To improve the accuracy of deflection prediction for prestressed concrete (PSC) box-girder bridges with a stay cable system (SCS) during tensioning, this study employs the Latin hypercube sampling (LHS) technique to sample random variables affecting long-term deflection of the main girder. A long-term deflection randomness analysis model is established, and the shear stiffness degradation factor is included to quantify the contribution of diagonal web cracking to the main girder deflection. Uncertainty and sensitivity analysis are conducted for the Dongming Huanghe River Highway Bridge. An objective function is applied to select the optimal combination of random variables, and a modified model is established and verified for accuracy. Results show that diagonal web-cracking accounts for 8.8% of total deflection and cannot be ignored, and the prestressed tension control stress, creep uncertainty coefficient, and concrete density significantly impact long-term deflection. The modified model predicts deflection with greater accuracy than the mean value model.
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