Classification Of Brain Magnetic Resonance Images Research Articles

Enhancing brain tumor classification in MRI scans with a multi-layer customized convolutional neural network approach.

The necessity of prompt and accurate brain tumor diagnosis is unquestionable for optimizing treatment strategies and patient prognoses. Traditional reliance on Magnetic Resonance Imaging (MRI) analysis, contingent upon expert interpretation, grapples with challenges such as time-intensive processes and susceptibility to human error. This research presents a novel Convolutional Neural Network (CNN) architecture designed to enhance the accuracy and efficiency of brain tumor detection in MRI scans. The dataset used in the study comprises 7,023 brain MRI images from figshare, SARTAJ, and Br35H, categorized into glioma, meningioma, no tumor, and pituitary classes, with a CNN-based multi-task classification model employed for tumor detection, classification, and location identification. Our methodology focused on multi-task classification using a single CNN model for various brain MRI classification tasks, including tumor detection, classification based on grade and type, and tumor location identification. The proposed CNN model incorporates advanced feature extraction capabilities and deep learning optimization techniques, culminating in a groundbreaking paradigm shift in automated brain MRI analysis. With an exceptional tumor classification accuracy of 99%, our method surpasses current methodologies, demonstrating the remarkable potential of deep learning in medical applications. This study represents a significant advancement in the early detection and treatment planning of brain tumors, offering a more efficient and accurate alternative to traditional MRI analysis methods.

Brain MR Image Classification Using Superpixel-Based Deep Transfer Learning.

Nowadays, brain MR (Magnetic Resonance) images are widely used by clinicians to examine the brain's anatomy to look into various pathological conditions like cerebrovascular incidents and neuro-degenerative diseases. Generally, these diseases can be identified with the MR images as "normal" and "abnormal" brains in a two-class classification problem or as disease-specific classes in a multi-class problem. This article presents an ensemble transfer learning-inspired deep architecture that uses the simple linear iterative clustering (SLIC)-based superpixel algorithm along with convolutional neural network (CNN) to classify the MR images as normal or abnormal. Superpixel algorithm segments the input MR images into clusters of regions defined by similarity measures using perceptual feature space. These superpixel images are beneficial as they can provide a compact and meaningful role in computationally demanding applications. The superpixel images are then fed to the deep convolutional neural network (CNN) to classify the images. Three brain MR image datasets, NITR-DHH, DS-75, and DS-160, are used to conduct the experimentation. Through the use of deep transfer learning, the model achieves performance accuracy of 88.15% (NITR-DHH), 98.15% (DS-160), and 98.33% (DS-75) even with the small-scale medical image dataset. The experimentally obtained results demonstrate that the proposed method is promising and efficient for clinical applications for diagnosing different brain diseases via MR images.

Brain MRI Image Analysis and Segmentation using Machine Learning

The brain magnetic resonance imaging (MRI), analysis and segmentation plays one of the crucial roles in medical diagnosis and facilitates in an early detection of diseases in critical medical conditions, Due to the structural complexity and type of the tumor, radiologists are facing difficulties in extracting essential features of the image which are crucial in treating the patient. Therefore, correct, and meaningful segmentation of brain MRI is a challenging task and is required for further processing. This article proposes machine learning based automatic brain MRI segmentation and classification. The pre-processing step is the vital part of the algorithm, where the discrete wavelet transforms (DWT) and median filtering help in identifying and pointing the exact location of the tumor. The preprocessed image is further segmented by an improved original Fuzzy C-means (FCM) clustering technique. The feature extraction and classification is performed by support vector machine (SVM) classifier. It is found that the simulation associated with ground truth data provides better segmentation results in terms of accuracy, sensitivity, and dice coefficient.

