Bradykinin Receptor Type Research Articles

Reversal of bradykinin action: Possible involvement of prostaglandins or dual receptors

The vascular effects of synthetic bradykinin were studied in perfused isolated canine hind limb preparations. Repeated low doses of bradykinin or high doses administered at sufficiently long time intervals elicited dose-related hypotensive responses. In contrast, administration of increasing doses of bradykinin at short time intervals led first to diminishing hypotensive responses followed by frank increases in perfusion pressure. This autoreversal of bradykinin might be explainable either on the basis of known effects of bradykinin on prostaglandin synthesis with specific reference to PGF 2α, or the existence of two types of bradykinin receptors.