ABSTRACT The Rose Canyon fault is the southern extension of the larger Newport–Inglewood–Rose Canyon fault system, which represents a major structural boundary in the Inner Continental Borderland (ICB) offshore of southern California. Ten to fifteen percent of total plate boundary motion in southern California is thought to be accommodated by the faults of the ICB, but the exact distribution of slip is uncertain. With an onshore segment, the Rose Canyon fault offers an opportunity to measure the slip rate using traditional geodetic methods. In this study, we use Global Positioning System (GPS) surface velocities from a combined campaign and continuous GPS network to constrain elastic models of the Rose Canyon fault. We then compare the observed surface velocities with proposed conceptual models of regional fault connections that facilitate the transfer of slip into the Rose Canyon fault to assess how well the observations are explained by the models. The results of elastic half-space models suggest that the Rose Canyon fault may be slipping toward the higher end of geologic estimates, with the preferred model indicating a slip rate of 2.4 ± 0.5 mm/yr. Although limited in terms of near-fault benchmarks, we find an improved model fit using an asymmetrical elastic half-space model and a higher slip rate, suggesting a potential rheological contrast across the Rose Canyon fault, similar to observations from the northern Newport–Inglewood fault segments. Observed GPS surface velocities, background seismicity, and gravity anomalies south of San Diego Bay point toward a more easterly trace for the Rose Canyon fault, suggesting a possible connection with the San Miguel–Vallecitos fault system. Such a connection could increase the potential rupture lengths of future earthquakes and have important consequences for regional seismic hazards.