One-dimensional free fermions and hard-core bosons are often considered to be equivalent. Indeed, when restricted to nearest-neighbor hopping on a chain, the particles cannot exchange themselves, and therefore hardly experience their own statistics. Apart from the off-diagonal correlations which depend on the so-called Jordan-Wigner string, real-space observables are similar for free fermions and hard-core bosons on a chain. Interestingly, by coupling only two chains, thus forming a two-leg ladder, particle exchange becomes allowed and leads to a totally different physics between free fermions and hard-core bosons. Using a combination of analytical (strong coupling, field theory, renormalization group) and numerical (quantum Monte Carlo, density-matrix renormalization group) approaches, we study the apparently simple but nontrivial model of hard-core bosons hopping in a two-leg ladder geometry. At half filling, while a band insulator appears for fermions at large interchain hopping ${t}_{\ensuremath{\perp}}>2t$ only, a Mott gap opens up for bosons as soon as ${t}_{\ensuremath{\perp}}\ensuremath{\ne}0$ through a Kosterlitz-Thouless transition. Away from half filling, the situation is even more interesting since a gapless Luttinger liquid mode emerges in the symmetric sector with a nontrivial filling-dependent Luttinger parameter $1/2\ensuremath{\leqslant}{K}_{s}\ensuremath{\leqslant}1$. Consequences for experiments in cold atoms and spin ladders in a magnetic field, as well as disorder effects, are discussed. In particular, a quantum phase transition is expected at finite disorder strength between a one-dimensional superfluid and an insulating Bose glass phase.