SSCLNet: A Self-Supervised Contrastive Loss-Based Pre-Trained Network for Brain MRI Classification

Brain magnetic resonance images (MRI) convey vital information for making diagnostic decisions and are widely used to detect brain tumors. This research proposes a self-supervised pre-training method based on feature representation learning through contrastive loss applied to unlabeled data. Self-supervised learning aims to understand vital features using the raw input, which is helpful since labeled data is scarce and expensive. For the contrastive loss-based pre-training, data augmentation is applied to the dataset, and positive and negative instance pairs are fed into a deep learning model for feature learning. Subsequently, the features are passed through a neural network model to maximize similarity and contrastive learning of the instances. This pre-trained model serves as an encoder for supervised training and then the classification of MRI images. Our results show that self-supervised pre-training with contrastive loss performs better than random or ImageNet initialization. We also show that contrastive learning performs better when the diversity of images in the pre-training dataset is more. We have taken three differently sized ResNet models as the base models. Further, experiments were also conducted to study the effect of changing the augmentation types for generating positive and negative samples for self-supervised training.

Analysis of Deep Learning Techniques for Brain Tumour Classification from CT & MRI Images

Brain tumour detection in an initialpoint is a critical step to saving human life. Computed Tomography (CT) and Magnetic Resonance Image (MRI) provide very detailed information about brain tumour tissues. So the segmentation of tumour region is possible from pancreatic CT and brain MRI. CT and MRI is a non-invasive technique and it does not produce any harmful radiation to the patient. The patient suspected of tumour undergoes radiological evaluation such that the area, location and grade of the tumour can be predicted from the CT and MRI analysis. This critical information helps the doctors to decide about further treatment like chemotherapy, surgery, or radiation. The diagnosis requires an accurate and very fast segmentation and classification of CT and MRI images. But nowadays radiologists are doing this task manually and it is a tedious and time-consuming procedure. Also, there is a chance of variation in the result from one expert to another. Here comes the significance of automatic segmentation and classification of tumour types with the help of computers.The proposed work aims to develop an efficient system that can detect pancreatic and brain tumour and can classify the pancreatic CT and brain MRI into normal, benign or malignant. This work can be categorized into two approaches. Thus the dataset prepared for this research work contains CT and MRI images.The first approach proposes traditional machine learning technologies to achieve the goal. Image pre-processing, feature extraction, segmentation and classification are the various steps of the traditional machine learning method. A detailed investigation is performed through various feature extraction techniques and classification techniques for pancreatic (CT) and brain MRI. Discrete Wavelet Transform (DWT) feature, Grey Level Co-occurrence Matrix (GLCM) feature, Gabor feature, Tamura features and Edge Orientation Histogram (EOH) features and their combinations are used for the extraction of CT and MRI features. Benign tumours are non-cancerous, but malignant tumours are cancerous. In the first approach, the Support Vector Machine (SVM) is the main classifier used for pancreatic CT and brain MRI classification as normal, benign or malignant.In this technology, a huge amount of data and machines with high computational capabilities like Graphic Processing Unit (GPU) are available. Thus the second approach of this paper is to exploit all these available resources to produce accurate results. In this part, deep learning, the latest fast growing technology introduced in 2015 is used for the classification of brain MRI. A Deep Convolutional Neural Networks (DCNN) model is proposed to perform the classification task efficiently. The CNN results are compared with the results of a simple neural network classifier. This method provides accurate and it shows that deep learning based classification outperforms traditional machine learning techniques which produce an accurate result only. This research work again concentrates on the Transfer Learning (TL) methods to classify pancreatic CT and brain MRI.

An Enhanced Machine Learning Approach for Brain MRI Classification.

Magnetic Resonance Imaging (MRI) is a noninvasive technique used in medical imaging to diagnose a variety of disorders. The majority of previous systems performed well on MRI datasets with a small number of images, but their performance deteriorated when applied to large MRI datasets. Therefore, the objective is to develop a quick and trustworthy classification system that can sustain the best performance over a comprehensive MRI dataset. This paper presents a robust approach that has the ability to analyze and classify different types of brain diseases using MRI images. In this paper, global histogram equalization is utilized to remove unwanted details from the MRI images. After the picture has been enhanced, a symlet wavelet transform-based technique has been suggested that can extract the best features from the MRI images for feature extraction. On gray scale images, the suggested feature extraction approach is a compactly supported wavelet with the lowest asymmetry and the most vanishing moments for a given support width. Because the symlet wavelet can accommodate the orthogonal, biorthogonal, and reverse biorthogonal features of gray scale images, it delivers higher classification results. Following the extraction of the best feature, the linear discriminant analysis (LDA) is employed to minimize the feature space's dimensions. The model was trained and evaluated using logistic regression, and it correctly classified several types of brain illnesses based on MRI pictures. To illustrate the importance of the proposed strategy, a standard dataset from Harvard Medical School and the Open Access Series of Imaging Studies (OASIS), which encompasses 24 different brain disorders (including normal), is used. The proposed technique achieved the best classification accuracy of 96.6% when measured against current cutting-edge systems.

