The human brain can be studied as a hierarchy of complex networks on different temporal and spatial scales. On each scale, from gene, protein, synapse, neuron and microcircuit, to area, pathway and the whole brain, many advances have been made with the development of related techniques. Brain network studies on different temporal and spatial scales are booming. However, such studies have focused on single levels, and can only reflect limited aspects of how the brain is formed and how it works. Therefore, it is increasingly urgent to integrate a variety of techniques, methods and models, and to merge fragmented findings into a uniform research framework or platform. To this end, we have proposed the concept of the brainnetome and several related programs/projects have been launched in China. In this paper, we offer a brief review on the methodologies of the brainnetome, which include techniques on different scales, the brainnetome atlas, and methods of brain network analysis. We then take Alzheimer's disease and schizophrenia as examples to show how the brainnetome can be studied in neurological and psychiatric disorders. We also review the studies of how risk genes for brain diseases affect the brain networks. Finally, we summarize the challenges for the brainnetome, and what actions and measures have been taken to address these challenges in China. It is envisioned that the brainnetome will open new avenues and some long-standing issues may be solved by combining the brainnetome with other “omes”.
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Jan 1, 2015
Wang Jiaojian + 4
Open Access
