We show how highest weight representations of certain infinite dimensional Lie groups can be realized on cohomology spaces of holomorphic vector bundles. This extends the classical Bott–Borel–Weil Theorem for finite– dimensional compact and complex Lie groups. Our approach is geometric in nature, in the spirit of Bott’s original generalization of the Borel–Weil Theorem. The groups for which we prove this theorem are strict direct limits of compact Lie groups, or their complexifications. We previously proved that such groups have an analytic structure. Our result applies to most of the familiar examples of direct limits of classical groups. We also introduce new examples involving iterated embeddings of the classical groups and see exactly how our results hold in those cases. One of the technical problems here is that, in general, the limit Lie algebras will have root systems but need not have root spaces, so we need to develop machinery to handle this somewhat delicate situation.