Effect of situational and instrumental distortions on the classification of brain MR images

Magnetic Resonance (MR) images of the brain play key role in exploiting pathological changes and non-invasive investigation of many neuro-degenerative diseases. Computer Aided Diagnosis (CAD) systems assist radiologists in interpreting MR images and classifying them into “normal” and “abnormal” categories. However, reduced strength of the used magnet in the machine or involuntary motions of the patients may lead to degraded MR images, which can negatively affect the performance of CAD system compromising the classification accuracy. This work aims at modeling these types of situations via out-of-focus blur, motion blur, effect of variation in resolution, and a combination of these on brain MR images for validating the impact of image quality on classification performance. To validate this, this article mathematically models the blurs (both individually and simultaneously) by varying the strength of image quality covariates and afterwards Deep Convolutional Neural Networks (DCNN) are employed to train and classify the distorted brain MR images. Besides, a single DCNN is experimented with a good mix of image quality and characteristics to test the reliability of the model for real-life scenario. The CNN models are validated through comprehensive evaluation on both original and degraded versions of brain MR images from two benchmark datasets DS-75 and DS-160 collected by Harvard Medical School as well as a self-collected dataset NITR-DHH. This study reveals that the models are able to classify distorted MR images and hence can be used for assisting the clinicians.

Cancerous and Non-Cancerous Brain MRI Classification Method Based on Convolutional Neural Network and Log-Polar Transformation.

Magnetic resonance imaging (MRI) offers visual representations of the interior of a body for clinical analysis and medical intervention. The MRI process is subjected to a variety of image processing and machine learning approaches to identify, diagnose, and classify brain diseases as well as detect abnormalities. In this paper, we propose an improved classification method for distinguishing cancerous and noncancerous tumors from brain MRI images by using Log Polar Transformation (LPT) and convolutional neural networks (CNN). The LPT has been applied for feature extraction of rotation and scaling of distorted images, while the integration of CNN introduces a machine learning approach for the tumor classification of distorted images. The dataset was formed with images of seven different brain diseases, and the training set was formed by applying CNN with the extracted features. The proposed method is then evaluated in comparison to state-of-the-art algorithms, showing a definite improvement of the former. The obtained results show that the machine learning approach offers better classification with a success rate of about 96% in both plain brain MR images and rotation- and scale-invariant brain MR images. This work also successfully classified T-1 and T-2 weighted images of neoplastic and degenerative brain diseases. The obtained accuracy is perfected by several kernel procedures, while the combined performance of the two wavelet transformations and a strong dataset make our method robust and efficient. Since no earlier study on machine learning approaches with rotated and scaled brain MRI has come to our attention, it is expected that our proposed method introduces a new paradigm in this research field.

An Efficient Multi-Scale Convolutional Neural Network Based Multi-Class Brain MRI Classification for SaMD.

