illegal trade in counterfeit and fake drugs is a worldwide multi-billion dollar industry, not only generating enormous economic losses, but health problems for the general population, through direct toxicity, treatment failure and the increased generation of antibiotic resistance. Techniques for high-throughput testing of suspect medicines are needed to face the challenges of the problem. In this study we show that with nuclear magnetic resonance spectroscopy (NMR) drug compliance can be verified in a few minutes, providing data on drug identity, purity and quality without the necessity to develop a specific methodology and using a direct extraction with deuterated solvent. The evaluation of the data is facilitated by similarity calculations and differential NMR spectroscopy. The viability and limitations of this method were assessed, with the application on five different drugs, namely sertraline hydrochloride, alprazolam, vitamin D3, enalapril maleate and paracetamol, in which the individual dosage quantity of the active ingredient ranged from 750 mg down to 0.25 mg. The appropriate sample weight, solvent and internal standard were determined for each drug and quantification was carried out by choosing the most adequate NMR signals for each compound and the internal standard. With the method the accuracy of the quantification is somewhat sacrificed for increased speed in the analysis, but the measurements offer excellent precision and offer the possibility of external calibration. Spectral similarity calculations and differential NMR spectroscopy were used to compare different generic brands and detect eventual undeclared constituents and contaminants. In one brand of alprazolam tablets the undeclared constituent tristearin was found, while in paracetamol tablets the contaminant para-aminophenol was found at a level above the allowed by the legislation. The applicability and limitations of the method are discussed.

In Vitro Assay and Dissolution Study of Diclofenac Sodium Tablets Marketed In Port Harcourt, South – South Nigeria

The aim of this study is to determine the potency of Diclofenac sodium tablet available in Port Harcourt metropolis, south-south Nigeria. Diclofenac Sodium is a potent Non-Steroidal Anti-Inflammatory Drug (NSAID) commonly used as an Over the Counter (OTC) drug. Potency determination was performed to evaluate and authenticate whether the marketed samples complies with the declared specification. In vitro dissolution study was, performed to verify the potency of the drug and its relative bioavailability. Hardness was checked to verify whether it interferes with the dissolution, which might ultimately affect the drug bioavailability. In this present study, a simple, cost effective, and spectrophotometric method for the potency determination of marketed diclofenac sodium tablets is used. Six samples were randomly collected from the market and coded as A, B, C, D, E and F, and the potency determined are 80%, 98.7%, 126.9%, 99.6%, 109.2% and 91.4% respectively. Hardness and in vitro dissolution of the six brands of diclofenac sodium tablet were studied and reported. After 1 h dissolution release of samples A, B, C, D, E, and F are 135%, 30%, 70%, 122%, 38%, and 40% respectively. The results obtained from the study signified, that not all the samples analyzed complied with the BP and USP standards or requirements. Key words: Diclofenac Sodium, In vitro assay, Dissolution, Potency, Relative bioavailabiity DOI: 10.7176/JSTR/7-02-06