Recently there has been a considerable increase in the number of tall buildings, both residential and commercial, and modern trend is towards taller structures, Flat slab is most widely used systems in reinforced concrete construction in offices, residential and industrial buildings in many parts of the world. The flat plate system, in which columns directly support floor slabs without beams. To improve the performance of building having flat slabs under seismic loading, provision of flat slab with drop is proposed. The object of the present work is to compare the behaviour of multi-storey buildings having flat slabs with drops with that of conventional beam column framing so called grid slab system under linear dynamic analysis (Response spectrum analysis) with different masonry infills i.e. shear wall and concrete bracing in two different zones i.e. zone III and zone IV with medium soil type conditions. Software ETABS is used for this purpose. The parameters study are Time Period, Base shear, Displacements and Story Drift. And it is found that the structure with infills shows better performance in comparison with structures without infills. In addition to this the structure with shear wall reduced max displacement and storey drift and time period of different types of structures in both the zone in comparison with structure with concrete bracing.