A brain tumor is the growth of abnormal cells in certain brain tissues with a high mortality rate; therefore, it requires high precision in diagnosis, as a minor human judgment can eventually cause severe consequences. Magnetic Resonance Image (MRI) serves as a non-invasive tool to detect the presence of a tumor. However, Rician noise is inevitably instilled during the image acquisition process, which leads to poor observation and interferes with the treatment. Computer-Aided Diagnosis (CAD) systems can perform early diagnosis of the disease, potentially increasing the chances of survival, and lessening the need for an expert to analyze the MRIs. Convolutional Neural Networks (CNN) have proven to be very effective in tumor detection in brain MRIs. There have been multiple studies dedicated to brain tumor classification; however, these techniques lack the evaluation of the impact of the Rician noise on state-of-the-art deep learning techniques and the consideration of the scaling impact on the performance of the deep learning as the size and location of tumors vary from image to image with irregular shape and boundaries. Moreover, transfer learning-based pre-trained models such as AlexNet and ResNet have been used for brain tumor detection. However, these architectures have many trainable parameters and hence have a high computational cost. This study proposes a two-fold solution: (a) Multi-Scale CNN (MSCNN) architecture to develop a robust classification model for brain tumor diagnosis, and (b) minimizing the impact of Rician noise on the performance of the MSCNN. The proposed model is a multi-class classification solution that classifies MRIs into glioma, meningioma, pituitary, and non-tumor. The core objective is to develop a robust model for enhancing the performance of the existing tumor detection systems in terms of accuracy and efficiency. Furthermore, MRIs are denoised using a Fuzzy Similarity-based Non-Local Means (FSNLM) filter to improve the classification results. Different evaluation metrics are employed, such as accuracy, precision, recall, specificity, and F1-score, to evaluate and compare the performance of the proposed multi-scale CNN and other state-of-the-art techniques, such as AlexNet and ResNet. In addition, trainable and non-trainable parameters of the proposed model and the existing techniques are also compared to evaluate the computational efficiency. The experimental results show that the proposed multi-scale CNN model outperforms AlexNet and ResNet in terms of accuracy and efficiency at a lower computational cost. Based on experimental results, it is found that our proposed MCNN2 achieved accuracy and F1-score of 91.2% and 91%, respectively, which is significantly higher than the existing AlexNet and ResNet techniques. Moreover, our findings suggest that the proposed model is more effective and efficient in facilitating clinical research and practice for MRI classification.

Two-Stage Approach of Hierarchical Deep Feature Representation and Fusion Frameworks for Brain Image Analysis

In recent decades, magnetic resonance (MR) brain images have initiated a wide range of image classification and segmentation methods. Feature representation is one of the essential aspects of medical image analysis. This paper proposes and investigates specific features that address the significance of high-level tasks with little annotation for medical images. Deep learning is a futuristic area of research in biomedical image analysis, in which the scope is moving us immediately to the goal of automating tasks in intelligent retrieval systems. This approach can incorporate many levels of feature representation to construct recognition of medical cells or images. We propose a novel approach based on the deep hierarchical features of two different convolutional neural network (CNNs) model choices to achieve competitive performance in the classification task. We explore feature representation through discriminative CNN models. The principal study of our proposed work is feature representations, feature-level fusion, and classification. Meanwhile, effective fusion frameworks were employed for brain MR image classification by using serial fusion and fusion operator strategies. The accuracy of the proposed technique is demonstrated using the Cancer Imaging Archive (TCIA) and Information eXtraction from Images (IXI) datasets. To the best of our knowledge, experiment results show that CNNs feature maps as input to the classifier and are superior to the original CNNs. The performance of the support vector machines (SVM) classifier has been used to evaluate in terms of training performance and classify subjects as either normal or abnormal.

A new deep technique using R-CNN model and L1NSR feature selection for brain MRI classification

One of the most dangerous diseases in the world is brain tumors. After the brain tumor destroys healthy tissues in the brain, it multiplies abnormally, causing an increase in the internal pressure in the skull. If this condition is not diagnosed early, it can lead to death. Magnetic Resonance Imaging (MRI) is a diagnostic method frequently used in soft tissues with successful results. This study presented a new deep learning-based approach, which automatically detects brain tumors using Magnetic Resonance (MR) images. Convolutional and fully connected layers of a new Residual-CNN (R-CNN) model trained from scratch were used to extract deep features from MR images. The representation power of the deep feature set was increased with the features extracted from all convolutional layers. Among the deep features extracted, the 100 features with the highest distinctiveness were selected with a new multi-level feature selection algorithm named L1NSR. The best performance in the classification stage was obtained by using the SVM algorithm with the Gaussian kernel. The proposed approach was evaluated on two separate data sets composed of 2-class (healthy and tumor) and 4-class (glioma tumor, meningioma tumor, pituitary tumor, and healthy) datasets. Besides, the proposed approach was compared with other state-of-the-art approaches using the respective datasets. The best classification accuracies for 2-class and 4-class datasets were 98.8% and 96.6%, respectively.

