Abstract Data driven analysis is proven to create a competitive advantage to business. Governments and nonprofit organizations also turn to Big Data to harness its benefits and use it for social good. Among different types of data sources, location data collected from mobile networks is especially valuable for its representativeness, real-time observation, and versatility. There is a distinction between mobile positioning data (MPD) generated by the exchanges between mobile devices and the core network; versus over-the-top or system-level location data collecting individual GPS location. MPD is composed of all mobile network events regardless of the mobile phone brand, operating system, app usage, frequency bands or mobile generation; it is uniform and ubiquitous. Getting the best out of MPD relies on the knowledge of how to create an advanced algorithm for homogeneously processing this massive, complex data into insightful indicators. Anonymized and aggregated MPD enables the testing of multiple combinations with other data sources, fully abiding by GDPR, to arrive at innovative solutions. These unique insights can help tackle societal challenges (the state of mobile data for social good June 2017 GSMA, UN Global pulse). It can help to establish accurate statistics about population movements, density, location, social patterns, finances, and ambient environmental conditions. This article demonstrates how MPD has been used to help combat Covid-19 in Europe, the Middle East, and Africa. Furthermore, depending on the future direction, MPD and data analysis can serve powering economic development as well as working toward the Sustainable Development Goals, whilst respecting data privacy.