In this paper, a methodology is presented for obtaining the plastic anisotropy of bulk metallic materials using cross-sectional indentation. This method relies on spherical indentation on the free edge of a specimen, and examining the out-of-plane residual deformation contour persisting on the cross-section after unloading. Results obtained from numerical simulation revealed that some important aspects of the out-of-plane residual deformation field are only sensitive to the extent of the material plastic anisotropy, and insensitive to strain hardening, yield strain, elastic anisotropy, and the selected displacement threshold value. An explicit equation is presented to correlate the plastic anisotropy with the characteristic parameter of the bottom shape of residual deformation contour, and it is used to uniquely determine the material plastic anisotropy in cross-sectional indentation. Effectiveness of the proposed method is verified by application on magnesium alloy AZ31B, and the plastic anisotropy parameter obtained from indentation and uniaxial tests show good agreement.