Brain Magnetic Resonance Imaging Classification Using Deep Learning Architectures with Gender and Age.

Usage of effective classification techniques on Magnetic Resonance Imaging (MRI) helps in the proper diagnosis of brain tumors. Previous studies have focused on the classification of normal (nontumorous) or abnormal (tumorous) brain MRIs using methods such as Support Vector Machine (SVM) and AlexNet. In this paper, deep learning architectures are used to classify brain MRI images into normal or abnormal. Gender and age are added as higher attributes for more accurate and meaningful classification. A deep learning Convolutional Neural Network (CNN)-based technique and a Deep Neural Network (DNN) are also proposed for effective classification. Other deep learning architectures such as LeNet, AlexNet, ResNet, and traditional approaches such as SVM are also implemented to analyze and compare the results. Age and gender biases are found to be more useful and play a key role in classification, and they can be considered essential factors in brain tumor analysis. It is also worth noting that, in most circumstances, the proposed technique outperforms both existing SVM and AlexNet. The overall accuracy obtained is 88% (LeNet Inspired Model) and 80% (CNN-DNN) compared to SVM (82%) and AlexNet (64%), with best accuracy of 100%, 92%, 92%, and 81%, respectively.

Automated Brain Disease Classification using Transfer Learning based Deep Learning Models

Brain MRI (Magnetic Resonance Imaging) classification is one of the most significant areas of medical imaging. Among different types of procedures, MRI is the most trusted one to detect brain diseases. Manual and semi-automated segmentations need highly experienced radiologists and much time to detect the problem. Recently, deep learning methods have taken attention due to their automation and self-learning techniques. To get a faster result, we have used different algorithms of Convolutional Neural Network (CNN) with the help of transfer learning for classification to detect diseases. This procedure is fully automated, needs less involvement of highly experienced radiologists, and does not take much time to provide the result. We have implemented six deep learning algorithms, which are InceptionV3, ResNet152V2, MobileNetV2, Resnet50, EfficientNetB0, and DenseNet201 on two brain tumor datasets (both individually and manually combined) and one Alzheimer’s dataset. Our first brain tumor dataset (total of 7,023 images-training 5,712, testing 1,311) has 99-100 percent training accuracy and 98-99 percent testing accuracy. Our second tumor dataset (total of 3,264 images-training 2,870, testing 394) has 100 percent training accuracy and 69-81 percent testing accuracy. The combined dataset (total of 10,000 images-training 8,000, testing 2,000) has 99-100 percent training accuracy and 98-99 percent testing accuracy. Alzheimer’s dataset (total of 6,400 images-training 5,121, testing 1,279, 4 classes of images) has 99-100 percent training accuracy and 71-78 percent testing accuracy. CNN models are renowned for showing the best accuracy in a limited dataset, which we have observed in our models.

Effect of data leakage in brain MRI classification using 2D convolutional neural networks

In recent years, 2D convolutional neural networks (CNNs) have been extensively used to diagnose neurological diseases from magnetic resonance imaging (MRI) data due to their potential to discern subtle and intricate patterns. Despite the high performances reported in numerous studies, developing CNN models with good generalization abilities is still a challenging task due to possible data leakage introduced during cross-validation (CV). In this study, we quantitatively assessed the effect of a data leakage caused by 3D MRI data splitting based on a 2D slice-level using three 2D CNN models to classify patients with Alzheimer’s disease (AD) and Parkinson’s disease (PD). Our experiments showed that slice-level CV erroneously boosted the average slice level accuracy on the test set by 30% on Open Access Series of Imaging Studies (OASIS), 29% on Alzheimer’s Disease Neuroimaging Initiative (ADNI), 48% on Parkinson’s Progression Markers Initiative (PPMI) and 55% on a local de-novo PD Versilia dataset. Further tests on a randomly labeled OASIS-derived dataset produced about 96% of (erroneous) accuracy (slice-level split) and 50% accuracy (subject-level split), as expected from a randomized experiment. Overall, the extent of the effect of an erroneous slice-based CV is severe, especially for small datasets.

