Botryoid Odontogenic Cyst Research Articles

Gingival cyst of the adult, lateral periodontal cyst, and botryoid odontogenic cyst: An updated systematic review.

The aim of the present review was to integrate the available data published on gingival cyst of the adult (GCA), lateral periodontal cyst (LPC), and botryoid odontogenic cyst (BOC) into a comprehensive analysis of their clinical/radiological features. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. A total of 146 publications (157 GCAs, 213 LPCs, 96 BOCs) were included. GCA and LPC presented highest prevalence in the sixth/fifth decades; BOC in the sixth/seventh decades. LPCs were larger lesions than GCAs and GCAs appeared at an older age than LPC. There was no statistically significant difference between them for other factors (location, symptoms, recurrence, follow-up time). In comparison with LPC, BOC lesions were larger, appeared more often in mandible and in older subjects, had more often a multilocular appearance, and presented a higher recurrence rate. Recurrence rates: GCA (3.2%), LPC (2.4%), BOC (21.7%). No factor seems to influence the recurrence rate of GCA or LPC. Multilocular radiological appearance seems to affect the recurrence rate of BOCs. Conservative surgical approaches seem to be enough for GCA/LPC. BOC presents a more aggressive behavior than GCA/LPC. Therefore, treatment of this lesion might involve some kind of adjunctive therapy after enucleation.

Botryoid odontogenic cyst. Exploration of proliferative activity, apoptosis and expression of TP53 and BCL2 compared to the histologically identical lateral periodontal and gingival cysts

The botryoid odontogenic cyst (BOC) is a rare, locally more aggressive variant of the usually indolent lateral periodontal cyst (LPC) and gingival cyst (GC). A recent case of BOC provided an opportunity for an exploratory study on the causes of its more aggressive behavior. The limited objective was to see if the BOC was sufficiently different from the other cysts to warrant an investment in a large study. Sections of neutral buffered formalin fixed, paraffin-embedded tissues from the BOC and archival specimens of four GCs, four LPCs and three odontogenic keratocysts (OKCs) were stained using immunohistochemistry for Ki-67, a marker of proliferating cells, caspase-3, a marker of cells undergoing apoptosis, tumor suppressor p53, and the apoptosis inhibitor BCL2. The mean labeling index (LI) of immunoreactive cyst epithelial cells was computed for each antibody and type of cyst. Compared to the LPCs and GCs, the BOC exhibited a moderately larger Ki-67/caspase-3 LI difference, which indicates that the BOC had a net higher rate of growth. We found a much higher level of LI, therefore likely dysregulation of p53. We also found a much higher LI of BCL2. The LIs of p53 and BCL2 in the BOC were similar to and more than twice that of the OKCs, respectively. Although meaningful statistical analysis was precluded by our use of only one case of BOC and a small number of the other cysts, the high p53 and very high BCL2 labeling indices of the BOC offer a potential explanation for its reportedly more aggressive behavior that clearly is worthy of further investigation.

Glandular odontogenic cyst: Series of five cases.

Introduction:Glandular odontogenic cyst (GOC) is a clinically rare and histopathologically unusual type of developmental odontogenic cyst with unpredictable and potentially aggressive behaviour.Materials and Methods:Archival data of cases histopathologically identified as GOC were analyzed from the Department of Oral Pathology over the past six years. The clinical, radiographic, histopathological features and treatment were evaluated. Special stains such as periodic acid Schiff, mucicarmine along with immunohistochemical staining for cytokeratin 19 were employed to confirm the histopathological diagnosis.Results:The study indicated a strong female predilection with slightly more number of cases found in maxilla than mandible. Most cases showed a well defined multilocular radiolucency. The microscopic features which aid in its differentiation from its mimickers such as central mucoepidermoid carcinoma, lateral periodontal cyst, dentigerous cyst and botryoid odontogenic cyst which were observed included presence of variable thickness of the lining epithelium, epithelial plaques and whorls, hobnail cells, ciliated cells, clear cells and goblet cells.Conclusion:The present case series aims to throw light on the clinical, radiographic and microscopic features of GOC, which may aid in its definitive diagnosis in problematic cases.

