Extraordinary 3D seismic data from the Central Offshore Platform (Southern North Sea), complemented by information from 38 boreholes, reveal a 10 km-wide basement fault zone above which fluid anomalies emanate from sub-salt reservoirs to terminate in lower Cretaceous strata. Fluid blow-out pipes, chimneys and low-amplitude trails were mostly sourced from the region where NW-striking syn-rift faults intersect the N-striking basement fault zone. As a result, 73% of the mapped fluid-flow anomalies (94 out of 129) occur within the basement fault zone of interest or follow a N-S strike along its shoulders. We postulate a strong control of the basement fault zone on past fluid and heat flow, as basin models confirm that fluid and heat were mostly produced during the Cretaceous. Bottom-hole data record temperatures of ∼140 °C at present, highlighting the geothermal potential of the study area. These temperatures nevertheless contrast with the relatively constant gradient of ∼ 32 °C/km occurring both in and outside the basement fault zone. This work is important as its shows that past fluid and heat flow over a basement fault zone does not necessarily correlate with the existence of an enhanced hydrothermal system at present. However, as bottom-hole temperatures are within the benchmark values considered across Europe, it also stresses the importance of basement fault zones as key structures to find, and assess, as potential geothermal sites.