Brain Function In Schizophrenia Research Articles

MRI and cognitive behavioral function in schizophrenia.

There is active research applying MRI to the study of brain anatomy in schizophrenia. As the technology improves and measurements are refined, this method, in combination with behavioral measures, is likely to contribute to the understanding of brain function in schizophrenia. The heterogeneity of schizophrenia challenges investigators to integrate anatomic and behavioral parameters with physiology. MRI techniques have already been applied to obtain quantitative imaging of cerebral blood flow and holds promise for combined MRI and neurobehavioral studies.

T 1 and T 2 relaxation times in schizophrenia as measured with magnetic resonance imaging

T 1 and T 2 relaxation times were measured in ten brain regions on the right and left side in a sample of 27 schizophrenic patients and 37 normal controls. The schizophrenic patients showed a prolongation of T 2 relaxation time, and to a lesser extent of T 1 relaxation time, which was more predominantly localized in the right hemisphere and in gray matter structures. These results may indicate that metabolic, physiological, or neurochemical brain function in schizophrenia is related in some way to a change in tissue fluid in neuronal cell bodies or interstitial gray matter.

Neurobehavioral Studies in Schizophrenia: Implications for Regional Brain Dysfunction

The application of neurobehavioral methods to the study of brain function in schizophrenia can provide useful information on the neurobiology of schizophrenia. Standard neuropsychological batteries were designed to assess behavioral correlates of regional brain function. Methodological considerations in the application of these tests to schizophrenia are discussed. Although there is considerable evidence for both frontal and temporal lobe dysfunction in schizophrenia, the field is likely to advance further through the systematic study of brain function. A combination of neurobehavioral and physiological data obtained simultaneously is a promising avenue to pursue, and the behavioral imaging method is presented as an example of one approach to data integration.

The Corpus Callosum and Brain Function in Schizophrenia

The Corpus Callosum and Brain Function in Schizophrenia