An enhanced CAD system based on machine Learning Algorithm for brain MRI classification

The development of Computer-Aided Design (CAD) and Computer-Aided Manufacturing (CAM) systems in the past decade has led to a remarkable advance in biomedical applications and devices. Particularly, CAM and CAD systems are employed in medical engineering, robotic surgery, clinical medicine, dentistry and other biomedical areas. Hence, the accuracy and precision of the CAD and CAM systems are extremely important for proper treatment. This work suggests a new CAD system for brain image classification by analyzing Magnetic Resonance Images (MRIs) of the brain. Firstly, we use the proposed Downsized Rank Kernel Partial Least Squares (DR-KPLS) as a feature extraction technique. Then, we perform the classification using Support Vector Machines (SVM) and we validate with a k-fold cross validation approach. Further, we utilize the Tabu search metaheuristic approach in order to determine the optimal parameter of the kernel function. The proposed algorithm is entitled DR-KPLS+SVM. The algorithm is tested on the OASIS MRI database. The proposed kernel-based classifier is found to be better performant than the existing methods.

Three‐class brain tumor classification from magnetic resonance images using separable convolution based neural network

SummaryBrain cancer is one of the deadliest hazards in the world and hence tumor classification became a dominant task in brain tumor diagnosis. There is a wide range of brain tumors, and each tumor exhibits distinct properties like location, shape, size, and texture. Thus, multi‐class brain magnetic resonance (MR) image classification became a trivial task. In this article, we have proposed a seven‐layer convolutional neural network to address three‐class brain MR image classification. We have employed separable convolution to optimize computation time. The proposed separable convolution based neural network model exhibits accuracy of 97.52% on a publicly available dataset consists of 3064 images. The proposed model has analyzed with the help of four key parameters. Our proposed model exhibits superior performance than existing methods in key parameters. Further, our model takes less training time due to sparse network consists of seven layers.

The applicability of magnetic resonance imaging classification system (MRICS) for cerebral palsy and its association with perinatal factors and related disabilities in a Croatian population-based sample

AimTo investigate the association of cerebral palsy motor disorders, perinatal factors, and related disabilities with brain magnetic resonance imaging classification score (MRICS)-based groups in a population-based sample.MethodsThe study enrolled children with cerebral palsy born from 2003 to 2015 treated at Split University Hospital who underwent brain MRI scanning. Perinatal data (plurality, birth weight, gestational age, and Apgar score) were collected from hospital records. Motor disorders of cerebral palsy (gross and fine motor function) and the related disabilities (intellectual status, speech and eating ability, epilepsy, vision and hearing status) were evaluated with neurological status assessment. Neuroimaging findings were presented as MRICS-based groups.ResultsOf 115 enrolled children, an abnormal finding on brain MRI was confirmed in 95%, including white matter injury (66%), maldevelopments (13.9%), gray matter injury (9.6%), and miscellaneous findings (6.1%). Gross and fine motor function were not significantly associated with MRICS-based group. All related disabilities and perinatal factors, except Apgar score, were significantly associated with MRICS-based group.ConclusionBrain MRICS-based groups were associated with perinatal risk factors and related disabilities of cerebral palsy, but not with common motor disorders. MRI classification score is a reliable diagnostic tool, which strongly correlates with perinatal factors and related disabilities of cerebral palsy.