An archetypical tumor demeanor in lateral periodontal cyst

Lateral periodontal cyst is a well-documented but slightly infrequent variant of odontogenic cysts. The common site of occurrence is the mandibular canine and premolar region. These types of cyst are more commonly seen in adults and are associated with or are located lateral to the roots of vital teeth. Radiological assessment reveals unilocular, radiolucent areas. Histological findings confirm the definitive diagnosis. On histopathological examination, it can be ruled out by the presence of lining of a thin cuboidal or stratified squamous nonkeratinized epithelium and the presence of one or more epithelial thickenings or plaques. Botryoid odontogenic cyst is a variant of lateral periodontal cyst, which shows multilocular patterns radiographically and histologically. This variant, in particular, has more recurrence rate. Here, we report a case of lateral periodontal cyst having all the characteristic findings with respect to location, radiological, and histological features, with distinct clinical conduct which was managed by surgical enucleation.

Botryoid odontogenic cyst: case report with etiopathogenic, diagnostic and therapeutic considerations

The botryoid odontogenic cyst is a rare asymptomatic lesion characterized by its typical multilocular aspect similar to a bunch of grapes commonly affecting the mandible bicuspids and canine region. The possibility of this lesion representing a clinical variation of the lateral periodontal cyst is source of discussion and doubt among many authors. Our article reports a rare case of the polemic odontogenic cyst and presents considerations related to its etiopathogenic, diagnostic and therapeutic aspects.

Botryoid Odontogenic Cyst in Mandible: An Uncommon Case Report

Botryoid odontogenic cyst (BOC) is a rare multilocular variant of lateral periodontal cyst. This lesion is considered to be rare in the maxilla, its prevalence being highest between the fifth and seventh decades of life, without gender predilection. A 52-year-old female was referred for evaluation of a soft, painful swelling extending throughout almost the entire mandible, causing tooth mobility. Computed tomography showed a hypodense image involving all teeth and the basal area of the mandible. An incisional biopsy was performed, and histopathological examination revealed multiple cystic cavities with clear cells distributed throughout the cystic epithelium and focal areas of thickening. The capsule consisted of fibrous connective tissue and showed mononuclear inflammatory infiltrate. Under the diagnosis of BOC, partial mandibular resection with placement of a reconstruction plate was performed. An excisional biopsy confirmed the diagnosis of BOC. No evidence of recurrence was observed during 12 months of follow-up.

Botryoid Odontogenic Cyst: Report of Case Found in Routine Imaginological Examinations

Botryoid Odontogenic Cyst: Report of Case Found in Routine Imaginological Examinations

Diagnosis and interdisciplinary treatment of a botryoid odontogenic cyst in the posterior mandible: report of a case.

Botryoid odontogenic cysts (BOC) are considered to be rare polycystic variants of lateral periodontal cysts characterized by a multilocular growth pattern. The most frequent location of BOC is the mandible, predominantly the premolar-canine area, followed by the anterior region of the maxilla. The cyst shows a slight female predilection. This case report of a BOC demonstrates a treatment with initial fenestration and decompression of the cyst in order to prevent damage to adjacent structures such as the inferior alveolar nerve. The present case report emphasizes the importance of accurate clinical, radiographic, and histologic diagnostic procedures of unspecific radiolucent lesions in the jaws to establish a firm diagnosis and avoid inappropriate treatment strategies.

Botryoid Odontogenic Cyst in Maxillary Anterior Region With Dental Displacement: Case Report

Botryoid odontogenic cyst (BOC) is a rare developmental odontogenic cyst typically found in the mandibular canine-premolar region that exhibit a high rate of recurrence. Woman, 34, came to the college of dentistry for evaluation of a radiolucent lesion in the periapical region on tooth #11; it had developed over the preceding 2 years. Clinical examination revealed swelling in the anterior maxillary region and displacement of tooth #11, which had been treated endodontically. The patient was asymptomatic and had an unremarkable medical history. Radiographs revealed a well-defined, 8-mm unilocular radiolucency between the roots of teeth #13 and #11. Excisional biopsy was performed. Histological features included multiple cystic cavities lined by stratified squamous epithelium consisting of 3 layers that exhibited localized areas of focal thickening and clear cells. The fibrous connective tissue showed intense mononuclear inflammatory infiltrate. The final diagnosis was BOC. No signs of recurrence developed over 41 months of follow-up.

