The KLOE-2 experiment is currently collecting data at DATNE the INFN e+e- collider located in the Frascati National Laboratories.The experiment has a wide physics program ranging from: discrete symmetries test, study of light unflavored mesons, searches for light mass for dark matter candidates.In this contribution the upgrade of the detector will be briefly discussed before starting a more detailed presentation on some results concerning: CPT and Lorentz Invariance tests with neutral kaons, dark forces massive boson mediator searches, hadron structure and low energy mesons interaction.