Automated Diagnosis system for detection of the pathological brain using Fast version of Simplified Pulse-Coupled Neural Network and Twin Support Vector Machine

Brain abnormalities are neurological disorders of the human nervous system that contain biochemical, electrical, and structural changes in the brain and spinal cord. However, such changes produce diverse symptoms like paralysis, amnesia, and muscle weakness. The diagnosis of these abnormalities is crucial for treatment planning in the early stage to limit the progression of diseases. The brain Magnetic Resonance (MR) images are extensively used for treatment planning, but manually diagnosis of MR images is a time-consuming, expensive, and cumbersome task. Hence, in this paper, we have proposed the automated Computer-Aided Diagnosis (CAD) system for classification of brain MR images. These images are skill-stripped for removing the irrelevant tissues that improve the quality of images. We have developed the Fast version of Simplified Pulse-Coupled Neural Network (F-SPCNN) to segment the region of interest. Further, the features are extracted from the segmented images by using the Ripplet Transform (RT). Subsequently, Probabilistic Principal Component Analysis (PPCA) is employed for reducing the dimensionality of features. Finally, Twin Support Vector Machine (TWSVM) is applied for classification of brain MR images. The extensive simulation results on three standard datasets, e.g., DS-66, DS-160, and DS-255, demonstrate that the proposed method achieves better performance than the state-of-the-art methods.

A Biologically Inspired ELM-based Framework for Classification of Brain MRIs

<span style="font-size: 11.0pt; line-height: 107%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Use of medical images for clinical analysis of various critical diseases have become increasingly predominant in modern health care systems. Application of machine learning technique in this context evolves as a potential solution in terms providing faster output with high diagnostic accuracy. In this work we propose an Extreme Learning Machine (ELM) based classifier SFLA-ELM for detection of normal and pathological brain condition from brain Magnetic Resonance Images (MRIs). ELM is known for its speed and accuracy whereas the proposed method uses a swarm based evolutionary technique Shuffled Frog Leaping Algorithm (SFLA) and 10-fold cross validation method to optimally determine the network parameter of the ELM for better classification performance.</span><span style="font-size: 11.0pt; line-height: 107%; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Droid Sans Fallback'; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"> The proposed model is experimented on three different brain MRI datasets of three different brain diseases. </span><span style="font-size: 11.0pt; line-height: 107%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">To get better approximation accuracy and generalization ability for the base ELM classifier, the suitable activation function and the appropriate number of hidden layer nodes are chosen. The performance validation of the proposed framework is done under two different network conditions, i.e. fixed network structure and varying network structure, by comparing its performance with two standard hybridized ELM classifiers, namely, PSO-ELM and ABC-ELM. The comparative performance analysis suggests that the proposed SFLS-ELM gives better classification performance in diagnosing the diseases in terms of accuracy, sensitivity, specificity, F-score and Area under ROC curve (AUC).Furthermore, the SFLA-ELM also found to offer better generalization ability and better stability with more compact network structure.</span><span style="font-size: 22.0pt; mso-bidi-font-size: 16.0pt; line-height: 107%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">A Biologically Inspired ELM-based Framework for Classification of Brain MRIs</span>

Brain MR image classification for Alzheimer’s disease diagnosis using structural hippocampal asymmetrical attributes from directional 3-D log-Gabor filter responses

Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative condition whose development is characterized by lateralized brain atrophies. In AD, the hippocampus is the first brain structure to present atrophy, which, although to a lesser extent, is also a precursor to the broader asymmetrical development of the human brain. Structural magnetic resonance (MR) imaging is capable of detecting the disease-induced anatomical changes in the brain, thus aiding the diagnosis of AD. MR image attributes extracted from the hippocampal regions are commonly used for the AD classification task. However, most of the published methods do not explore hippocampal asymmetries for image classification. In this study, we propose a new technique for performing the classification of MR images for AD using only hippocampal asymmetrical attributes. By using the new proposed asymmetry index (AI), we assessed the attributes and the ones that passed the analysis of variance test, i.e., showing statistically mean differences among the classes (CN, MCI, and AD), were selected for classification. As a result of our study, the statistical analysis of our AI has shown a significant increase in hippocampal asymmetry as disease progress (CN < MCI < AD). Moreover, for the classification using clinical MR images, we obtained accuracy values of 69.44% and 82.59%; and AUC values of 0.76 and 0.9 for CN × MCI and CN × AD, respectively. Last, we found the results of our asymmetry analysis consistent with other statistical assessments and our classification results, using only asymmetry attributes comparable to (or even higher than) existing hippocampus studies.