Recurrent Botryoid Odontogenic Cyst of Mandible

Recurrent Botryoid Odontogenic Cyst of Mandible

Botryoid Odontogenic Cyst: A Diagnostic Chaos

Botryoid Odontogenic cyst (BOC) originally described by Weathers and Waldron (1973) is a variant of a lateral periodontal cyst characterized by macroscopic and microscopic multilocular growth pattern. We report a case of BOC in a 21-year-old male patient. Orthopantamogram revealed a multilocular radiolucency extending from 43 to 47. The histological examination of incisional biopsy revealed a thin 2-4 layered non keratinised epithelium without rete ridges resembling a reduced enamel epithelium with few localised plaque like thickenings and occasional mural bulges. These features were suggestive of BOC. The excisional biopsy revealed histological features similar to those of incisional biopsy except for the presence of 5-6 epithelial follicles with outer columnar cells and inner stellate reticulum like cells. CD56 and calretinin immunohistochemical staining (IHC) was done. This paper highlights the unusual appearance of follicles in BOC with differential diagnosis and IHC staining characteristics.

Analysis of 153 cases of odontogenic cysts in a South Indian sample population: a retrospective study over a decade

The purpose of this study was to determine the prevalence of odontogenic cysts and to identify their clinico-pathological features among patients by studying biopsy specimens obtained from the archives of the Department of Oral and Maxillofacial Pathology, College of Dental Sciences, Davangere, Karnataka, India, during the past 10 years. Data for the study were retrieved from the case records of patients fitting the histological classification of the World Health Organization (1992). Analyzed clinical variables included age, gender, anatomical location, and histological diagnosis. Of the 2275 biopsy reports analyzed, 194 cases (8.5%) were jaw cysts, including odontogenic (6.7%) and nonodontogenic cysts (0.25%). Odontogenic cysts included 69.3% radicular, 20.3% dentigerous, 5.2% keratinizing odontogenic, 3.3% residual, and 1.9% other cysts, such as lateral periodontal, botryoid odontogenic, and gingival cysts. The most frequent clinical manifestation was swelling, followed by a combination of pain and swelling. Age, gender, and location were related to the etiopathologic characteristics of the cyst type. A definitive diagnosis can be made on the basis of clinical, radiological, and histological findings, which makes a good interdepartmental relationship between the clinicians and pathologists essential. Knowledge of the biological and histological behavior of the odontogenic cysts is required for their early detection and treatment.

Botryoid odontogenic cyst developing from lateral periodontal cyst: A rare case and review on pathogenesis

Botryoid odontogenic cyst (BOC) is considered to be a polycystic variant of the lateral periodontal cyst (LPC) as the specimen resembled a cluster of grapes. It is a non-inflammatory odontogenic cyst. The BOCs can be unicystic or multicystic. These cysts have potential to extend in the bone and become multilocular and they have a high recurrence rate. Till now, only 73 cases of BOC have been reported. The pathogenesis of BOC is still debatable. We review different pathogenesis proposed for BOC and discuss a rare case of BOC developing from lining of an abnormally large LPC which showed aggressive behaviour in terms of growth and size.

Multifocal lateral periodontal cysts: a report of 4 cases and review of the literature

Lateral periodontal cyst (LPC) is a developmental jaw cyst of odontogenic origin. It has characteristic histopathologic features that are identical to those seen in the peripherally occurring gingival cyst of adults (GCA). The polycystic variant of LPC is termed the botryoid odontogenic cyst (BOC). The histogenetic origin of LPC is probably the rests of dental lamina in the alveolar bone. In the case of BOC, it might be that several adjacent epithelial rests simultaneously undergo cystic change and eventually form a polycystic lesion. Few previous examples of multifocal occurrence of LPC can be found in the literature. We report an additional 4 patients with this rare presentation of multiple, separate LPCs, and review the literature on this topic.

Botryoid odontogenic cyst: A case report with immunohistochemical aspects

We present a case of botryoid odontogenic cyst, affecting the anterior mandible in a 59-year-old Japanese female patient. The histochemical and immunohistochemical characteristics of the lesion are described. The nature of the cyst-lining epithelium was suggestive of an odontogenic origin as revealed by the expression of CK 10/13, CK14, and CK19, all of which have been reported to be present in the human enamel organ. An insignificant PCNA-immunoreaction was observed in the cyst-lining epithelium as compared with that of the odontogenic keratocyst. Furthermore, the appearance of diastase digestible, PAS-reactive material (consistent with glycogen) was evaluated that prefunctional cells of the dental lamina are a possible origin of the lesion.

