You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder II (MP77)1 Apr 2020MP77-06 GENITOURINARY TUBERCULOSIS: IS IT CLINICALLY RELEVANT TO DIFFERENTIATE MYCOBACTERIUM TUBERCULOSIS FROM MYCOBACTERIUM BOVIS? Alejandro Quiroz Compeán*, José de J. Cendejas Gomez, Adrian M. Garza Gangemi, Alfredo Ponce de Leon, Mariano J. Sotomayor de Zavaleta, Ricardo A. Castillejos Molina, and Ciudad de Mexico Alejandro Quiroz Compeán*Alejandro Quiroz Compeán* More articles by this author , José de J. Cendejas GomezJosé de J. Cendejas Gomez More articles by this author , Adrian M. Garza GangemiAdrian M. Garza Gangemi More articles by this author , Alfredo Ponce de LeonAlfredo Ponce de Leon More articles by this author , Mariano J. Sotomayor de ZavaletaMariano J. Sotomayor de Zavaleta More articles by this author , Ricardo A. Castillejos MolinaRicardo A. Castillejos Molina More articles by this author , and Ciudad de MexicoCiudad de Mexico More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000963.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Tuberculosis (TB) is the leading cause of death from a single infectious agent in the world. Mycobacterium Bovis (M. Bovis) represents 1% - 30% of the human TB disease. Genitourinary tuberculosis (GTB) caused by Mycobacterium Bovis is unknown due to unreliable diagnostic techniques that are not always able to identify subspecies within the Mycobacterium tuberculosis (M. tuberculosis) complex. The aim of this study was to identify and compare clinical differences as well as outcomes associated with M. Bovis and M. Tuberculosis genitourinary infection. METHODS: This is a retrospective observational study of prospectively collected data from 81 patients with genitourinary tuberculosis at a tertiary care center in México between 2001-2018. Every patient had a positive culture for M. Bovis or M. tuberculosis and they were divided into two groups, accordingly. We compared baseline sociodemographic, clinical characteristics and outcomes between study groups. RESULTS: Median follow-up was 20.4 months and 61.7% of GTB was caused by M. tuberculosis. The mean age of diagnosis was 43.4 (19-79) years and 54% were males. The most frequently affected organs in both groups were the kidney (96%) followed by the bladder (16%). There were no differences among socio-demographic and clinical characteristics between study groups (sex, age, rural household, socioeconomic status, alcohol consumption, and comorbidities including diabetes, human immunodeficiency virus, connective tissue diseases and solid organ transplant recipients). Disseminated TB was slightly more frequent in M. tuberculosis (58.7 vs. 41.3%, p= 0.42) and 10 patients died when compared to 2 patients of the M. Bovis (p=0.86). The most common symptom in both groups was weight loss (> 10kg in 6 months) with was slightly more prevalent in the M. tuberculosis group (56.4% vs. 43.6%, p=0.14). Fifty nine percent of the patients with M. tuberculosis had lower urinary tract symptoms when compared to 40.7% of the M. Bovis group (p=0.47). The majority of patients presented with microhematuria (78%) and 40% had sterile pyuria, with no differences between study groups. There were no differences in interventional (endourological, percutaneous or surgical) and medical management between study groups. CONCLUSIONS: In our analysis there were no differences between presentation, treatment and outcomes in GTB caused either by M. Tuberculosis or M. Bovis. To our knowledge this is the first study to assess clinical differences between these different subtypes of M. Tuberculosis complex in GTB. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1165-e1165 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alejandro Quiroz Compeán* More articles by this author José de J. Cendejas Gomez More articles by this author Adrian M. Garza Gangemi More articles by this author Alfredo Ponce de Leon More articles by this author Mariano J. Sotomayor de Zavaleta More articles by this author Ricardo A. Castillejos Molina More articles by this author Ciudad de Mexico More articles by this author Expand All Advertisement PDF downloadLoading ...