A 3D spectral boundary element method is employed to compute the dynamics of a single droplet in a microconfined shear flow. Comparisons have been made for the motion of an initially spherical droplet near a single wall and that between two parallel plates. Investigations are conducted for the influences of the capillary number, viscosity ratio, and initial location of the droplet on the droplet deformation, orientation, velocities, as well as the transition between the initial rapid deformation and the subsequent relaxation stage. Computational results for the deformation and velocities are compared with analytical predictions. It is found that the analytical predictions are limited for small deformations, large droplet-wall distances, and near equiviscous droplets.