Clinical and histologic features of botryoid odontogenic cyst: a case report

IntroductionThe lateral periodontal cyst, as the name implies, occurs on a lateral periodontal location and is of developmental origin, arising from cystic degeneration of clear cells of the dental lamina. A botryoid odontogenic cyst is considered to be a rare multilocular variant of a lateral periodontal cyst.Case presentationWe report the clinical and histopathologic features of a rare case of botryoid odontogenic cyst found in an edentulous area corresponding to the right lower canine of a 64-year-old African-American woman. A multilocular radiolucency was observed, and surgical removal of the lesion revealed a nodule of rubber-like consistency measuring about 1.5 cm in diameter. Cross-sectioning of the nodule showed that it consisted of various cystic compartments. Histologically, various voluminous periodic acid-Schiff-negative clear cells randomly distributed throughout the cystic epithelium were observed, as well as cell layers showing thickenings generally formed by oval, sometimes entangled plaques. The capsule consisted of fibrous connective tissue and showed rare and discrete foci of a perivascular mononuclear inflammatory infiltrate and reactive bone-tissue fragments. The final diagnosis was botryoid odontogenic cyst.ConclusionWe provide data that allow the reader to establish the differences between botryoid odontogenic cyst, glandular odontogenic cyst, and lateral periodontal cyst, helping with the differential diagnosis. The reader will have the opportunity to review botryoid odontogenic cyst clinical and histopathologic features, including treatment.

Botryoid odontogenic cyst: A clinicopathologic study of 10 cases

Botryoid odontogenic cyst is a rare multilocular variant of lateral periodontal cysts. In this study, a series of 10 cases of botryoid odontogenic cysts retrieved from the archives of the Postgraduation Program in Oral Pathology, Federal University of Rio Grande do Norte (Brazil), were reviewed for epidemiologic data, clinical presentation, radiographic and histopathologic characteristics, treatment, and recurrence.

Surgical Treatment of Glandular Odontogenic Cysts

Glandular odontogenic cyst (GOC) is an unusual entity of jaws, which shows features that overlap with botryoid odontogenic cyst and mucoepidermoid tumor. Glandular odontogenic cyst has an uncertain histogenesis and was recently listed by the World Health Organization as a developmental odontogenic epithelial cyst: it is characterized by an epithelial lining with cuboidal or columnar cells, both at the surface and lining, with crypts or cystlike spaces within the thickness of the epithelium. The radiographic appearance of GOC varies and is not pathognomonic. Several methods of treatment of GOC including curettage, enucleation, and en bloc excision have been used. The recurrence rate of GOC described in literature varies between 21% and 55% according to the different treatment options. We report 2 patients with GOC, describe their clinicopathologic aspects, and discuss the treatment modalities in relation to 2 different clinical situations.

Case Report: Diagnosis and Treatment of a Botryoid Odontogenic Cyst Found in the Maxillary Anterior Region

IntroductionThe botryoid odontogenic cyst (BOC) is a multicompartmentalized variant of the lateral periodontal cyst (LPC) that is typically found in the premolar-canine region of the mandible. MethodsA 60-year old man was referred for evaluation of a radiolucent lesion discovered on a routine examination. Radiographs revealed a unilocular radiolucency between the roots of teeth #10 and #11. Clinically, the site appeared normal with minimal probing depths, and there were no signs of swelling, bleeding, or mobility of the adjacent teeth. The pulps of both teeth responded to cold without lingering. After patient consent, the lesion was accessed by a mucoperiosteal flap, curetted from its bony cavity, and submitted for biopsy. The site was then treated with a bone allograft and a collagen membrane. ResultsThe diagnosis of a BOC was made based on location and the histopathological findings of multiple cystic spaces lined by nonkeratinized stratified squamous epithelium. The 22-month follow-up revealed a normal clinical appearance with evidence of radiographic bone fill at the site of the lesion. ConclusionThis case shows an unusual presentation of a BOC in both location and radiographic appearance and emphasizes the importance of a microscopic examination of unilocular lesions when associated with teeth having normal responding vital pulps. The relatively high recurrence rate for the BOC warrants periodic follow-up.

Botryoid odontogenic cyst

Botryoid odontogenic cyst is an unusual type of cyst. It was first reported by Weathers and Waldron in 1973. It is simply a polycystic variant of the lateral periodontal cyst developing through cystic transformation of multiple islands of dental lamina rests. A case of botryoid odontogenic cyst in a 35-year -old female patient with its clinical, radiological and histopathological presentation is reported.